A5059266653- Chemical and Physical Studies
- Influenza Virus Research Studies
- Respiratory viral infections research
- Immune Response and Inflammation
- Pediatric health and respiratory diseases
- Inflammatory mediators and NSAID effects
- Enzyme function and inhibition
- Ion channel regulation and function
- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Diabetes Management and Research
- Chemical synthesis and pharmacological studies
- Metabolism, Diabetes, and Cancer
- Flavonoids in Medical Research
- Biofield Effects and Biophysics
- SARS-CoV-2 and COVID-19 Research
- Tryptophan and brain disorders
- Apelin-related biomedical research
- Pancreatic function and diabetes
- Cytokine Signaling Pathways and Interactions
- S100 Proteins and Annexins
- Quantum Electrodynamics and Casimir Effect
- Advanced Scientific Research Methods
- Biochemical Analysis and Sensing Techniques
- Circadian rhythm and melatonin
Moscow City Oncology Hospital №62
2017-2020
The therapeutic use of Abs in cancer, autoimmunity, transplantation, and other fields is among the major biopharmaceutical advances 20th century. Broader Ab-based drugs constrained because their high production costs frequent side effects. One promising approach to overcome these limitations highly diluted Abs, which are produced by gradual reduction an Ab concentration extremely low level. This technology was used create a group for treatment various diseases, depending on specificity Abs....
During the preparation of high dilutions, repeated external vibration (shaking) is used. We hypothesized that it was treatment, and not negligible content initial substance, underlies activity highly diluted preparations. In order to test this, separated from dilution process. After vibrating two tubes together on a vortex mixer (one containing water other substance) electrical conductivity radio frequency radiation intensity differed unvibrated control, ability exert modifying effect target...
The study was aimed to investigate the effect of technologically treated diclofenac (release-active dilutions (RAD diclofenac)) on anti-inflammatory activity in carrageenan-induced rat paw edema model. Ninety male Wistar albino rats (6-8 weeks) divided into nine groups (n = 10) were used. Anti-inflammatory assessed at 1, 2, 3, 4, and 6 h after subplantar injection carrageenan (0.1 ml a 1 % solution normal saline). Diclofenac alone studied 5 20 mg/kg, RAD 7.5 ml/kg their combination ml/kg,...
Purpose. To investigate the mechanism of action in peripheral tissues novel complex drug containing release-active dilutions antibodies to beta subunit insulin receptor and endothelial nitric oxide synthase (Subetta), which has shown efficacy animal models diabetes. Methods. Human mature adipocytes were incubated either with Subetta, one negative controls (placebo or vehicle), nonspecific (release-active cannabinoid type I rabbit nonimmune serum), dimethyl sulfoxide (DMSO) at 37°C a...
It has been previously shown that Subetta (a drug containing released-active forms of antibodies to the insulin receptor β-subunit and endothelial nitric oxide synthase) stimulated insulin-induced adiponectin production by mature human adipocytes in absence insulin. Therefore, it was assumed could activate receptor. To confirm this hypothesis, capacity or presence investigated. Cells were incubated either with vehicle, basal medium for 3 days. Then, treated water (100 nm) 15 min. Following...
The aim of the present study was to evaluate potential antidiabetic effects two-component drug Subetta and its components (release-active dilutions antibodies β -subunit insulin receptor (RAD Abs -InsR) endothelial nitric oxide synthase eNOS)) in Goto-Kakizaki (Paris colony) (GK/Par) diabetic rats. administered orally for 28 days once daily (5 mL/kg) compared two (2.5 mL/kg), Rosiglitazone mg/kg), vehicle mL water/kg). At day 28, fasting plasma glucose levels were significantly decreased...
The assessment of dose–response is an essential part drug development in terms the determination a drug's effective dose, finding safety endpoint, estimation pharmacokinetic profile, and even validation activity, especially for therapeutic agents with principally novel mechanism action. Drugs based on released-active forms antibodies are good example such target. In this study, efficacy antiviral Anaferon children (released-active form to interferon-gamma) was tested dose-dependent manner...
Abstract: Experimentally and clinically, it was shown that released-active form of antibodies to S100 protein (RAF Abs S100) exerts a wide range pharmacological activities: anxiolytic, antiasthenic, antiaggressive, stress-protective, antihypoxic, antiischemic, neuroprotective, nootropic. The purpose this study determine the influence RAF on major neurotransmitter systems (serotoninergic, GABAergic, dopaminergic, sigma receptors as well) which are possibly involved in its mechanism activity....
The influenza A virus accounts for serious annual viral upper respiratory tract infections. It is constantly able to modify its antigenic structure, thus evading host defence mechanisms. Moreover, currently available anti-influenza agents have a rather limited application, emphasizing the further need new effective treatments. One of them ergoferon, drug containing combined polyclonal antibodies - anti-interferon gamma, anti-CD4 receptor and anti-histamine in released-active form. purpose...
Diabetes mellitus (DM) is one of the most widespread chronic diseases in world. In DM type 2, peripheral tissues demonstrate strong resistance to endogenous insulin (insulin resistance) which caused by impaired ability hormone stimulate glucose uptake target cells (muscle, adipose or brain tissue, liver, etc.) and reduce blood level. Research data suggest that all mentioned reasons are likely be based on a disruption signal transduction from receptor (IR) into insulin-dependent intracellular...
Цель исследования - изучение возможного прямого влияния препарата «Анаферон детский» на жизненный цикл вируса гриппа А в процессе развития инфекции, а также дозозависимости противовирусного эффекта in vitro . Методика. Исследование противовирусной активности было проведено с использованием культуры клеток MDCK (Madin Darby canine kidney) и эталонных штаммов A (H1N1) pdm09: A/California/07/09 А/California/04/09, полученных от ВОЗ. Использовались методы оценки подавления Анафероном детским...