A5011032790- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Viral-associated cancers and disorders
- Ocular Diseases and Behçet’s Syndrome
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Gastrointestinal motility and disorders
- Cell Adhesion Molecules Research
- Toxin Mechanisms and Immunotoxins
- Peptidase Inhibition and Analysis
- Medicinal Plant Pharmacodynamics Research
- Atherosclerosis and Cardiovascular Diseases
- Synthesis and Biological Evaluation
- Protein purification and stability
- Helicobacter pylori-related gastroenterology studies
- Cytomegalovirus and herpesvirus research
- Gut microbiota and health
- Viral Infectious Diseases and Gene Expression in Insects
- vaccines and immunoinformatics approaches
- Protease and Inhibitor Mechanisms
- NF-κB Signaling Pathways
- Nuclear Receptors and Signaling
- Biochemical and Structural Characterization
- Galectins and Cancer Biology
- CRISPR and Genetic Engineering
GOUZ YaO "Solovyov NV Clinical Emergency Hospital"
2025
A N Bach Institute of Biochemistry
2017-2023
Intersectoral Research and Technology Complex Eye Microsurgery
2022
University of Aberdeen
2014
Pfizer (United Kingdom)
2012
Kiel University
2003-2006
Human ciliary neurotrophic factor (CNTF) is a cytokine that exerts neuroprotective effect in multiple sclerosis and amyotrophic lateral sclerosis. Clinical application of human CNTF, however, was prevented by high toxicity at higher dosages. CNTF elicits cellular responses induction receptor complex consisting the α-receptor (CNTFR), which not involved signal transduction, β-receptors gp130 leukemia inhibitory (LIFR). Previous studies with rat demonstrated unable to interact interleukin-6...
Nonimmune fetal dropsy is considered as a severe heterogeneous pathology, which accounts for about 80% of all identified water droplets. A review the scientific literature presented. The clinical case confirmation parvovirus infection in development NIVP. article reflects experience doctors diagnosis and treatment this rare disease.
Induced costimulatory ligand (ICOSL) plays an important role in the activation of T cells through its interaction with inducible costimulator, ICOS. Suppression full cell can be achieved by blocking this and has been shown to effective means ameliorating disease models autoimmunity inflammation. In study, we demonstrated ability a novel class anti-ICOSL antigen-binding single domains derived from sharks (VNARs) effectively reduce inflammation murine model non-infectious uveitis. initial...
Single-domain Variable New Antigen Receptors (VNARs) from the immune system of sharks are smallest naturally occurring binding domains found in nature. Possessing flexible paratopes that can recognize protein motifs inaccessible to classical antibodies, VNARs have yet be exploited for development SARS-CoV-2 therapeutics. Here, we detail identification a series VNAR phage display library screened against receptor domain (RBD). The ability neutralize pseudotype and authentic live virus...
Molecular engineering to increase the percentage identity common human immunoglobulin sequences of non-human therapeutic antibodies and scaffolds has become standard practice. This strategy is often used reduce undesirable immunogenic responses, accelerating clinical development candidate domains. The first humanized shark variable domain (VNAR) was reported by Kovalenko colleagues anti-human serum albumin (HSA), clone E06, as a model construct number versions including huE06v1.10. study...
The management of chronic inflammatory diseases such as bowel disease (IBD), psoriasis, and rheumatoid arthritis (RA) has significantly improved over the last decade with clinical availability anti-TNF-α biologics. Despite this undoubted treatment success, a combination acquired resistance together an increased risk systemic complications, means that significant number patients either fail to find suitable targeted therapy or frustratingly discover approach did work is no longer efficacious....
ABSTRACT Human herpesvirus 8 (HHV-8) encodes several putative oncogenes, which are homologues to cellular host genes known function in cell cycle regulation, control of apoptosis, and cytokine signaling. Viral interleukin (vIL-6) is believed play an important role the pathogenesis Kaposi's sarcoma as well primary effusion lymphoma multicentric Castleman's disease. Therefore, vIL-6 a promising target for novel therapies directed against HHV-8-associated diseases. By phage display screening...
Pathologies arising as a consequence of human herpesvirus-8 (HHV8) infections are closely associated with the autocrine activity HHV8 encoded IL-6 (vIL-6), which promotes proliferation infected cells and their resistance to apoptosis. In this present report, studies show that vIL-6 may also be important in influencing host's immunological response secondary infections. Using peritoneal inflammation model acute bacterial infection, was found specifically block neutrophil recruitment vivo...
Treatment of functional digestive disorders is not always effective. Therefore, a search for new application points potential drugs perspective. Our aim to evaluate the effect rebamipide on symptom severity, intestinal barrier status, and microbiota composition function in patients with diarrheal variant irritable bowel syndrome overlapping dyspepsia (D-IBSoFD). Sixty were randomized receive trimebutine (TRI group), + (T R or (REB group) 2 months. At beginning end study, assessed general...
Lymphocyte costimulation plays a central role in immunology, inflammation, and immunotherapy. The inducible T cell costimulator (ICOS) is expressed on cells following peptide: MHC engagement with CD28 costimulation. interaction of ICOS its sole ligand, the costimulatory ligand (ICOSL; also known as B7-related protein-1), triggers number key activities including differentiation cytokine production. Suppression activation can be achieved by blocking this has been shown to an effective means...
Purpose: We assess the efficacy of two next-generation biologic therapies in treating experimental autoimmune uveitis. Methods: Variable binding domains from shark immunoglobulin novel antigen receptors (VNARs) were fused with a mouse IgG2a constant domain (Fc) to generate VNAR-Fc molecules specificity tumor necrosis factor alpha (TNFα) or inducible T-cell costimulatory ligand (ICOSL). Treatment fusion proteins was compared treatment dexamethasone vehicle Lewis rat model uveitis (EAU)....
Aberrant activity of the cysteine protease Cathepsin S (CTSS) has been implicated across a wide range pathologies. Notably in cancer, CTSS shown to promote tumour progression, primarily through facilitating invasion and migration cells augmenting angiogenesis. Whilst an attractive therapeutic target, more efficacious inhibitors are required. Here, we investigated potential application Variable New Antigen Receptors (vNARs) as novel inhibitory strategy. A panel vNAR binders were identified...
Abstract Whilst antibody drug conjugates (ADCs) have been successfully used to target highly potent cytotoxic agents tumours, there is a continued emphasis on developing technologies for improving the therapeutic effectiveness of this class agents. The vast majority ADCs that entered clinic based large intact immunoglobulins, however, significant interest in exploiting small protein domains as payload delivery vehicle. These offer number potential benefits over full length antibodies...
Abstract The onco-embryonic receptor tyrosine kinase ROR1is a cell-surface protein expressed on broad range of solid tumours and haematological malignancies but is largely absent from normal adult tissue. Increased ROR1 expression correlates with poor clinical outcome in number cancer indications, consistent its functional role tumorigenesis disease progression. In addition, elevated has been associated increased metastatic potential drug resistance breast non-small cell lung cancer....