A5070411081- Bariatric Surgery and Outcomes
- Esophageal and GI Pathology
- Hernia repair and management
- Diet and metabolism studies
- Tuberous Sclerosis Complex Research
- Gastroesophageal reflux and treatments
- Advanced Glycation End Products research
- Gastric Cancer Management and Outcomes
- Stoma care and complications
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition and Health in Aging
- Microtubule and mitosis dynamics
- Dysphagia Assessment and Management
- Gastrointestinal disorders and treatments
- Body Contouring and Surgery
- Polyomavirus and related diseases
- Pancreatic and Hepatic Oncology Research
- Foreign Body Medical Cases
- Genetic and Kidney Cyst Diseases
- Retinoids in leukemia and cellular processes
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Actinomycetales infections and treatment
- Intestinal and Peritoneal Adhesions
Universidade do Porto
2025
Centro Hospitalar de Entre o Douro e Vouga E.P.E.
2016-2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2023
Hospital de São Sebastião
2023
Hospital da Luz
2023
University of Coimbra
2013-2022
Champalimaud Foundation
2021-2022
Brigham and Women's Hospital
2014-2017
Harvard University
1992-2017
Consejo Superior de Investigaciones Científicas
2008
We report here that disruption of a recently discovered kinesin-like protein in Drosophila melanogaster, KLP61F, results mitotic mutation lethal to the organism. show absence KLP61F function, spindle poles fail separate, resulting formation monopolar spindles. The phenotype metaphase arrest with polyploid cells is reminiscent seen fungal bimC and cut7 mutations, where it has also been shown pole bodies are not segregated. specifically expressed proliferating tissues during embryonic larval...
Adiponectin, the most abundant peptide secreted by adipocytes, is involved in regulation of energy metabolism and vascular physiology. Here, we have investigated effects exogenous administration adiponectin on metabolism, reactivity perivascular adipose tissue (PVAT) mesenteric arteries Wistar rats fed a high-fat diet.The NO-dependent independent vasorelaxation were isolated from 12-month-old male (W12m) diet (HFD) for 4 months compared with those age-matched given control diet. Adiponectin...
p62/sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate that accumulates in cells with hyperactive mTORC1, such as kidney mutations the tumor suppressor genes tuberous sclerosis complex (TSC)1 or TSC2. Here we report p62 critical mediator of TSC2-driven tumorigenesis, Tsc2
ABSTRACT Canine transmissible venereal tumour (CTVT) is a common diagnosis in many low‐income countries, and managing its chemoresistant cases can be challenging within the conventional vincristine sulfate chemotherapy protocol. Also, predictive markers of chemoresistance for this remain unidentified. This study aimed to evaluate CTVT cytological characteristics develop scoring system resistance. For purpose, 40 were retrospectively analysed based on their clinical aspects response...
In this study we investigate pyridoxamine (PM) and/or sulforaphane (SFN) as therapeutic interventions to determine whether activators of NFE2-related factor 2 (Nrf2) can be used in addition with inhibitors advanced glycation end products (AGE) formation attenuate oxidative stress and improve endothelial dysfunction type diabetes. Goto-kakizaki (GK) rats, an animal model non-obese diabetes, were treated or without PM SFN during 8 weeks compared age-matched Wistar rats. At the treatment,...
ABSTRACT Background: Bariatric surgery is performed all over the world with close to 500.000 procedures per year. The most techniques are Roux-en-Y gastric bypass and sleeve gastrectomy. Despite this data, effective procedure, biliopancreatic diversion or without duodenal switch, represents only no more than 1.5% of procedures. Technical complexity, morbidity, mortality, severe nutritional adverse effects related procedure main fears that prevent universal acceptance. Aim: To explain...
Single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) is a restrictive/hypoabsorptive procedure recommended for patients obesity class 3. For safety reasons, SADI-S can be split into two-step by performing (SG) first. This stepwise approach also provides an unprecedented opportunity to disentangle the weight loss mechanisms triggered each component. The objective was compare trajectories and post-prandial endocrine metabolic responses of 3 submitted or SG as first step SADI-S.
The 205-kD microtubule-associated protein (205K MAP) is one of the principal MAPs in Drosophila. 205K MAP similar to HeLa 210K/MAP4 family since it shares following biochemical properties: present several isoforms, has a molecular mass approximately 200 kD, and thermostable. Furthermore, immuno-crossreactivity been observed between mouse MAP4, 210K, Drosophila MAP. Currently, there little information concerning biological function this group nonmotor MAPs. We have used classical genetic...
The success of a bioartificial pancreas crucially depends on ameliorating encapsulated beta cells survival and function. By mimicking the cellular in vivo niche, aim this study was to develop novel model for encapsulation capable establishing an appropriate microenvironment that supports interactions between extracellular matrix (ECM) components.ECM components (Arg-Gly-Asp, abbreviated as RGD) were chemically incorporated alginate hydrogels (alginate-RGD). After encapsulation, INS-1E outcome...
Obesity is associated with complex adipose tissue energy metabolism remodeling. Whether AT metabolic reprogramming differs according to body mass index (BMI) and across different obesity classes unknown. This study’s purpose was evaluate compare bioenergetics substrate preference of visceral (VAT) pertaining individuals class 2 3. VAT obtained from patients (n = 15) 7; BMI 37.53 ± 0.58 kg/m2) or 3 8; 47.79 1.52 used assess oxygen consumption rate (OCR) mitochondrial preferences. presented...
Cinnamaldehyde (CN) is an activator of NF-E2-related factor 2 (Nrf2), which has the potential to reduce endothelial dysfunction, oxidative stress and inflammation in metabolic disorders. Our main purpose was evaluate effects CN on vascular dysfunction syndrome rats. Normal Wistar (W) rats were divided into eight groups: (1) rats; (2) W fed with a high-fat diet (WHFD); (3) sucrose (WS); (4) WHFD (WHFDS); (5) treated (WCn); (6) WS (WSCn); (7) (WHFDCn); (8) WHFDS (WHFDSCn). treatment 20...
Abstract Background Parastomal hernia (PH) is a common complication post stoma creation, often coexisting with incisional hernias. Stoma closure the primary treatment for PH, options including simultaneous repair (stoma and abdominal wall reconstruction – AWR) or deferred two-stage approach. The optimal approach remains undetermined. study aimed to assess outcomes following AWR in both approaches, focusing on complications recurrence. Method Four cases were presented, two undergoing...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Vascular risk factors are associated with a higher incidence of dementia. In fact, diabetes mellitus is considered main factor for Alzheimer's disease (AD) and both diseases characterized by vascular dysfunction. However, the underlying me
Gastric volvulus is a rare but potentially life-threatening condition, with difficult diagnosis. We present case report of demented woman aged 65 years that attended the emergency department epigastric pain and vomiting for past 10 days. The chest plain revealed retrocardiac air-filled mass abdomino-pelvic computed tomography confirmed diagnosis gastric volvulus. patient was admitted. A nasogastric tube introduced, antibiotics parenteric nutrition were started didn't eat anything. operated...