Refractive index (RI) sensors based on optical resonance techniques are receiving a high degree of attention because the need to develop simple, low-cost, high-throughput detection technologies for number applications. While sensing mechanism most reported RI is similar, construction quite different from technique technique. It desirable have uniform comparing various techniques, but date there exists variation as how performance quantified. Here we set forth rigorous definition limit...

We have demonstrated a novel sensor architecture based on liquid-core optical ring-resonator (LCORR) in which fused silica capillary is utilized to carry the aqueous sample and act as ring resonator. The wall thickness of LCORR controlled few micrometers expose whispering gallery mode core. Optical characterization with water-ethanol mixture shows that spectral sensitivity approximately 2.6 nm per refractive index unit. A model Mie theory established explain experimental results. takes...

Abstract Whispering gallery modes (WGMs) have been exploited for a broad range of sensing applications. However, the vast majority WGM sensors consist passive resonators, requiring complex interrogation systems to be employed, ultimately limiting their practicality. Active resonators containing gain medium, allowing remote excitation and collection WGM‐modulated fluorescence spectra, emerged as an alternative resonators. Although research is still in its infancy, recent progress has reduced...

We have developed a highly sensitive refractometric sensor based on fused silica microsphere resonators. The spectral position of the whispering gallery mode (WGM) sphere shifts in response to refractive index change surrounding medium. strong light-matter interaction due extremely high Q factor associated with WGM results sensitivity approximately 30nm∕RIU (refractive units). This, together resolution our system (∼0.01pm), yields detection limit order 10−7RIU. Theoretical calculation is...

We theoretically and experimentally analyze the biomolecule detection capability of liquid core optical ring resonator (LCORR) as a label-free bio/chemical sensor. first establish simple general linear relationship between LCORR's bulk refractive index sensitivity (BRIS) its response to molecule deposition onto surface, which enables us easily characterize LCORR sensing performance. Then, biosensing experiments are performed with bovine serum albumin (BSA) LCORRs various BRISs. The...

We developed highly sensitive and specific nanosensors based on quantum dots (QDs) DNAzyme for multiplexed detection of heavy metal ions in liquid. The QDs were coated with a thin silica layer increased stability higher yield while maintaining relatively small size efficient energy transfer. QD-DNAzyme constructed by conjugating quencher-labeled DNAzymes onto the surface carboxyl-silanized QDs. In presence ions, emission is restored due to cleavage DNAzymes. could be completed within 25 min...

We demonstrate a robust and highly responsive optical microsensor, which probes the refractive index of liquids flowing along ~ 100 mum radius channel formed in polymer matrix. Sensing is based on measurement transmission spectrum whispering gallery modes, are excited across liquid by an microfiber imbedded into polymer. The achieved sensitivity 800 nm/RIU. Potentially, it straightforward to assemble sensing elements this type lab-on-the-chip solidified material.

Optofluidic dye lasers hold great promise for adaptive photonic devices, compact and wavelength-tunable light sources, micro total analysis systems. To date, however, nearly all those are directly excited by tuning the pump laser into gain medium absorption band. Here we demonstrate bioinspired optofluidic FRET, in which donor-acceptor distance, ratio, spatial configuration can be precisely controlled DNA scaffolds. The characteristics of FRET such as spectrum, threshold, energy conversion...

The authors demonstrate a microfluidic dye laser using liquid core optical ring resonator (LCORR). LCORR is made of fused silica capillary with wall thickness few microns. circular cross section the forms that supports whispering gallery modes (WGMs) and provides an feedback for lasers. Due to high Q factor WGM (107), low lasing threshold achieved (1μJ∕mm2). In addition, they show can be coupled out via tapered fiber in touch LCORR, thus providing mechanism easy delivery.

The sensing capability of the capillary-based optofluidic ring resonator in bulk refractive index (RI) detection and label-free small molecule is investigated. In RI detection, a sensitivity 570 nm/refractive units (RIU) achieved with Q-factor 1.2×105. A change 2.8×10−7 RIU observed noise equivalent limit (NEDL) 3.8×10−8 RIU. 10 nM biotin detected surface mass density 1.6 pg/mm2. NEDL approximately 0.14 These results set benchmark for performance compare very favorably those obtained other...

We have demonstrated sensitive label-free virus detection using the opto-fluidic ring resonator (OFRR) sensor. The OFRR is a novel sensing platform that integrates microfluidics and photonic technology with low limit small volume. In our experiment, filamentous bacteriophage M13 was used as safe model system. Virus samples were flowed through whose surface coated M13-specific antibodies. studied sensor performance by monitoring in real-time antibody interaction. It shown can detect high...

Abstract A biolaser utilizes biological materials as part of its gain medium and/or cavity. It can also be a micro‐ or nanosized laser embedded/integrated within materials. The employs lasing emission rather than regular fluorescence the sensing signal and therefore has number unique advantages that explored for broad applications in biosensing, labeling, tracking, contrast agent development, bioimaging. This article reports on progress biolasers with focus work done past five years. In end,...

Currently, optical or mechanical resonances are commonly used in microfluidic research. However, optomechanical oscillations by light pressure were not shown with liquids. This is because replacing the surrounding air water inherently increases acoustical impedance and hence, associated radiation losses. Here, we bridge between microfluidics optomechanics fabricating a hollow-bubble resonator liquid inside optically exciting vibrations 100 MHz rates using only mW optical-input power....

We achieved optofluidic protein lasing using genetically encoded fluorescent FRET pairs linked by length-tunable peptides. Up to 25-fold reduction in the donor laser emission was observed when and acceptor were brought close proximity, as compared only 17% conventional detection. Our work opens a door broad range of applications studying protein-protein interactions protein-drug interactions.