A5027905429- Prostate Cancer Treatment and Research
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Vascular Tumors and Angiosarcomas
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
- Influenza Virus Research Studies
- Renal Transplantation Outcomes and Treatments
- Advancements in Semiconductor Devices and Circuit Design
- Estrogen and related hormone effects
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Renal cell carcinoma treatment
- Radiopharmaceutical Chemistry and Applications
- CAR-T cell therapy research
- Silicon Carbide Semiconductor Technologies
- Immunotherapy and Immune Responses
- Urologic and reproductive health conditions
- Autopsy Techniques and Outcomes
- Dendrimers and Hyperbranched Polymers
First Hospital of Jilin University
2015-2025
Jilin University
2014-2025
Polydopamine nanoparticles camouflaged with stem cell membranes could effectively target tumor sites and showed excellent performance in synergistic chemoimmunotherapy for PCa bone metastases.
Clear cell renal carcinoma (ccRCC) is the predominant human cancer with surging incidence and fatality lately. Hyperactivation of hypoxia-inducible factor (HIF) mammalian target rapamycin (mTOR) signaling are common signatures in ccRCC. Herein, we employed spontaneous ccRCC model to demonstrate indispensability an underappreciated Ser/Thr kinase, CDKL3, initiation progression Ablation CDKL3 does not affect normal kidney, but abrogates Akt-mTOR hyperactivity thoroughly prevents formation...
Background . Prostate multiparametric magnetic resonance imaging is widely recommended prior to biopsy in clinical practice, with the Imaging Reporting and Data System (PI-RADS) as standard tool for guiding diagnosis treatment decisions. However, analyzing data demands substantial expertise, process often time-intensive cognitively challenging, leading variability between within readers. Aim To create a deep learning-based computer-aided (DL-CAD) system minimize manual influence on PI-RADS...
// Dan Wang 1, * , Kebang Hu 2, Ningning Gao 3 Hao Zhang 1 Yanlin Jiang Caigang Liu Shouyu 4 Zuowei Zhao Breast Disease and Reconstruction Center, Cancer Key Lab of Dalian, The Second Hospital Dalian Medical University, China 116023 2 Department Urology, First Jilin Changchun, 130021 Ultrasonic Diagnosis Department, Shenyang, 110001 Surgery, the first 114000 These authors have contributed equally to this work Correspondence to: Liu, e-mail: angel-s205@163.com Wang, xiaomingjints@163.com...
Introduction: Immune regulatory small molecule JQ1 can block its downstream effector PD-L1 pathway and effectively reverse the upregulation induced by doxorubicin (DOX). So synergistic administration of chemotherapeutic drug DOX is expected to increase sensitivity tumors immune checkpoint therapy jointly enhance body's own immunity, thus killing tumor cells. Therefore, a delivery system loaded with was devised in this study. Methods: Polydopamine nanoparticles (PDA NPs) were synthesized...
Prostate cancer is the second most common in men worldwide. This study focused to clarify roles of Metadherin (MTDH) and miR-342-3p prostate cancer. We identified that MTDH was up-regulated down-regulated tissues, there an inverse correlation between miR-342-3p. Functional studies revealed directly targets via binding 3' untranslated regions (UTRs) cells. Moreover, we also found overexpression DU145 PC3 cells inhibited apoptosis. Subsequently, has been reverse effect on cellular apoptosis...
To determine the number of CD4(+)CD25(-)Foxp3(+), CD4(+)CD25(+)Foxp3(+) and CD4(+)CXCR5(+)Foxp3(+) T cells in renal transplant recipients that are transplanted stable (TS), or experiencing accelerated rejection (ALR), acute (AR).Renal transplantation was conducted 28 patients with end-stage failure (ESRF). The peripheral CD4(+)CD25(+)Foxp3(+), serum levels interleukin-10 (IL-10) were measured pre- post-transplant these results compared to 10 healthy controls (HC). Correlation between...
Prostate cancer (PCa) is a common malignant tumor in elderly men worldwide. Most primary PCas inevitably progress into castration-resistant prostate (CRPC) after androgen deprivation therapy. The mechanisms contributing to this progression are still controversial. In study, functional module genes, DNA methylations, core regulators, and potential drugs PCa CRPC were explored by integrating series of bioinformatics analyses. First, 588 differentially expressed genes (DEGs) identified....