A5034747317- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Hearing Impairment and Communication
- Vestibular and auditory disorders
- Ear Surgery and Otitis Media
- Alzheimer's disease research and treatments
- Growth Hormone and Insulin-like Growth Factors
- Neurological disorders and treatments
- Medical Imaging Techniques and Applications
- Coronary Interventions and Diagnostics
- Parkinson's Disease Mechanisms and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Noise Effects and Management
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Inflammasome and immune disorders
- Obsessive-Compulsive Spectrum Disorders
- Circular RNAs in diseases
- Ear and Head Tumors
- Venous Thromboembolism Diagnosis and Management
- MRI in cancer diagnosis
- Neuropeptides and Animal Physiology
- Otitis Media and Relapsing Polychondritis
National Institutes for Quantum Science and Technology
2023-2025
Juntendo University
2021-2025
Okayama University
2015-2024
Matsuyama Red Cross Hospital
2024
National Cerebral and Cardiovascular Center
2019-2024
Okayama Gakuin University
2024
Juntendo University Urayasu Hospital
2021-2024
Shimane University
2023-2024
Kansai Medical University
2020-2023
Okayama University Hospital
2023
Tourette syndrome (TS) is a childhood neuropsychiatric disorder characterized by motor and vocal tics. Imaging studies found alterations in caudate (Cd) putamen volumes. To investigate possible cell populations, postmortem basal ganglia tissue from individuals with TS normal controls was analyzed using unbiased stereological techniques. A markedly higher total neuron number the globus pallidus pars interna (GPi) of TS. In contrast, lower density observed externa Cd. An increased proportion...
Abstract Corticobasal ganglia neuronal ensembles bring automatic motor skills into voluntary control and integrate them ongoing behavior. A 5% decrease in caudate (Cd) nucleus volume is the most consistent structural finding brain of patients with Tourette syndrome (TS), but cellular abnormalities that underlie this are unclear. In study density different types interneurons medium spiny neurons (MSNs) striatum was assessed postmortem brains 5 TS subjects as compared normal controls (NC) by...
Deposition of α-synuclein fibrils is implicated in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), while vivo detection pathologies these illnesses has been challenging. Here, we have developed a small-molecule ligand, C05-05, for visualizing deposits the brains living subjects. In optical positron emission tomography (PET) imaging mouse marmoset models demonstrated that C05-05 captured dynamic propagation fibrillogenesis along neural pathways, followed by disruptions...
Auditory neuropathy is a hearing disorder characterized by normal outer hair cell function and abnormal neural conduction of the auditory pathway. Aetiology clinical presentation congenital or early-onset are heterogeneous, their correlations not well understood. Genetic backgrounds associated phenotypes were investigated systematically screening cohort 23 patients from unrelated Japanese families. Of patients, 13 (56.5%) had biallelic mutations in OTOF, whereas little no association was...
Abstract Progressive Supranuclear Palsy (PSP) is a neurodegenerative disorder characterized by movement impairments and frontal cognitive dysfunctions. While motor symptoms are linked with subcortical tau deposits, mechanisms underlying the remain unclear due to limited accumulation in cortex heterogeneous distribution. Here, we combined high-contrast PET normative connectome identify common network extended from deposits PSP. Regions deposition were connected cortical that was not...
MicroRNAs (miRNAs) regulate biological processes by inhibiting translation and causing mRNA degradation. In this study, we identified the miRNAs involved in development progression of lupus nephritis (LNs) verified their roles. Total RNA, extracted from PBMCs collected patients with LNs before after treatment, was used for miRNA array analysis to identify whose expression significantly altered. The results were confirmed using qRT-PCR. transfected into normal human mesangial cells (NHMCs),...
18F-SPAL-T-06 and 18F-C05-05 are two novel positron emission tomography (PET) radioligands targeting α-synuclein fibrils. Our study aimed to evaluate the biodistribution, safety, radiation dosimetry of each tracer in humans. Biodistribution studies were carried out with healthy volunteers for tracer, (one female one male volunteer, both aged 63 years) 73 years, respectively). After injection either dynamic PET images acquired from head upper thigh. Effective dose was estimated using...
The OTOF gene (Locus: DFNB9), encoding otoferlin, is reported to be one of the major causes non-syndromic recessive sensorineural hearing loss, and also most common cause auditory neuropathy spectrum disorder (ANSD). In present study, we performed mutation analysis using massively parallel DNA sequencing (MPS). purpose this study was reveal frequency precise genetic clinical background OTOF-related loss in a large population. A total 2,265 Japanese (SNHL) patients compatible with autosomal...
STRONG positive signals for PrRP mRNA and PrRP-like immunoreactivity (PrRP-LI) were detected in the nucleus of solitary tract ventral lateral reticular formation caudal medulla oblongata. Weak seen scattered from hypothalamic dorsomedial (DMH) to ventromedial (VMH). Nerve processes terminals with PrRP-LI septal region diencephalon. These nerve also clearly visible around capillary walls vicinity ependymal cells third ventricles. observations suggested that might be secreted into systemic...
Central diabetes insipidus (CDI), which is characterized by polyuria and polydipsia, caused a deficiency of the antidiuretic hormone arginine vasopressin (AVP). While CDI treated with desmopressin, an analogue AVP, intranasal formulation inconvenient patients reportedly prefer oral to one. In Japan, desmopressin had been only for treatment until 2012, when orally disintegrating tablet (ODT) was approved treatment. this study we analyzed 26 in whom switched ODT. The mean daily dose 10 ± 8...
Abstract More than 400 syndromes associated with hearing loss and other symptoms have been described, corresponding to 30% of cases hereditary loss. In this study we aimed clarify the mutation spectrum syndromic patients in Japan by using next-generation sequencing analysis a multiple targeted resequencing panel (36 target genes). We analyzed single nucleotide variants, small insertions, deletions copy number variations genes. enrolled 140 any 14 (BOR syndrome, Waardenburg osteogenesis...
We assess the clinical characteristics of patients with cryopyrin-associated periodic syndrome (CAPS) in Japan and evaluate real-world efficacy safety interleukin-1 (IL-1) inhibitors, primarily canakinumab.
Objective Although astrocytic pathology is a pathological hallmark of progressive supranuclear palsy (PSP), its pathophysiological role remains unclear. This study aimed to assess astrocyte reactivity in vivo patients with PSP. Furthermore, we investigated alterations brain lactate levels and their relationship reactivity. Methods We included 30 PSP‐Richardson syndrome healthy controls; patients, tau deposition was confirmed through 18 F‐florzolotau positron emission tomography....
The present study examined a novel function of PRL-releasing peptide (PrRP) on the neuroendocrine. PrRP-immunoreactive nerve fibers and terminals were located in vicinity somatostatin (SOM)-neurons hypothalamic periventricular nucleus (PerVN). Immuno-electron microscopy revealed that made synaptic contacts with nonimmunoreactive neuronal elements PerVN. Intracerebroventricular (icv) administration PrRP induced immediate early gene, NGFI-A, SOM-neurons Double-labeling situ hybridization...
To clarify how the pure-tone threshold (PTT) on PTA predicts speech perception (SP) in elderly Japanese persons.Data PTT and SP were cross-sectionally analyzed persons (656 ears 353 patients, aged ≥65 years). Correlations of average all tested frequencies evaluated by Pearson's correlation coefficient simple linear regression. After adjusting for sex, laterality ears, age, relationship frequency-specific with impaired ≤50% was estimated logistic regression models.SP correlated well (r =...
Conclusions: The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays an important role in the pathogenesis of middle ear diseases. Modulation inflammasome-mediated inflammation may be a novel therapeutic strategy for cholesteatoma and chronic otitis media. Objective: NLRP3 is critical molecule mediating interleukin (IL)-1β responses. However, expression media has not been fully examined. This study sought to assess NLRP3, ASC (apoptosis-associated...