A5088844191- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Chemotherapy-induced organ toxicity mitigation
- Bioactive Compounds and Antitumor Agents
- Crystallization and Solubility Studies
- Essential Oils and Antimicrobial Activity
- Nigella sativa pharmacological applications
- Bee Products Chemical Analysis
- Drug Transport and Resistance Mechanisms
- Respiratory viral infections research
- Inhalation and Respiratory Drug Delivery
- Ocular Surface and Contact Lens
- Gastrointestinal motility and disorders
- Protein Interaction Studies and Fluorescence Analysis
- Antibiotics Pharmacokinetics and Efficacy
- Microencapsulation and Drying Processes
- Botanical Research and Chemistry
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Peptides and Activities
- Sesquiterpenes and Asteraceae Studies
- Advanced biosensing and bioanalysis techniques
- Advancements in Transdermal Drug Delivery
- Antibiotic Resistance in Bacteria
- Biosimilars and Bioanalytical Methods
- Medicinal Plant Research
University of Monastir
2014-2024
Hôpital Sahloul
2023
Weatherford College
2023
Abstract Nanosized drug crystals have been reported with enhanced apparent solubility, bioavailability, and therapeutic efficacy compared to microcrystal materials, which are not suitable for parenteral administration. However, nanocrystal design development by bottom‐up approaches challenging, especially considering the non‐standardized process parameters in injection step. This work aims present a systematic step‐by‐step approach through Quality‐by‐Design (QbD) Design of Experiments (DoE)...
The aim of this study was to develop self- nanoemulsifying drug delivery system (SNEDDS) improve the transcorneal permeability voriconazole. A 'mixture design around a reference mixture' approach applied. This latter included four components, namely, isopropyl myristate, PEG 400, Tween® 80 and Span® as oil, co-solvent, surfactant co-surfactant, respectively. Droplet size selected response. effect mixture components on droplet analyzed by means response trace method. Optimal formulation...
This study explores a nanoemulsion (NE)-based gel incorporating Tunisian Pituranthos tortuosus essential oil, with focus on its wound-healing potential. The extracted via hydrodistillation, underwent GC-MS analysis for compositional verification. physicochemical characterization included dynamic light scattering (DLS), transmission electron microscopy (TEM), zeta potential measurement, pH, and viscosity. gelification of the NE facilitated topical application. results revealed an average...
The aim of this study is to develop a nanoemulgel encapsulating Tunisian Prickly Pear (Opuntia ficus-indica L.) seed oil (PPSO) assess, for the first time, in vivo efficacy nanoformulation on wound healing. Phytocompounds have been reported literature as having powerful pharmacological activities. However, it remains poorly exploited due low bioavailability. A nanoemulsion (NE) was designed by determining required hydrophilic–lipophilic balance (HLB) and subsequently characterized. mean...
The growing prevalence of resistance to antibiotics potentially makes Escherichia coli and Staphylococcus aureus serious pathogens, necessitating the development new antimicrobial agents. We extracted crude biosurfactants from a potential probiotic Bacillus spp. control pathogenic bacteria associated with aerobic vaginal infection. Using nanotechnology formulations, we developed nanoemulsions based on at different concentrations (1% 3.33%). results showed that these were stable, weighted...
This study develops an efficient, low-temperature process for formulating a nanoemulsion-based gel encapsulating Pituranthos tortuosus's essential oil, investigating its wound healing potential. The novel ensured stable encapsulation of the medicinal plant's oil. nanoemulsion was characterized using dynamic light scattering and transmission electron microscopy, followed by in vitro vivo tests to examine efficacy. Results revealed gel's excellent stability, high...
Our work is aimed at exploring the composition and properties of microemulsion (ME), as a drug delivery system, to enhance permeability across gastrointestinal (GI) barrier fenofibrate, BCS class II drug. It prodrug that converted rapidly after oral administration into major active metabolite which fenofibric acid. undergoes nearly complete presystemic metabolism. Its main drawback low bioavailability metabolite. A quick selection excipients was made based on capacity solubilization value...
In this study, we focused on quetiapine fumarate (QTF), a class II BCS drug. QTF is an atypical antipsychotic used in the treatment of schizophrenia and bipolar disorders. Our objective was to develop new QTF-loaded self-emulsifying drug delivery system (SEDDS) improve dissolution absorption An experimental design approach optimize SEDDS. The optimized formulation characterized for droplets size, zeta potential, PDI, stability. It then evaluated using in-vitro combined test Everted gut sac...
Abstract In the present study, a self nano-emulsifying drug delivery system (SNEDDS) was developed to evaluate efficiency of TQ in hepatic ischemia/reperfusion. SNEDDS pharmaceutically characterized droplet size, morphology, zeta potential, thermodynamic stability, and dissolution/diffusion capacity. Animals were orally pre-treated during 10 days with loaded SNEDDS. Biochemical analyses, haematoxylin-eosin staining, indirect immunofluorescence, reverse transcription polymerase chain reaction...