A5001137012- Orthopedic Surgery and Rehabilitation
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Shoulder Injury and Treatment
- Global Cancer Incidence and Screening
- COVID-19 and healthcare impacts
- Economic and Financial Impacts of Cancer
- Shoulder and Clavicle Injuries
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Musculoskeletal synovial abnormalities and treatments
- Immune Cell Function and Interaction
- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Elbow and Forearm Trauma Treatment
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Peripheral Nerve Disorders
- Cardiac tumors and thrombi
- Pancreatic and Hepatic Oncology Research
- Testicular diseases and treatments
- Nerve Injury and Rehabilitation
- Neuroblastoma Research and Treatments
- Hereditary Neurological Disorders
- Genetic and rare skin diseases.
Memorial Sloan Kettering Cancer Center
2024-2025
Stony Brook University
2020-2023
Hospital of the University of Pennsylvania
2018-2021
Stony Brook University Hospital
2020
Stony Brook School
2020
University of Pennsylvania
2019
Johns Hopkins University
2013-2018
University Hospitals Cleveland Medical Center
2014
Ospedale regionale di Lugano
2014
To identify the magnetic resonance (MR) imaging features that can be used to differentiate high-grade from low-grade soft-tissue sarcoma (STS).Institutional review board approval was obtained, and informed consent waived. Patients with STS who had undergone MR T1-weighted, T2-weighted, contrast material-enhanced sequences prior neoadjuvant therapy surgery were included retrospectively. Tumor grade (grades 1-3) recorded histologic specimen for each STS. Images evaluated by two observers tumor...
Abstract Bone marrow lesions on magnetic resonance (MR) imaging are common and may be seen with various pathologies. The authors outline a systematic diagnostic approach proposed categorization of etiologies bone lesions. Utilization typical features conventional MR techniques other problem-solving techniques, such as chemical shift diffusion-weighted (DWI), to achieve accurate final diagnosis has been highlighted.
Purpose To evaluate the feasibility of whole-body magnetic resonance neurography (WBMRN) in polyneuropathy for technical feasibility, distribution nerve abnormalities, and differentiation. Materials Methods Twenty WBMRN examinations were performed on a 3T scanner over 2 years. Patient demographics including history hereditary acquired neuropathy recorded. The images evaluated by two independent readers with imaging experience quality. signal size alterations measured brachial plexus,...
ABSTRACT Objectives Immunocytochemistry is often required in the cytologic assessment of malignant serous effusion, particularly for differentiating metastatic carcinoma from mesothelioma. To summarise diagnostic performance monoclonal antibody B72.3, a systematic review and meta‐analysis was conducted. Methods Five databases were searched relevant studies reviewed data extraction risk bias assessment. Pooled sensitivity, specificity, positive likelihood ratio (PLR), negative (NLR), odds...
To characterize the tumor microenvironment of testicular germ cell tumors (GCTs) using immunohistochemical markers.Seventy-seven orchiectomies, including 36 nonmetastatic (NM) seminomas, 15 metastatic (M) 13 nonseminomatous (NSGCTs), and NSGCTs, were studied with PD-1, PD-L1, FOXP3, CD68, CD163, mismatch repair (MMR) immunohistochemistry. FOXP3+ PD-1+ tumor-infiltrating lymphocytes (TILs) tumor-associated macrophages (TAMs) expressing CD68 CD163 enumerated. PDL-1 expression was evaluated on...
To retrospectively assess the qualitative and quantitative high-resolution 3-T magnetic resonance imaging (MRI) findings in nonsymptomatic baseball pitcher draft picks.Institutional review board-approved HIPAA compliant study. Three-Tesla MRI of dominant shoulder 19 asymptomatic picks detailed clinical examination was performed before contract signing. Two radiologists independently evaluation structures. Descriptive statistics were performed.Sixty-eight percent (13/19), 32% (6/19), 21%...
To investigate chemical shift imaging (CSI) with in-phase and opposed-phase (OP) gradient-echo sequences as an alternative sequence to spin-echo T1 for defining intra-medullary skeletal tumor extent.This retrospective HIPAA-compliant study was approved by our institutional review board (IRB). Twenty-three subjects histologically-proven tumors (17 appendicular, 6 axial) underwent magnetic resonance (MRI) T1-weighted spin echo (T1SE), fluid-sensitive, CSI, contrast-enhanced sequences. One...
Limited literature is available on the tumor microenvironment (TM) of upper tract urothelial carcinoma (UTUC). This study comprehensively reviews programmed death 1 receptor (PD-1)-positive and CD8+ tumor-infiltrating lymphocytes (TILs) ligand (PD-L1) expression epithelium (TE).Seventy-two nephroureterectomy specimens were analyzed for PD-L1, PD-1, CD8. One percent or more lymphohistiocyte PD-L1 was considered positive. TIL density by H&E scored semiquantitatively from 0 to 3, PD-1+ TILs...
Abstract Background Native African men (NAM) experience a disproportionate burden of prostate cancer (PCa) and have higher mortality rates compared to European American (EAM). While socioeconomic status has been implicated as driver this disparity, little is known about the genomic mechanisms distinct biological pathways that are associated with PCa native origin. Methods To understand factors contribute disparity we utilized total 406 multi‐institutional localized samples, collected by Men...
Persistent antigen exposure leads to the accumulation of lymphocytes and subsequent tertiary lymphoid structures (TLS). We investigated relationship tumor microenvironment (TME) with respect programmed death ligand 1 (PD-L1), its receptor (PD-1), TLS in upper tract urothelial carcinoma (UTUC) cases compared them UTUC associated bladder (UTUC-BCa).We retrospectively identified 72 patients UTUC. Representative slides were reviewed, counted. Immunohistochemical stains for PD-1 PD-L1 performed....
Despite continued surveillance and intravesical therapy, a significant subset of patients with lamina propria-invasive bladder cancer (T1) will progress to muscle-invasive disease or metastases.To analyze the value pathologic subcategorization T1 in predicting progression.Six substaging methods were applied retrospective cohort 73 patients, pT1 urothelial carcinoma diagnosed on biopsy/transurethral resection. Additionally, immunohistochemistry for GATA3 cytokeratin 5/6 (CK5/6) was performed...
Langerhans cell histiocytosis (LCH) is a rare disease with abnormal accumulation of the dendritic cells. In localized form (single system), self-limiting but in cases multisystem disease, one third patients develop organ dysfunction poor prognosis. The aim this study was to examine role p53 and vascular endothelial growth factor (VEGF) pathogenesis LCH look for association them extent disease.Biopsy specimens obtained from 26 definitive diagnosis were stained immunohistochemically VEGF.There...