A5002075276- Air Quality and Health Impacts
- Air Quality Monitoring and Forecasting
- Energy and Environment Impacts
- Noise Effects and Management
- Asthma and respiratory diseases
- Indoor Air Quality and Microbial Exposure
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genomics, phytochemicals, and oxidative stress
- Vehicle emissions and performance
- Viral Infectious Diseases and Gene Expression in Insects
- Pediatric health and respiratory diseases
- Herbal Medicine Research Studies
- Dermatology and Skin Diseases
- Congenital Diaphragmatic Hernia Studies
- Dental Erosion and Treatment
- Smoking Behavior and Cessation
- Dental Anxiety and Anesthesia Techniques
- Esophageal and GI Pathology
- Mast cells and histamine
- Tracheal and airway disorders
- Dental Health and Care Utilization
- Gastrointestinal disorders and treatments
- Allergic Rhinitis and Sensitization
- Mycotoxins in Agriculture and Food
- Occupational and environmental lung diseases
Universidade de São Paulo
2012-2024
Determining the factors associated with NCCLs and DH in populations could guide implementation of specific preventive measures. This study evaluated clinical features non-carious cervical lesions (NCCLs) dentin hypersensitivity (DH) a Brazilian population. The participants were 118 patients at Dentistry Clinic our dental school. They completed an interview to obtain personal information determine possible DH. Clinical examination was undertaken record NCCLs, shape lesion certain occlusal...
K. Yoshizakia, J. M Britoa, A. C. Toledob, N. Nakagawac, V. S. Piccina, M. Junqueirad, E. Negria, L. Carvalhoe, P. Ligeiro de Oliveiraf, W. Tavares Limaf, H. Saldiva, T. Mauad & Macchione*aa Laboratory of Experimental Atmospheric Pollution (LPAE), University Sao Paulo, Brazilb Therapeutics (LIM20), Brazilc Department Physiotherapy, Brazild Animal Facility, Brazile Pathology, School Medicine, Brazilf Pharmacology, Institute Biomedical Sciences, Brazil
Abstract Diesel exhaust particles (DEP) are known to generate reactive oxygen species in the respiratory system, triggering cells activate antioxidant defence mechanisms, such as Keap1-Nrf2 signalling and autophagy. The aim of this study was investigate relationship between autophagy pathways after DEP exposure. BEAS-2B were transfected with silencing RNA (siRNA) specific Nrf2 exposed DEP. relative levels mRNA for Nrf2, NQO1, HO-1, LC3B, p62 Atg5 determined using RT-PCR, while LCB3, protein...
Asthma allergic disease is caused by airway chronic inflammation. Some intracellular signaling pathways, such as MAPK and STAT3-SOCS3, are involved in the control of inflammation asthma. The flavonoid sakuranetin demonstrated an anti-inflammatory effect different asthma models. Our aim was to clarify how treatment affects STAT3-SOCS3 pathways a murine experimental model. Mice were submitted ovalbumin-induction protocol treated with vehicle, sakuranetin, or dexamethasone. We assayed...
Diesel exhaust particles (DEPs) are deposited into the respiratory tract and thought to be a risk factor for development of diseases system. In healthy individuals, timing mechanisms injuries caused by chronic exposure air pollution remain clarified.We evaluated effects DEP at doses below those found in typical bus corridor Sao Paulo (150 μg/m3). Male BALB/c mice were divided receiving nasal instillation: saline (saline; n = 30) 30 μg/10 μL (DEP; 30). Nasal instillations performed five days...
Ambient particles may undergo modifications to their chemical composition as a consequence of climatic variability. The determination whether these changes modify the toxicity is important for understanding health effects associated with particle exposure. objectives were determine low levels promote cardiopulmonary effects, and assess if observed alterations are influenced by season. Mice exposed 200 μg/m(3) concentrated ambient (CAPs) filtered air (FA) in cold/dry warm/humid periods. Lung...
The prevalence of fragrances in various hygiene products contributes to their sensorial allure. However, can induce sensitization the skin or respiratory system, and mechanisms involved this process are incompletely understood. This study investigated intricate underlying fragrance's effects on response, focusing interplay between CYP450 enzymes, a class drug-metabolizing adaptive immune system. Specifically, we assessed expression enzymes cytokine profiles culture BEAS-2B mature dendritic...
Diesel Exhaust Particles (DEP) are one of the sources ultrafine particle inhaled daily and it has been linked to respiratory diseases, due its ability generate oxidative stress cause cell death in airways. To protection, airway epithelium activates antioxidant defense mechanisms, which Nrf2-Keap1 system is an important inductor cytoprotective enzymes, as NQO1 HMOX1. The aim this study investigate relationship between human bronchial cells exposed DEP. For purpose, we used immortalized line...
<b>Background:</b> Adults´ and childrens´ severe asthma are considered as distinct phenotypes. A recent study has shown that mast cells associated with exacerbations in children (Lezmi, G <i>et al</i>. ERJ 2016). Differences cell number spatial distribuition the bronchial wall between adults have not been assessed yet. <b>Aim:</b> To analyze subtypes epithelial layer (EL), lamina propria (LP) airway smooth muscle bundles (Asm) of biopsies taken from after optimal treatment. <b>Methods:</b>...
Several differences are found in human gender with respect to risk, incidence and pathogenesis lung disease but still is difficult indentify if female have more damage when exposed air pollution. The objective of this study was identify some injury markers such as inflammatory cells IL-1β, IL-17, TGF-α, TNF-α, MMP-9, COX-2, protein receptor IL-8R trachea hiperrresponsiveness male mice, concentrated ambient particles(CAPs) air. Thirty-two 105 BALB/c young adult mice were given early exposure...
Hypersecretion is recognized as an importan feature in asthma. Besides the alteration airway epithelium, asthma frequent associated to changes nasal epithelium. Previously, we demonstrated that sakuranetin, a flavonoid derived from plant called Baccharis Retusa reduced inflammation and remodeling improving lung function. <b>Aims:</b> To evaluate whether sakuranetin treatment interferes with bronchial epithelial alterations model. <b>Methods:</b> BALB/c mice received ovalbumin (OVA) (ip) on...