Microbial infections lead to elevated inflammatory responses, which usually result in prolonged and incomplete wound healing. Therefore, there is an increasing demand for biodegradable fibres that are effective against a different range of microorganisms, especially those with antibiotic resistance. Herein, quercetin-(Q)-loaded polylactide-based were developed using the electrospinning technique. Since Q exhibits low chemical stability, we used star-shaped polylactides (PLAs) β-CD core host...

A novel and simple method for the preparation of linear, high-molar-mass, thermally stable polylactide stereocomplexes (sc-PLA) with multiwalled carbon nanotubes (MWCNTs) covalently attached to enantiomeric PLA chains is presented. The MWCNTs modified organic spacers terminated −OH groups were used as initiators ring-opening polymerization (ROP) l- d-lactides. weight percentage in final was approximately 1 wt %. nascent (as-polymerized) polymer samples obtained by ROP bulk at 130 °C...

The development of suitable drug delivery systems for prolonged action against HIV receives great attention in recent research. Herein, a long-acting injectable (LAI) Tenofovir alafenamide-chitosan polymeric nanoparticles loaded oleogels developed with sesame oil and ethyl cellulose release the is reported first time. research resulted unique parenteral formulation chronic anti-retroviral therapy, based on our experimental in-vitro ex-vivo studies. chitosan 49 % content were produced through...

The discovery of stereocomplexation, secondary interaction between enantiomeric poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA) provides a method for the creation novel biomaterials with distinctive chemical physical stability. Stereocomplexation opens new way preparation diverse micro- nanostructures such as uniform microspheres, hollow particles, micelles, nanocrystals, nanofibres, nanotubes polymerosomes. Herein, we describe design stereocomplex assemblies specific applications methods...

The controlled ring-opening polymerization of l-lactide and d-lactide using 2-aminopyridine (AP), isocytosine (IC), uridine (U), 2-ureido-4[1H]-pyrimidinone (UPy-OH) initiators with stannous(II) octanoate as catalyst leads to polylactides (AP-PLA-OH, IC-PLA-OH, U-PLA-OH, UPy-PLA-OH), which are capable forming strong hydrogen bonds consequently self-assemble. By means "1H NMR titration", the association constant (Ka) was determined for chosen model system composed aminopyridine end groups....

Abstract Molar mass correction coefficients (cc) were determined for calculating the absolute molar masses of polylactide (PLA), polycaprolactone (PCL), and poly(2,2‐dimethyltrimethylene carbonate) (PDTC) in range 2,5–190 kg/mol, using calibration based on polystyrene standards (PS). Linear PLAs, PCLs, PDTCs with a wide synthesized tin (II) octoate diol as catalyst/initiator system. Size Exclusion Chromatography (SEC) coupled Refractive Index detector (SEC‐RI) or Multi‐Angle Laser Light...

Graft copolymers of polylactide and oligo(methyl methacrylate) (PLA-g-MMA) were synthesized by atom transfer radical polymerization (ATRP) methyl methacrylate (MMA) using PLA containing 10 mol % acetal units functionalized with bromine or chlorine moieties as a multisite macroinitiator. The ultimate aim was to improve the miscibility PMMA preparing graft copolymers. MMA chosen model vinyl monomer investigate whether presented method allows synthesis required controlled topology molecular...

The potential anticancer drug for leukemia, butane-1,4-diyl bis(2,2,2-trifluoroethane-1-sulfonate) (BFS), C 8 H 12 F 6 O S 2 , a fluorine analogue of busulfan, was synthesized and analyzed the first time using various experimental theoretical techniques, including NMR spectroscopy, single-crystal X-ray diffraction, thermochemistry computational methods. Crystallographic analysis revealed that BFS crystallizes in monoclinic space group P 1 / n with its structure stabilized by covalent...

Abstract This review presents use of the microfluidics technique for preparation polylactide (PLA) based particles developing novel drug delivery systems. Droplet‐based allow uniform single, double and higher order emulsions to be generated that yield highly microspheres, microcapsules polymersomes. Typically, building blocks these complex microparticle systems are PLA macromolecules, their copolymers with different comonomers recently stereocomplexes composed an equimolar mixture poly( l...

Lung cancer is the leading cause of death because smoking and air pollution. Therefore, new ideas should be provided for lung treatment in which delivery anticancer drugs to local tumor site can achieved. For this purpose, we propose use stereocomplexed spherical microspheres with sizes between 0.5 10 μm loaded doxorubicin (DOX) administered through nasal route. In order gain control over microsphere morphology, size, drug loading capacity, systematically studied influence solvent used...

Catheter-associated urinary tract infections (CAUTI) are a common complication associated with catheterization, leading to urosepsis, bacteriuria, and septicaemia. The present work focuses on 3D printing catheter anti-infective properties using various concentrations of polyvinyl alcohol (PVA, e.g., 6-8 %), sodium alginate (NaAlg, e.g. 1-4 methylcellulose (MC, 5 polyethylene glycol (PEG, %) impregnated secnidazole, an antibiotic acting against Gram-negative bacteria. To produce suitable...

Abstract This review summarizes the use of cellulose and polylactide for medical applications with particular emphasis on modern dressings. Although classic cotton viscose dressings are still available popular, usefulness new forms (Cel) its derivatives opens wound treatment options. Therefore, trends in functionalizing traditional dressings, including products made bacterial cellulose, from derivatives, discussed. Polylactide (PLA), turn, is a biodegradable biocompatible polyester that...

Biocompatible and biodegradable stereocomplexed micelles (SCMs) based on polylactides (PLAs) with β-cyclodextrin (β-CD) core were designed used as efficient intracellular drug carriers. The formation, stability release behavior of enantiomeric β-CD systematically investigated in comparison to the composed PLAs dipentaerythritol (DPE) core. presence allows for formation inclusion complex a model anticancer drug: doxorubicin (DOX), whereas stereocomplexation between PLLA PDLA enhanced obtained...

Abstract Low‐molecular‐weight polymers of L ‐ and D ‐lactide containing different end‐groups (hydroxy, butoxy, trifluoromethoxy, heptafluorobutoxy, oxyethylimidazole groups, groups derived from the imidazolium ionic liquid) are synthesized. It is shown that nature affects stereocomplexation corresponding pairs polymers. Stereocomplex poly( ‐lactide) liquid (PLA‐IL) precipitates 1,4‐dioxane solution in form monodisperse, perfectly spherical microspheres. Such behavior PLA‐IL, not observed for...

In this paper, the combined effect of influence polylactide (PLA) end‐group nature and PLA architecture on morphology stereocomplexes formed during precipitation from organic solvent is investigated. Stereocomplexation star‐shaped poly( l ‐lactide) linear d functionalized with imidazolium ionic liquid end groups in 1,4‐dioxane leads to formation uniform microspheres, which are able crystallize form colloidal crystals. Microscopic scanning electron microscopy (SEM) atomic force (AFM) analysis...