A5102854899- Bipolar Disorder and Treatment
- Cancer Immunotherapy and Biomarkers
- Advances in Oncology and Radiotherapy
- Head and Neck Cancer Studies
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- Diversity and Career in Medicine
- Inflammatory mediators and NSAID effects
- Cancer Diagnosis and Treatment
- Circadian rhythm and melatonin
- Radiopharmaceutical Chemistry and Applications
- Genetics and Neurodevelopmental Disorders
- Proteoglycans and glycosaminoglycans research
- Osteoarthritis Treatment and Mechanisms
- Immunotherapy and Immune Responses
- Oral Health Pathology and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Treatments and Mutations
- Genetic Syndromes and Imprinting
- Monoclonal and Polyclonal Antibodies Research
- Migraine and Headache Studies
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2023
Leitat Technological Center
2022
Sociedade Portuguesa de Cardiologia
2017
Portuguese League Against Epilepsy
2017
University of Cagliari
2011-2015
Colorectal cancer (CRC) remains a major global health concern, partly due to resistance therapy and the lack of new effective treatments for advanced disease. The combination 5-Fluorouracil (5FU, thymidylate synthase inhibitor) irinotecan (a topoisomerase 1 is widely used in first-line subsequent treatments. This study aims identify novel therapeutic targets enhance combinatorial therapy, improving treatment efficacy durability response. We performed loss-of-function screen using HT29 CRC...
Specific serum biomarkers of cartilage metabolism such as oligomeric matrix protein (sCOMP) and procollagen type II C-terminal propeptide (sPIICP) well hyaluronan (sHA), a biomarker synovitis, have been implicated in the pathophysiology knee osteoarthritis (OA). However, associations these with severity disease OA risk factors, including age obesity remain inconclusive. This analysis examines between radiographic pain, wells obesity, gender participants, other factors.
Bipolar disorder (BD) is a highly heterogeneous and heritable psychiatric illness. Age at onset has been shown to be powerful tool for dissecting both the phenotypic genetic complexity of BD. In this article, we present findings from an association study between DRD2 TaqIA polymorphism age onset, showing that alleles genotypes locus associate with early
Approximately 20% of lung adenocarcinomas harbor activating mutations at KRAS, an oncogene with the ability to alter tumor immune microenvironment. In this retrospective study, we examined 103 patients KRAS-mutant adenocarcinoma who were treated immunotherapy-based regimens and evaluated clinical outcomes according PD-L1 expression type KRAS mutation. Among all included, 47% carried G12C mutation whereas 53% harbored non-G12C mutations. status was available for 77% cases, higher among tumors...
e13039 Background: Oral and pharyngeal cancer is the 11th most common malignancy worldwide. Although oral cavity a potentially accessible site for examination, up to 50% of cancers are detected at advanced stage. The Mobile Unit Stomatology Dental Medicine (UMEMD) Portuguese League Against Cancer (LPCC) Association Hospital (APMDH) has developed early diagnosis consultations. This consultations were performed by team 50 doctors specialized in diagnosis. Once month UMEMD went different region...