A5084484678- Advanced Fluorescence Microscopy Techniques
- Photonic and Optical Devices
- Photoreceptor and optogenetics research
- Microfluidic and Capillary Electrophoresis Applications
- Cell Image Analysis Techniques
- Electrowetting and Microfluidic Technologies
- Advanced Fiber Optic Sensors
- Microfluidic and Bio-sensing Technologies
- Photoacoustic and Ultrasonic Imaging
- Optical Coherence Tomography Applications
- Quantum Dots Synthesis And Properties
- Neuroscience and Neural Engineering
- Mechanical and Optical Resonators
- bioluminescence and chemiluminescence research
- Semiconductor Lasers and Optical Devices
- Biosensors and Analytical Detection
- Advanced Fiber Laser Technologies
- Near-Field Optical Microscopy
- Nanowire Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Molecular Junctions and Nanostructures
- Orbital Angular Momentum in Optics
- Laser Design and Applications
- Nanoplatforms for cancer theranostics
Sichuan Agricultural University
2023-2024
SRI International
2024
University of Michigan
2013-2020
Palo Alto Research Center
2020
Michigan United
2013-2019
Nanyang Technological University
2019
Ann Arbor Center for Independent Living
2014-2018
Zhejiang University
2017
We achieved optofluidic protein lasing using genetically encoded fluorescent FRET pairs linked by length-tunable peptides. Up to 25-fold reduction in the donor laser emission was observed when and acceptor were brought close proximity, as compared only 17% conventional detection. Our work opens a door broad range of applications studying protein-protein interactions protein-drug interactions.
Indocyanine green (ICG) is the only near-infrared dye approved by U.S. Food and Drug Administration for clinical use. When injected in blood, ICG binds primarily to plasma proteins lipoproteins, resulting enhanced fluorescence. Recently, optofluidic laser has emerged as a novel tool bio-analysis. Laser emission advantages over fluorescence signal amplification, narrow linewidth, strong intensity, leading orders of magnitude increase detection sensitivity imaging contrast. Here we...
An optofluidic laser with a single molecular layer of gain.
Dual band lasing from an optofluidic chlorophyll laser
We investigate a cadmium sulfide (CdS) nanowire (NW) laser that is spontaneously internalized into single cell to serve as stand-alone intracellular probe.
We present a distributed fibre optofluidic laser based chip-scale arrayed sensor, which paves the way towards high-throughput biochemical sensing.
We have applied self-assembled DNA tetrahedral nanostructures for the precise and tunable control of gain in an optofluidic fluorescence resonance energy transfer (FRET) laser. By adjusting ratio donor acceptor attached to vertices, 3.8 times reduction lasing threshold 28-fold enhancement efficiency were demonstrated. This work takes advantage self-recognition self-assembly capabilities biomolecules with well-defined structures addressability, enabling nano-engineering laser down molecular level.
This paper describes a low-cost fiber optofluidic laser for disposable and array applications using microstructured optical fiber.
DNA lasers self-amplify optical signals from a analyte as well thermodynamic differences between sequences, allowing quasi-digital detection.
Optofluidic lasers are currently of high interest for sensitive intracavity biochemical analysis. In comparison with conventional methods such as fluorescence and colorimetric detection, optofluidic provide a method amplifying small concentration differences in the gain medium, thus achieving sensitivity. Here, we report development an on-chip ELISA (enzyme-linked immunosorbent assay) laser platform that is able to complete assay short amount time sample/reagent volumes, large dynamic range,...
The authors demonstrate a bio-inspired optofluidic laser with luciferin, class of light-emitting compounds synthesized by many different organisms, as the gain medium. characteristics under various conditions such solution pH value and luciferin concentration are investigated. an fluorescence resonance energy transfer using Rhodamine 6G donor acceptor, respectively, which takes advantage large Stokes shift to avoid potential cross excitation acceptor. Their work leads photonic devices...
We achieved two types of laser emissions from aqueous quantum dots (QDs) using the same high-Q-factor optofluidic ring resonator (OFRR) platform. In first type, 2 μM QDs were in bulk buffer solution that filled entire OFRR cavity volume. The lasing threshold was 0.1 μJ/mm2, over 3 orders magnitude lower than state-of-the-art. second type laser, immobilized as a single layer on interface between inner wall and with surface density low × 109–1010 cm–2. 60 μJ/mm2 achieved. both single-layer...
Highly versatile tissue laser platform.
We develop a hybrid optofluidic microcavity by placing microsphere with diameter ranging from 1 to 4 μm in liquid-filled plano-plano Fabry–Perot (FP) cavities, which can provide an extremely low effective mode volume down 0.3–5.1 μm3 while maintaining high Q-factor up 1×104–5×104 and finesse of ∼2000. Compared the pure FP cavities that are known suffer lack confinement, diffraction, geometrical walk-off losses as well being highly susceptible mirror misalignment, our microsphere-integrated...
Incorporating fluorescence resonance energy transfer (FRET) into a laser cavity can increase the sensitivity of FRET-based biochemical sensors due to nonlinear dependence lasing output on FRET parameters. Here, we carry out comprehensive theoretical analysis optofluidic lasers based Fabry-Pérot microcavity using rate equation model. We compare conceptually distinct cases donor and acceptor molecules diffusing freely in bulk solution versus connected by fixed-length linker show that latter...
We developed a chip-scale temperature sensor with high sensitivity of 228.6 pm/°C based on rhodamine 6G (R6G)-doped SU-8 whispering gallery mode microring laser. The optical was largely distributed in polymer core layer 30 μm height that provided detection sensitivity, and the chemically robust fused-silica resonator host platform guaranteed its versatility for investigating different functional materials refractive indices. As proof concept, dye-doped hyperbranched (TZ-001) laser-based...
An optofluidic FRET (fluorescence resonance energy transfer) laser is formed by putting pairs inside a microcavity acting as gain medium. This integration of an and the mechanism provides novel research frontiers, including sensitive biochemical analysis photonic devices, such on-chip coherent light sources bio-tunable lasers. Here, we investigated using quantum dots (QDs) donors. We achieved lasing from Cy5 acceptor in QD-Cy5 pair upon excitation at 450 nm, where has negligible absorption...
Optofluidic ring resonator laser fabricated using 3-D femto-second writing technology.
Automated, high-throughput, and long-term cell laser detection was demonstrated by the integration of microwell arrays Fabry–Pérot cavities.
Laser emission-based detection and imaging technology has attracted significant interest in biomedical research due to its high sensitivity, narrow linewidth, superior spectral spatial resolution.
We report a reproducible optofluidic laser (OFL) for multichannel biochemical sensing. A hollow optical fiber (HOF) serves as both microring resonator lasing and microfluidic channel. The mechanism is analyzed in spectral domain. Thanks to the precise control of geometry rotational symmetry, HOF-OFL emission uniformly distributed angular direction (σ = 0.6%) can be employed conveniently disposable or arrayed use. An array ten OFLs demonstrated with good reproducibility ( σ 3.9%) threshold....