A5016814613- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Fatty Acid Research and Health
- Neuroendocrine regulation and behavior
- Diet and metabolism studies
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Coconut Research and Applications
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Neurotoxicity Research
- Transcranial Magnetic Stimulation Studies
- Muscle metabolism and nutrition
- Neurotransmitter Receptor Influence on Behavior
- Apelin-related biomedical research
- Neonatal and fetal brain pathology
- Sodium Intake and Health
- Cardiovascular and exercise physiology
- Biofuel production and bioconversion
- Medicinal Plants and Bioactive Compounds
- Nerve injury and regeneration
- Antioxidant Activity and Oxidative Stress
- Alzheimer's disease research and treatments
Universidade Federal de Pernambuco
2010-2024
Universidade Federal da Fronteira Sul
2024
Universidade Federal de Santa Catarina
2024
ORCID
2021
Colciencias
2021
Directorate-General for Interpretation
2018
Hospital das Clínicas da Universidade Federal de Pernambuco
2014-2015
Adult, well-nourished (W) and early-malnourished (M) male Wistar rats were injected intraperitoneally for 7 days with 20 mg/kg CIT cortical spreading depression (CSD) was recorded 4 h on the day following treatment. M-animals presented lower body weights, as well higher CSD velocities of propagation, than W ones, previously reported. Compared to saline-injected controls, treated comparable weights mean velocities, per hour recording, differences being significant at second (3.29+/-0.31...
The antidepressant fluoxetine and physical exercise exert similar effects on the serotoninergic system by increasing brain serotonin availability, both show antagonistic action cortical excitability. Here we provide first assessment of interaction two together spreading depression (CSD) in young adult rats. Wistar rats (40–60 days life) received (10 mg/kg/d, orogastrically) or an equivalent volume water. Half animals from each condition were assigned to perform a treadmill, other half formed...
Ketogenic diets influence brain function and have been therapeutically used for anti-epileptic purposes. We investigated the effects of maternal ketogenic on development somatic reflex responses in rat pups. These were born from mothers receiving: (i) normal fat (7%) + protein (17%); (ii) high-fat (55.4%) protein; (iii) low (8%); (iv) (respectively, called N-17, K-17, N-8 K-8). diets, but not normal-fat delayed responses. The more evident when diet was associated with content. results...
This study explores the multifaceted influence of litter size, maternal care, exercise, and aging on rats' neurobehavioral plasticity dentate gyrus microglia dynamics. Body weight evolution revealed a progressive increase until maturity, followed by decline during aging, with larger litters exhibiting lower weights initially. Notably, exercised rats from smaller displayed higher body mature aged stages. Dentate volumes showed no significant differences among groups, except for...
Cortical spreading depression (CSD) propagation was investigated in rats under dietary essential fatty acid (EFA) deficiency over two generations (F1 and F2). Wistar rat dams received diets containing 5% fat either from coconut-oil (EFA-deficient) or soybean-oil (control). F1-pups their dams' until the day of CSD recording (30-40 days 90-100 days). F2-pups were kept on F1 diet 30-40 days. Compared to controls, EFA-deficient group had reduced (P < 0.05) body weights both F2 conditions. This...
Virgin coconut oil (CO) and treadmill exercise have been reported to improve memory performance in young rats.
Purpose: To investigate the effects of Murici extract on brain excitability-dependent phenomenon known as cortical spreading depression (CSD) and oxidative stress. Methods: Adult aged Wistar rats were supplemented with murici (150 mg/kg/day or 300 mg/kg/day) by gavage for fifteen days. Afterwards, animals submitted to a CSD electrophysiological recording stress evaluation. Results: Our results showed that aging decreased propagation velocity, catalase activity glutathione/oxidized...
AbstractAbstractL-Arginine (ARG) is the precursor of nitric oxide (NO) synthesis. NO-mediated signaling seems to be involved in phenomenon cortical spreading depression (CSD). Here, well-nourished and malnourished rats were treated, by gavage, with 150, 300 or 450 mg/kg/day L-arginine from postnatal days 7–28, CSD propagation was analyzed at 30–40 days. Compared non-treated ('naïve') water-treated controls, ARG-treated dose-dependently displayed higher CSD-velocities (P<0.05). In rats, only...
Nutritional status during development can modify the brain's electrophysiological properties and its response to drugs that reduce serotonin availability in synaptic cleft. Here we used cortical spreading depression (CSD) rat as a neurophysiological parameter investigate interaction between nutritional treatment with tianeptine, uptake enhancer. From postnatal day 2 24, well-nourished early-malnourished pups were s.c. injected tianeptine (5 or 10mg/kg; 10 ml/kg) equivalent volume of saline...
Abstract Microglia are known to regulate several aspects of the development central nervous system. When microglia colonize spinal cord, from E11.5 in mouse embryo, they interact with growing axons dorsal root ganglion sensory neurons (SNs), which suggests that may have some functions SN development. To address this issue, we analyzed effects embryonic macrophage ablation on early SNs using embryo lacking macrophages (PU.1 knock‐out mice) and immune cell ablation. We discovered that,...
We investigated the effect of early-in-life administration l-arginine, combined with physical exercise, on cortical spreading depression (CSD) in young and adult rats.
Sepsis is a clinical syndrome with high morbidity and mortality. It characterized by acute inflammatory response oxidative stress, which implicated in cerebral dysfunction. Murici (Byrsonimacrassifolia (L.) Kunth) fruit rich antioxidant compounds, could be an alternative to prevent damage tissues induced sepsis. Here, we evaluated the effects of sepsis on propagation cortical spreading depression (CSD) tested action murici extract prevention against effect Male Wistar rats (90-210 days, n =...
Objectives: This investigation studied whether physical exercise could modulate cortical spreading depression (CSD) propagation velocity in adult rat offspring from dams that had received a high-fat (HF) diet during lactation. Methods: Wistar male rats suckled by fed either control (C) or HF ad libitum. After weaning, pups standard laboratory chow. From 40 to 60 days of life, half the animals exercised on treadmill (group E); other remained sedentary S). Two additional groups (E and S)...