A5101487068- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- DNA Repair Mechanisms
- ATP Synthase and ATPases Research
- Chemical Reactions and Isotopes
- Pancreatic and Hepatic Oncology Research
- Metalloenzymes and iron-sulfur proteins
- Cytokine Signaling Pathways and Interactions
- Biochemical and Molecular Research
- Cancer therapeutics and mechanisms
- Liver physiology and pathology
- Cancer Mechanisms and Therapy
- Nutrition and Health in Aging
- Microtubule and mitosis dynamics
- Advanced Breast Cancer Therapies
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Enzyme function and inhibition
- Metabolism, Diabetes, and Cancer
- Wave and Wind Energy Systems
- Cancer Treatment and Pharmacology
- solar cell performance optimization
- Intracerebral and Subarachnoid Hemorrhage Research
Affiliated Zhongshan Hospital of Dalian University
2018-2025
Wuhan University of Technology
2023-2024
University of Alabama at Birmingham
2019-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2024
Guilin Medical University
2019-2022
Indiana University – Purdue University Indianapolis
2006-2021
Indiana University School of Medicine
2006-2021
Pediatric Nephrology of Alabama
2019
First Affiliated Hospital of Henan University of Science and Technology
2019
Dalian Medical University
2015-2017
Most patients with pancreatic adenocarcinoma (PDAC) suffer cachexia; some do not. To model heterogeneity, we used patient-derived orthotopic xenografts. These phenocopied donor weight loss. Furthermore, muscle wasting correlated mortality and murine IL-6, human IL-6 associated the greatest cachexia. In cell culture mice, PDAC cells elicited adipocyte expression plus receptor (IL6R) in myocytes blood. induced lipolysis steatosis, dysmetabolism, wasting. Depletion of from malignant halved...
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality in United States. Aggressive treatment regimens have not changed disease course, and median survival has just recently reached a year. Several mechanisms are proposed to play role PDAC therapeutic resistance, including hypoxia, which creates more aggressive phenotype with increased metastatic potential impaired efficacy. AP Endonuclease-1/Redox Effector Factor 1 (APE1/Ref-1) multifunctional...
Acute kidney injury (AKI) is a devastating clinical condition affecting at least two-thirds of critically ill patients, and, among these it associated with greater than 60% risk mortality. Kidney mononuclear phagocytes (MPs) are implicated in pathogenesis and healing mouse models AKI thus, have been the subject investigation as potential targets for intervention. We determined that, after injury, F4/80hi-expressing kidney-resident macrophages (KRMs) distinct cellular subpopulation that does...
Although chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of platinum drugs, the mechanisms this toxicity remain unknown. Previous work in our laboratory suggests that cisplatin-induced CIPN secondary to DNA damage which susceptible base excision repair (BER). To further examine hypothesis, we studied effects cisplatin, oxaliplatin, and carboplatin on cell survival, damage, ROS production, functional endpoints rat sensory neurons culture absence or presence...
Abstract Peripheral neuropathy is one of the major side effects anticancer drug cisplatin. Although previous work suggests that this correlates with formation DNA adducts in sensory neurons, growing evidence cisplatin also increases generation reactive oxygen species (ROS), which could cause damage. Apurinic/apyrimidinic endonuclease/redox factor-1 (Ape1/Ref-1) a multifunctional protein involved base excision repair oxidative damage and redox regulation number transcription factors....
Abstract Pancreatic cancer is especially a deadly form of with survival rate less than 2%. cancers respond poorly to existing chemotherapeutic agents and radiation, progress for the treatment pancreatic remains elusive. To address this unmet medical need, better understanding critical pathways molecular mechanisms involved in tumor development, progression, resistance traditional therapy therefore critical. Reduction–oxidation (redox) signaling systems are emerging as important targets...
Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous causes in mice.
<title>Abstract</title> Objective UBR2 (also referred to as n-recognin 2, the E3 component of ubiquitin protein ligase) targets proteins with unstable N-terminal residues for polyubiquitination and proteasome-mediated degradation. It was initially identified a crucial oncogene during embryonic development. Nevertheless, function in triple-negative breast cancer (TNBC) its non-ubiquitination role, particularly suppressing antitumor immune responses, remain elusive. Methods Utilizing bulk RNA...
The structural assessment of offshore floating photovoltaic platforms (OFPVPs) has long been a critical focus in engineering. Traditional methods usually involve mapping loads from hydrodynamic model to finite element (FEM) one-way process. However, and analyses are typically treated as separate processes. In contrast, the present integrates FEM with static condensation method couple models. This is accomplished by solving frequency-domain multi-body equation motion, which combines condensed...
Pancreatic cancer is a deadly disease that virtually never cured. Understanding the chemoresistance intrinsic to this will aid in developing new regimens. High expression of APE1/Ref-1, DNA repair and redox signaling protein, associated with resistance, poor outcome, angiogenesis; little known pancreatic cancer. Immunostaining adenocarcinoma shows greater APE1/Ref-1 than normal pancreas tissue. A decrease protein levels results cell growth inhibition, increased apoptosis, altered cycle...
Constitutively activated STAT3 protein has been found to be a key regulator of pancreatic cancer and target for molecular therapeutic intervention. In this study, PG-S3-001, small molecule derived from the SH-4-54 class inhibitors, was inhibit patient-derived cell proliferation in vitro vivo low micromolar range. PG-S3-001 binds potently, Kd = 324 nmol/L by surface plasmon resonance, showed no effect kinome screen (>100 cancer-relevant kinases). studies demonstrated potent killing as well...
Angiogenesis is a vital endogenous brain self-repair processes for neurological recovery after intracerebral hemorrhage (ICH). Increasing evidence suggests that leptin potentiates angiogenesis and plays beneficial role in stroke. However, the proangiogenic effect of on ICH has not been adequately explored. Moreover, triggers post-ICH through pericyte, an important component forming new blood vessels, which remains unclear. Here, we reported exogenous infusion dose-dependent promoted vascular...
// Dan Wang 1, * , Kebang Hu 2, Ningning Gao 3 Hao Zhang 1 Yanlin Jiang Caigang Liu Shouyu 4 Zuowei Zhao Breast Disease and Reconstruction Center, Cancer Key Lab of Dalian, The Second Hospital Dalian Medical University, China 116023 2 Department Urology, First Jilin Changchun, 130021 Ultrasonic Diagnosis Department, Shenyang, 110001 Surgery, the first 114000 These authors have contributed equally to this work Correspondence to: Liu, e-mail: angel-s205@163.com Wang, xiaomingjints@163.com...
Hepatic steatosis is a common histological finding in obese patients. Even mild associated with delayed hepatic regeneration and poor outcomes following liver resection or transplantation. We sought to identify target molecular pathways that mediate this dysfunction. Lean mice made through feeding of high-fat, hypercaloric diet underwent 70 80% hepatectomy. After 70% resection, demonstrated 100% survival but experienced increased injury, reduced energy stores, mitoses, necroapoptosis,...
Resident memory T cells (T
We aimed to develop a new nomogram predict the probability of level 2 axillary lymph node metastasis (L-2-ALNM) in breast cancer (BC) patients treated with neoadjuvant chemotherapy (NAC).Data were collected from 709 who received and then underwent (ALN) dissection between May 2009 December 2015 at Liaoning Cancer Hospital. The (L-2-ALNM ) was created logistic regression model. An additional set 141 consecutive same institution January enrolled as validation group. predictive accuracy...