A5049964612- Retinal Diseases and Treatments
- Circadian rhythm and melatonin
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Diet and metabolism studies
- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Retinal and Optic Conditions
- Pancreatic and Hepatic Oncology Research
- Signaling Pathways in Disease
- Thermoregulation and physiological responses
- Retinoids in leukemia and cellular processes
- Music Therapy and Health
- Connexins and lens biology
- Renal function and acid-base balance
- Metabolism and Genetic Disorders
- Genetic factors in colorectal cancer
- Glaucoma and retinal disorders
- Dietary Effects on Health
- GDF15 and Related Biomarkers
- Chronic Kidney Disease and Diabetes
- TGF-β signaling in diseases
- Sodium Intake and Health
- Sarcoma Diagnosis and Treatment
- Retinal and Macular Surgery
Life Extension Foundation
2019-2020
Indiana University School of Medicine
2018-2019
Indiana University – Purdue University Indianapolis
2018-2019
Centre Hospitalier Universitaire de Reims
2017
Université de Reims Champagne-Ardenne
2017
University of Miami
2008-2013
Miami Dermatology and Laser Institute
2011-2013
Molecular Oncology (United States)
2009
Centre hospitalier universitaire de Québec
2003
Foederatio Medicorum Helveticorum
2000
Background Age-related macular degeneration (AMD) is the leading cause of legal blindness in elderly population. Debris (termed drusen) below retinal pigment epithelium (RPE) have been recognized as a risk factor for dry AMD and its progression to wet AMD, which characterized by choroidal neovascularization (CNV). The underlying mechanism how drusen might elicit CNV remains undefined. Cigarette smoking, oxidative damage RPE inflammation are postulated be involved pathophysiology disease. To...
Purpose.: Cigarette smoking is the strongest environmental risk factor for wet age-related macular degeneration (AMD). Inappropriate expression of proangiogenic vascular endothelial growth (VEGF) and antiangiogenic pigment epithelium derived (PEDF) may cause choroidal neovascularization (CNV), a key event in AMD, resulting vision loss. Nicotine (NT), potent angiogenic agent abundant second-hand smoke, play major role pathogenesis AMD. The purpose this study was to evaluate nicotinic...
Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous causes in mice.
This pilot randomised controlled study evaluated the effects of a nutrient-supported intermittent energy restriction nutrition programme to prevent weight gain in healthy overweight adults during 6-week winter holiday period between Thanksgiving and New Year. For 52 d, twenty-two (mean age 41·0 years, BMI 27·3 kg/m2) were assigned either (n 10; two fasting days 730 kcal/d (3050 kJ/d) balanced shake dietary supplements support management efforts, followed by 5 d habitual diet) or control...
GDF11 modulates embryonic patterning and kidney organogenesis. Herein, we sought to define function in the adult renal diseases.In vitro cell lines, genetic, murine vivo injury models were examined.Among tissues tested, Gdf11 was highest normal mouse kidney. Expression increased acutely after 5/6 nephrectomy, ischemia-reperfusion injury, kanamycin toxicity, or unilateral ureteric obstruction. Systemic, high-dose administration mice led failure, with accompanying atrophy, interstitial...
<b><i>Purpose:</i></b> To investigate the in vitro effect of vital dyes on toxicity and apoptosis a human retinal pigment epithelial cell line. <b><i>Methods:</i></b> ARPE-19 cells were exposed to brilliant blue (BBG), Evans Blue (EB), bromophenol (BroB), indocyanine green (ICG), infracyanine (IfCG), light (LG), fast (FG), indigo carmine (IC) Congo red (CR). Balanced salt solution was used as control. Five different concentrations 2 exposure...
Purpose To investigate the in vitro effect of four vital dyes on toxicity and apoptosis a human retinal pigment epithelial (RPE) cell line. Methods ARPE-19 cells were exposed to brilliant blue (BriB), methyl (MetB), acid violet (AcV) indocyanine green (ICG). Balanced salt solution was used as control. Five different concentrations each dye (1, 0.5, 0.25, 0.05 0.005 mg/mL) two exposure times (3 30 min) tested. Cell viability determined by count MTS assay LDH assay. Real-time PCR Western...
Circadian changes in renal hemodynamics and urinary glycosaminogly-can (GAG) excretion were studied normal Sprague-Dawley rats to further investigate rhythms kidney function. Urinary water, protein, GAG excretion, as well glomerular filtration rate (GFR) plasma flow (RPF), determined every 4h over the 24h cycle an attempt characterize any temporal changes. proteinuria peaked during dark activity period of animals, consistently at same hour, whereas lowest values detected resting phase. are...
Patients with secondary hypertension frequently display abnormal circadian blood pressure profiles, characterized by a failure to decrease at night. The transgenic TGR(mRen-2)27 rat strain, developing fulminant after the mouse salivary Ren-2 renin gene has been integrated into its genome, provides fundamental model of genetic hypertension. Because an inverse profile and unchanged rhythmic pattern heart rate compared normotensive Sprague-Dawley (SPR) it was proposed serve as animal It aim...
Catheters were placed in the jugular vein and femoral artery of male Sprague-Dawley rats connected to a specially designed perfusor for continuous constant infusion 0.9% NaCl syringe perform simultaneous intermittent blood collections. This permitted 24-h study renal hemodynamics, estimated by inulin (Cin) p-amino-hippuric acid (CPAH) clearances; Cin represents glomerular filtration rate CPAH plasma flow. Animals individually housed metabolism cages controlled environment with light/dark...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy with high rates of cachexia. Serum activin correlates PDAC cachexia and mortality, while administration causes in mice. We studied human tumors mice orthotopic or genetic PDAC. Cachexia severity correlated expression tumor lines. Activins were expressed both cancer stromal cells, but also organs murine Tumor cells activin-βA, Inhba , activin-βA activin-βB, Inhbb . elicits expression; conditioned medium...
Background Nocturia is the most bothersome lower urinary tract symptoms (LUTS) and can significantly reduce men's quality of life. It often poorly managed with conventional treatments. Objective The purpose this study was to evaluate self-assessed benefits a prostate health dietary combination formulation on mild LUTS, especially nocturia in healthy males. Methods In an open label clinical study, thirty male subjects LUTS took one daily capsule product for 60 days. primary outcome severity...