A5071621452- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Mast cells and histamine
- CAR-T cell therapy research
- Nanowire Synthesis and Applications
- NF-κB Signaling Pathways
- Platelet Disorders and Treatments
- Cell Adhesion Molecules Research
- Advancements in Semiconductor Devices and Circuit Design
- Reproductive Biology and Fertility
- FOXO transcription factor regulation
- Ovarian function and disorders
- Sperm and Testicular Function
- Chemical Synthesis and Analysis
- Erythrocyte Function and Pathophysiology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Reproductive Physiology in Livestock
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetes and associated disorders
- Blood disorders and treatments
- Reproductive System and Pregnancy
- Signaling Pathways in Disease
Eurofins (Germany)
2019-2021
Medical University of Vienna
2019-2020
Max Planck Institute for Molecular Biomedicine
2010-2017
University of Salzburg
2005-2010
Truncation of the cytoplasmic tail membrane-bound IgE in vivo results lower serum levels, decreased numbers IgE-secreting plasma cells and abrogation specific secondary immune responses. Here we present mouse strain KN1 that expresses a chimeric epsilon-gamma1 BCR, consisting extracellular domains epsilon gene transmembrane gamma1 gene. Thus, differences response mice reflect influence "gamma1-mediated signalling" mIgE bearing B cells. show an increased level, resulting from elevated number...
Hematopoietic progenitor kinase 1 (HPK1) is a Ste20-related serine/threonine activated by range of environmental stimuli including genotoxic stress, growth factors, inflammatory cytokines and antigen receptor triggering. Being inducibly recruited to membrane-proximal signalling scaffolds regulate NFAT, AP-1 NFkappaB-mediated gene transcription in T-cells, the function HPK1 B-cells date remains rather ill-defined.By using two loss models, we show that displays novel regulating B-cell integrin...
Abstract HAX1 was originally described as HS1‐associated protein with a suggested function in receptor‐mediated apoptotic and proliferative responses of lymphoid cells. Recent publications refer to complex multifunctional role this protein. To investigate the vivo (HS1‐associated X1) B cells, we generated Hax1‐ deficient mouse strain. Targeted deletion Hax1 resulted premature death around age 12 wk accompanied by severe reduction lymphocytes spleen, thymus bone marrow. In marrow, all B‐cell...
The hematopoietic progenitor kinase 1 (HPK1) signals into MAPK and NFκB pathways downstream of immunoreceptors, but enigmatically is a negative regulator leukocytes. Here, we report novel role for HPK1 in regulating the activation adhesion molecule leukocyte function-associated antigen-1 (LFA-1). Upon TCR stimulation, mediated by binding degranulation promoting adaptor protein (ADAP) to SLP-76, ternary complex composed ADAP/55-kDa src associated phosphoprotein (SKAP-55) RIAM translocates...
Abstract Background Recent studies revealed that maternal and embryonic contributions impact on HLA‐G protein expression might contribute to pregnancy success or failure. The main objective of this study was examine the paternal levels immunoregulatory soluble human leukocyte antigen‐G (sHLA‐G) in seminal plasma testicular biopsy samples during artificial reproductive technique (ART) treatment investigate possible correlations with other semen parameters, age, outcome female partner. Methods...
Syk and Zap-70 constitute a closely related nonreceptor protein tyrosine kinase family, of which both members are functionally indispensable for conferring their respective antigen receptors with enzymatic activity. In this study, we analyze the impact altering BCR signaling output on B-cell germinal center (GC) fate selection by constitutive, as well inducible, monoallelic loss in presence knock-in rescue allele. Cre-mediated deletion Syk(flox/Zap-70) B cells lowers pErk, but not...
ABSTRACT Rational design of chimeric antigen receptors (CARs) with optimized anti-cancer performance mandates detailed knowledge how CARs engage tumor antigens and antigen-engagement triggers activation. We analyzed CAR-mediated recognition via quantitative single molecule live-cell imaging found the sensitivity CAR-T-cells towards approximately 1000-times reduced when compared to T-cell receptor (TCR)-mediated nominal peptide/MHC complexes. While outperformed TCRs regard binding within...
Highly viscous semen reduces sperm motility significantly and can contribute to infertility. When processing samples, few techniques exist induce liquefaction in case of seminal hyperviscosity such as different washing steps mechanical treatment. The use α-chymotrypsin seems controversial due possible negative effects on fertilisation rates after vitro fertilization (IVF). main objective this study was examine the influence mild treatment samples rate artificial reproductive (ART).The 52 ART...
The nonreceptor tyrosine kinase Syk, a central regulator of immune cell differentiation and activation, is promising drug target for treatment leukemia allergic inflammatory diseases. clinical failure Syk inhibitors underscores the importance understanding regulation function activity. A series previous studies emphasized three C-terminal tyrosines in activity regulation, as docking sites downstream effector molecules, Ca2+ mobilization. Here, we investigated roles these mouse. Surprisingly,...