A5015475805- Synthesis and biological activity
- Quinazolinone synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Mechanisms and Therapy
- Cancer therapeutics and mechanisms
- Angiogenesis and VEGF in Cancer
- Melanoma and MAPK Pathways
- Bioactive Compounds and Antitumor Agents
- Synthesis of Tetrazole Derivatives
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Synthesis and Catalytic Reactions
- Multicomponent Synthesis of Heterocycles
- Enzyme function and inhibition
- PI3K/AKT/mTOR signaling in cancer
- Synthesis and Characterization of Pyrroles
- Aldose Reductase and Taurine
- Click Chemistry and Applications
Mansoura University
2015-2025
Cancer remains a leading cause of death worldwide, often resulting from uncontrolled growth in various organs. Protein kinase inhibitors represent an important class targeted cancer therapies. Recently, the kinases BRAF and VEGFR-2 have shown synergistic effects on tumor progression. Seeking to develop dual BRAF/VEGFR-2 inhibitors, we synthesized 18 amino-benzothiazole derivatives with structural similarities reported inhibitors. Four compounds-
This research study describes the development of new small molecules based on 2,4-thiazolidinedione (2,4-TZD) and their aldose reductase (AR) inhibitory activities. The synthesis 17 derivatives 2,4-TZDs hybrids was feasible by incorporating two known bioactive scaffolds, benzothiazole heterocycle, nitro phenacyl moiety. most active hybrid (8b) found to inhibit AR in a non-competitive manner (0.16 µM), as confirmed kinetic studies molecular docking simulations. Furthermore, vivo experiments...
In response to the urgent need for continuous discovery of new anti-proliferative agents, a series quinazoline compounds
Abstract New pyrazoles have been synthesized and evaluated as breast cancer cell growth inhibitors. Condensation of the substituted pyrazole-4-carbaldehyde 1 with acetophenone chloroacetophenone afforded α, β-unsaturated ketones 2 3 , respectively. Compounds were subjected to different reactions using hydrazine hydrate, hydroxylamine, o- phenylenediamine, malononitrile under conditions affording 4-substituted pyrazole derivatives 4–28 . Structure elucidation these compounds was conducted IR,...