A5040061549- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Gastrointestinal Tumor Research and Treatment
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Gastrointestinal disorders and treatments
- Ferroptosis and cancer prognosis
- Advanced Proteomics Techniques and Applications
- Esophageal and GI Pathology
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Congenital Diaphragmatic Hernia Studies
- Helicobacter pylori-related gastroenterology studies
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Medical Imaging and Pathology Studies
- Gastroesophageal reflux and treatments
- Cancer-related molecular mechanisms research
- Biomedical Text Mining and Ontologies
Fourth Hospital of Hebei Medical University
2016-2025
Hebei Medical University
2010-2024
Abstract Background The increasing incidence of early-stage T1 gastric cancer (GC) underscores the need for accurate preoperative risk stratification lymph node metastasis (LNM). Current pathological assessments often misclassify patients, leading to unnecessary radical surgeries. Methods Through analysis transcriptomic data from public databases and GC tissues, we identified a 4-mRNA panel (SDS, TESMIN, NEB, GRB14). We developed validated Risk Stratification Assessment (RSA) model combining...
BACKGROUND Adenocarcinoma of the esophagogastric junction (AEG) has distinct malignant features compared with other esophageal and gastric cancers. Its management is controversial largely influenced by tumor location involvement. Hence, understanding clinicopathological characteristics prognosis AEG essential for optimizing treatment strategies. AIM To evaluate patients AEG, providing insights METHODS This retrospective study analyzed cases admitted between January 2016 December 2017....
Emerging evidence has revealed the significant roles of nicotinamide n-methyltransferase (NNMT) in cancer initiation, development, and progression; however, a pan-cancer analysis NNMT not been conducted. In this study, we first thoroughly investigated expression prognostic significance relationship between tumor microenvironment using bioinformatic analysis. was significantly increased associated with poor prognosis many common cancers. correlated infiltration levels cancer-associated...
The detection rate of colorectal neuroendocrine tumours (CR-NETs) is increasing, but their treatment still controversial. Lymph node metastasis an important reference index for the selection treatment. aim our study was to investigate factors associated with lymph and prognosis CR-NETs.The case characteristics patients from January 2011 December 2020 were retrospectively analysed, including age, gender, tumour size, location, metastasis, pathological grade follow-up.A total 195 cases CR-NETs...
Previous studies have identified useful endoscopic ultrasonography (EUS) features to predict the malignant potential of gastrointestinal stromal tumors (GISTs). However, results were not consistent. Artificial intelligence (AI) has shown promising in medicine.
BACKGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors, including gastric cancer (GC), and is associated with tumor progression immune infiltration; however, the roles mechanisms epithelial-mesenchymal transition (EMT) GC are unknown. AIM To investigate role mechanism progression, invasion, migration. METHODS In this study, relationship between GC, as well possible network regulatory CALD1, was investigated by bioinformatics validated experiments....
Yi Lu, Jiachuan Wu, Minhui Hu, Qinghua Zhong, Limian Er, Huihui Shi, Weihui Cheng, Ke Chen, Yuan Liu, Bingfeng Qiu, Qiancheng Xu, Guangshun Lai, Yufeng Wang, Yuxuan Luo, Jinbao Mu, Wenjie Zhang, Min Zhi, and Jiachen Sun. Gut Liver -0001;0:. https://doi.org/10.5009/gnl220347
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are relatively rare tumors that arise from the diffuse system, and biggest advances in molecular biology have helped understanding these biological diversity of over past decades. It is important to determine carcinogenesis GEP-NEN perspective genetic backgrounds.Mitochondrial DNA (mtDNA) peripheral blood 66 patients 75 healthy controls without history any cancer were examined for single nucleotide polymorphisms (SNPs) mutations...
Abstract Background The aim of this study is to evaluate and compare the safety efficacy endoscopic mucosal resection with a cap (EMR-c) those submucosal dissection (ESD) for rectal neuroendocrine tumors (R-NETs) ≤ 15 mm in diameter, analyze risk factors incomplete resection. Methods A total 122 patients who underwent EMR-c or ESD R-NETs at Fourth Hospital Hebei Medical University between February 2007 December 2020 were invovled study. clinical outcomes two groups compared evaluated....
The aim of the present study was to investigate expression and clinical significance oncofetal protein insulin-like growth factor (IGF) II mRNA-binding 3 (IMP3) in differentiation gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN). A total 162 patients who were diagnosed with GEP-NEN, underwent surgical or endoscopic resection from January 2006 March 2013, enrolled study, including 85 cases grade (G)1 tumors, 40 G2 28 G3 carcinomas 9 mixed stage adenoneuroendocrine carcinomas....
Gastroesophageal junction adenocarcinoma (GEJA) is a malignant tumor located at the of esophagus and stomach, incidence which increasing year by year, while screening for early biomarkers limited. Tandem mass tagging (TMT) coupled with liquid chromatography-tandem spectrometry (LC/MS/MS) has been used to screen differential proteins in various cancers.Differential GEJA precancerous lesions were screened using TMT-LC/MS/MS, then that met expectations selected trend clustering analysis,...
<title>Abstract</title> Background Currently, numerous studies focus on the analysis of risk factors for lymph node metastasis in early gastric cancer, but few analyze drainage patterns metastatic nodes. Methods Data was retrospectively analyzed from a database cancer resections 2014–2018. The cohort included 786 pT1 patients with complete data. Outcomes evaluated were frequencies, survival analyses, and impacting prognosis. Results overall rate 23.7%. 5-year (54.8% vs 95.7%; P < 0.001)...
Objective: To investigate the association between promoter region-938 polymorphism of B-cell lymphoma/leukemia-2 (Bcl-2) gene and esophageal cancer (EC) gastric cardia adenocarcinoma (GCA) in Hebei Province. Methods: From 2007 to 2010, 145 patients 169 cardiaccancer patientsfrom outpatient department Fourth Hospital Medical Universitywereselected a case group, 195 non-tumor were selected control group during same period. A questionnaire survey was used collect information research subjects....
Gastric duplication cysts are very rare disease that mainly diagnosed by endoscopic ultrasonographic fine-needle aspiration biopsy. In the past, this was usually treated with traditional surgery and rarely minimally invasive surgery. However, therapy has many advantages, such as no skin wound, organ preservation, postoperative pain reduction, early food intake, fewer complications, shorter post-procedure hospitalization.We report a case of ultrasonography-guided (EUS-FNA) combined...
Objective: Biological behavior, pathological characteristics and prognostic factors of 355 cases with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) were analyzed in this retrospective study. Methods: In our study, patients pathologically diagnosed as GEP-NENs identified from April 2006 to November 2017 the Fourth Hospital Hebei Medical University. The biological prognosis retrospectively. Results: There (228 males 127 females) a mean age 58.3±10.7 years. detected most frequently...
To discuss the epidemic strength of cardia and distant stomach cancers in high risk region esophageal cancer along south Taihang mountain such as Shexian, Linxian, Cixian Counties, to clarify tasks for control upper gastrointestinal tract a whole region. Comparisons incidence mortality rates esophageal, were made between Cixian, Linxian Shexian Counties with reference detection situ precancerous lesions three by endoscopic screening. The screening was performed from 1999 through 2004...
Endoscopic diagnosis of early-stage primary esophageal small cell carcinoma: Report two cases