A5053153140- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Extracellular vesicles in disease
- Bacterial Infections and Vaccines
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- Clostridium difficile and Clostridium perfringens research
- HIV Research and Treatment
- Genital Health and Disease
- Medical and Biological Sciences
- Immune Response and Inflammation
- Systemic Sclerosis and Related Diseases
- vaccines and immunoinformatics approaches
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Craniofacial Disorders and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organ and Tissue Transplantation Research
- Respiratory and Cough-Related Research
University of Pittsburgh
2019-2023
Extracellular vesicles (EVs) are increasingly appreciated as a mechanism of communication among cells that contribute to many physiological processes. Although EVs can promote either antiviral or proviral effects during viral infections, the role in virus-associated polymicrobial infections remains poorly defined. We report secreted from airway epithelial respiratory infection secondary bacterial growth, including biofilm biogenesis, by Pseudomonas aeruginosa. Respiratory syncytial virus...
According to current standards, no existing patient-reported outcome (PRO) measures have high-quality validity evidence for use with individuals diagnosed paediatric localized scleroderma (LS). This severely hinders patient-centred LS-focused research, including much needed clinical trials.
Miscommunication of antiviral and antibacterial immune signals drives worsened morbidity mortality during respiratory viral-bacterial coinfections. Extracellular vesicles (EVs) are a form intercellular communication with broad implications infection, here we show that epithelium-derived EVs released the response impair activity macrophages, an innate cell crucial for bacterial control in airway. Macrophages exposed to display reduced clearance
Rhinovirus (RV)-specific surveillance studies in the Middle East are limited. Therefore, we aimed to study clinical characteristics, outcomes, and seasonality of RV-associated acute respiratory infection among hospitalized young children Jordan. We conducted a prospective viral enrolled <2 years old admitted large public hospital Amman, Jordan (2010-2013). Demographic data were collected by structured interviews chart abstractions. Nasal and/or throat swabs tested for panel viruses, RV...