A5077079807- Pain Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
- Plant Pathogens and Fungal Diseases
- Cardiac Ischemia and Reperfusion
- Botulinum Toxin and Related Neurological Disorders
- Cancer Treatment and Pharmacology
- Glycogen Storage Diseases and Myoclonus
- Metabolism, Diabetes, and Cancer
- Mast cells and histamine
- Edible Oils Quality and Analysis
- Asthma and respiratory diseases
- Plant-based Medicinal Research
- Natural product bioactivities and synthesis
- Pharmacological Receptor Mechanisms and Effects
- Pharmacology and Obesity Treatment
- Immune Response and Inflammation
- Advancements in Transdermal Drug Delivery
- Traditional and Medicinal Uses of Annonaceae
- Neuroscience and Neuropharmacology Research
- Antimicrobial Peptides and Activities
- Phytochemical Studies and Bioactivities
- Drug-Induced Adverse Reactions
- Phytochemistry and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
- Curcumin's Biomedical Applications
Universidade Federal de Minas Gerais
2017-2024
Federal University of São João del-Rei
2014-2019
Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity FAMEs mainly against Paracoccidioides spp., as well testing interaction these compounds with commercial drugs also their antioxidant potential. presented small IC50 values (1.86-9.42 μg/mL). All three tested showed isolates spp. MIC ranging 15.6-500 µg/mL. Sunflower exhibited that extended to other genera, an 15.6 μg/mL Candida...
Metformin, an AMP-activated protein kinase (AMPK) activator, is oral hypoglycemic drug widely used to treat patients with type 2 diabetes. As AMPK plays a role in the nociceptive processing, investigating effects induced by metformin experimental models of pain warranted. In present study, we further evaluated and neuropathic investigated mechanisms that could mediate such effects. Metformin was administered per os (p.o.) mice. Nociceptive response heat (hot-plate) mechanical allodynia...
Ethanol extract and fractions obtained from aerial parts of Smilax campestris were examined in order to determine their phenolic composition, antioxidant capacity antifungal activities. High-performance liquid chromatography coupled with DAD analysis indicated that quercetin rutin the main compounds present butanol fraction ethanol extract, respectively. The activity assessed by scavenging ability on 1,1-diphenyl-2-picrylhydrazyl radical was significantly more pronounced for than commercial...
The gasotransmitter hydrogen sulfide (H2S) is known to regulate many pathophysiological processes. Preclinical assays have demonstrated that H2S donors exhibit anti-inflammatory and antinociceptive activities, characterized by reduction of inflammatory mediators production, leukocytes recruitment, edema mechanical allodynia. In the present study, effects induced 4-methylbenzenecarbothioamide (4-MBC) in models pain inflammation mice, mechanisms mediating such H2S-releasing property this...