A5102893940- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- CAR-T cell therapy research
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Urologic and reproductive health conditions
- Breast Cancer Treatment Studies
- Nanoplatforms for cancer theranostics
- Multiple and Secondary Primary Cancers
- Cardiovascular Disease and Adiposity
- Anorectal Disease Treatments and Outcomes
- Cancer Cells and Metastasis
- Uterine Myomas and Treatments
- AI in cancer detection
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Obesity, Physical Activity, Diet
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Treatments and Studies
- Bladder and Urothelial Cancer Treatments
Sechenov University
2023-2025
SRI International
2021
Menlo School
2021
Pilonidal sinus disease (PSD), also known as pilonidal disease, is a common chronic disorder in coloproctology and general surgery. It predominantly affects young male patients typically located the sacrococcygeal region. Nowadays, various approaches are used to address this condition, but no consensus on gold standard has been established. The aim of study was analyse assess current PSD practice, diagnostic surgical approaches, training attitudes among Russian surgeons. A comprehensive...
Background . Prostate multiparametric magnetic resonance imaging is widely recommended prior to biopsy in clinical practice, with the Imaging Reporting and Data System (PI-RADS) as standard tool for guiding diagnosis treatment decisions. However, analyzing data demands substantial expertise, process often time-intensive cognitively challenging, leading variability between within readers. Aim To create a deep learning-based computer-aided (DL-CAD) system minimize manual influence on PI-RADS...
Pelvic malignancies consistently pose significant global health challenges, adversely affecting the well-being of male population. It is anticipated that clinicians will continue to confront these cancers in their practice. Nanomedicine offers promising strategies revolutionize treatment pelvic by providing precise delivery methods aim improve efficacy therapeutic outcomes while minimizing side effects. Nanoparticles are designed encapsulate agents and selectively target cancer cells. They...
Abstract Background Colon cancer is a global health concern, ranking fifth in both new diagnoses and deaths among tumors worldwide. Surgical intervention remains the primary treatment for localized cases, with historical evolution marked by focus on short-term outcomes. While Japan pioneered radical tumor removal systematic categorization of lymph nodes (D1, D2, D3), dissemination Japanese practices to West was delayed until 90th last century. Discrepancies between D3 dissection CME CVL...
Recent studies have introduced the weight-adjusted waist circumference index (WWI) as a viable obesity indicator that may better reflect centripetal and its associated risks. In examining connection between WWI prostate-specific antigen (PSA), this study leveraged data from National Health Nutrition Examination Survey 2003-2010, including 5732 participants. Our initial analysis indicated significant positive association PSA levels. However, subsequent models adjusted for covariates such age,...
Background Potential uncertainties and overtreatment exist in adjuvant chemotherapy for triple-negative breast cancer (TNBC) patients. Objectives This study aims to explore the performance of deep learning (DL) models personalized selection quantify impact baseline characteristics on treatment efficacy. Methods Patients who received recommended by were compared those did not. Overall survival according model recommendations was primary outcome. To mitigate bias, inverse probability weighting...
The population in Western countries differs significantly from that Eastern countries, and the prevalence of lateral pelvic lymph node (LPLN) involvement populations remains largely unknown due to limited application LPLN dissection (LPLND). This discrepancy is primarily attributed higher body mass index commonly observed populations, which increases risk intraoperative complications. Consequently, aim this study describe a specific clinico-radiological selection tool for LPLND, namely,...
Aim: to evaluate the outcomes of surgical treatment patients with multiple primary cancer colon and prostate. Materials methods. An observational retrospective study was conducted at Clinic Coloproctology Minimally Invasive Surgery (I.M. Sechenov First Moscow State Medical University). A total 3,640 protocols preoperative multidisciplinary team were studied from July 2018 April 2024. The inclusion criterion diagnosis colorectal prostate cancer. medical documentation collected in database...
Aim. To study and analyze the surgical results prognostic factors accompanying radical nephrectomy combined with venous thrombectomy in renal cancer patients tumor thrombosis. Materials methods . Retrospective analysis of clinical data thrombosis who underwent treatment at Clinic Cardiovascular Surgery Urology I.M. Sechenov First Moscow State Medical University Ministry Health Russia (Sechenov University) from May 2010 to February 2023. Kaplan–Meier was used obtain overall survival curves...
Abstract Despite dedicated research in precision medicine, identification of therapeutic strategies for oncogenic drivers remains a major challenge as many mutations are difficult to target directly. Synthetic lethality-based prediction becomes powerful approach drug discovery. We previously developed computational platform, Mining Lethals (MiSL), that can output list possible synthetic lethal partners specific gene when fed with primary human tumor genomic and transcriptomic data. The...