A5056726363- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Electrochemical sensors and biosensors
- Analytical Chemistry and Sensors
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Animal Genetics and Reproduction
- Pluripotent Stem Cells Research
- Neuroscience and Neuropharmacology Research
- Electrochemical Analysis and Applications
- DNA and Nucleic Acid Chemistry
- Mitochondrial Function and Pathology
- Muscle Physiology and Disorders
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- High Temperature Alloys and Creep
- Chromosomal and Genetic Variations
- Craniofacial Disorders and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Metallurgy and Material Forming
- Microfluidic and Capillary Electrophoresis Applications
- Wnt/β-catenin signaling in development and cancer
- High-Temperature Coating Behaviors
- Neurogenetic and Muscular Disorders Research
- Zebrafish Biomedical Research Applications
University of Portsmouth
2013-2025
Institut Franco-Allemand de Recherches de Saint-Louis
2019
Physikalisch-Technische Bundesanstalt
1997-2010
University of Freiburg
2003-2006
King's College London
1999-2005
Guy's Hospital
1997-2003
Forschungszentrum Jülich
1993-2002
Humboldt-Universität zu Berlin
1993-1999
King's College Hospital
1999
Centre for Higher Education
1997
ABSTRACT During development of the amniote embryo, dorsolateral territory somite is destined to give rise hypaxial skeletal musculature. To study mechanisms that lead formation this musculature, we cloned chick Lbx1 gene specific prospective myoblasts at occipital, cervical and limb levels. Using as a marker, characterised anatomical structures produce signals necessary for specification musculature by ablating them or transplanting ectopic locations in embryo. In addition, inserted BMP4...
ABSTRACT The most profound feature of the mature vertebrate somite is its organisation into dorsal dermomyotome, intermediate myotome and ventral sclerotome. We analysed role potential signalling structures in this dorsoventral pattern by ablating them or transplanting to ectopic locations chick embryos. Our data suggest that represents a naïve tissue, entirely depending on external cues for organisation. Dorsalisation signals from neural tube surface ectoderm stimulates development...
The developmental control genes containing an Antennapedia-type homeobox are clustered in insects and vertebrates. evolution of these was studied by the construction evolutionary trees statistical geometry sequence space. comparative analysis sequences reveals subdivision into three classes early metazoan evolution. This observation suggests important function even most primitive metazoans. Subsequent duplication events generated a cluster at least five last common ancestor These later...
The anterior neural ridge (ANR), and the isthmic organiser (IsO) represent two signalling centres possessing organising properties necessary for forebrain (ANR) as well midbrain rostral hindbrain development. An important mediator of ANR IsO property is molecule FGF8. Previous work has indicated that correct positioning Fgf8 expression in this domain controlled by transcription factors Otx2 Gbx2. In order to provide novel insights into roles Gbx2, we have studied mutant embryos carrying...
Abstract In order to determine whether α‐metalated (lithiated) amines are carbenoids, as α‐lithiated halides and ethers, we have determined the crystal structures of title compounds. [α‐(dimethylamino)benzyllithium–diethyl ether] 2 ([ 9 · OEt ] ) lithium bridges anionic carbon nitrogen atom which corresponds most stable calculated model structure LiCH NH . The C–N bond is only slightly (≈ 3 pm) elongated (compared neutral species). If one N ‐methyl groups in [ 7dot; replaced by a pivaloyl...
Abstract The paired box containing transcription factor Pax3 is a crucial regulator of dermomyotome and muscle development. However, the allelic series Pax3/Splotch mutants also displays characteristic vertebral column malformations, which do not result from defective dorsoventral somite pattern. Rather, sclerotomal phenotypes are reminiscent observed in segmentation/somitogenesis rachiterata pudgy . Moreover, rostrocaudal pattern somitic boundaries disturbed Splotch as monitored by...
Introduction: Increasing evidence indicates a crucial role of glutamate in the brain reward system and nicotine addiction. Because pertinent models involve frontal hippocampal glutamatergic projections, our goal was to investigate cerebral concentrations healthy subjects with different smoking behavior.
Starting from the state of art, principles for improving analytical characteristics enzyme electrodes are discussed. Coupling appropriate amperometric electrode processes with systems, e.g. urease or aminopeptidases, results in a simplification operation. Optimal sample frequencies realized on basis membranes, both small characteristic diffusion time and high activity, applied well-designed sample-processing system. Coupled reactions sequence competition type successfully used extension to...
Dacts are multi-domain adaptor proteins. They have been implicated in Wnt and Tgfβ signaling serve as a nodal point regulating many cellular activities. Dact genes so far only identified bony vertebrates. Also, the number of given species, roles protein motifs functional domains, overlap gene expression domains all not clear. To address these problems, we taken an evolutionary approach, screening for animal kingdom establishing their phylogeny synteny loci. Furthermore, performed deep...