A5055420770- Malaria Research and Control
- Parasitic Diseases Research and Treatment
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Parasites and Host Interactions
- Bacterial Infections and Vaccines
- Hepatitis Viruses Studies and Epidemiology
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Insects and Parasite Interactions
- Hepatitis B Virus Studies
- Helminth infection and control
- Parasite Biology and Host Interactions
- Hemoglobinopathies and Related Disorders
- Leprosy Research and Treatment
- Pneumonia and Respiratory Infections
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Drug Transport and Resistance Mechanisms
- Food Safety and Hygiene
- Travel-related health issues
- Monoclonal and Polyclonal Antibodies Research
- Tuberculosis Research and Epidemiology
- Data-Driven Disease Surveillance
- Vaccine Coverage and Hesitancy
Bundeswehrkrankenhaus
2024
Hôpital d'Instruction des Armées Bégin
1994-2012
HIA du Val-de-Grâce à Paris
2006-2012
Santé Publique France
2012
Institut Pasteur
2002-2010
Institut Pasteur de la Guyane
2010
Departamento de Epidemiología
2006
Institut Pasteur de Dakar
1998-2005
Institut de Médecine Tropicale du Service de Santé des Armées
1990-2005
Institut Louis Malardé
1991-1994
An influenza survey was conducted in seven sentinel sites Dakar, Senegal from June 1996 to December 1998. Throat or nasal swab cultures were randomly collected 804 patients suffering influenza-like symptoms. Influenza viruses isolated at a similar proportion adults and children (P = 0.29). Strains of B sporadic cases 1997, whereas type A virus associated with an peak. Proportions isolation varied 17.5% 40.0% between 1998 during the peak period (July/September) acute respiratory infection...
The in-vitro activities of pyronaridine, amodiaquine, chloroquine and quinine were evaluated against 161 isolates Plasmodium falciparum from Senegal (Dielmo, Ndiop Pikine), using an isotopic, micro, drug susceptibility test. mean IC50 values (50% inhibitory concentration) for pyronaridine amodiaquine 3.8 nM (95% confidence interval CI), 3.1-4.4) 12.0 CI, 10.0-14.0 nM), respectively. Pyronaridine more active than susceptible parasites. However, both drugs significantly less (P < 0.002 P...
Journal Article Similar feeding preferences of Anopheles gambiae and A. arabiensis in Senegal Get access M. Diatta, Diatta aLaboratoire de Zoologie Médicale, Institut Français Recherche Scientifique pour le Développement en Coopération (ORSTOM), Pasteur, B.P 1386, Dakar, Sénégal Search for other works by this author on: Oxford Academic PubMed Google Scholar Spiegel, Spiegel bInstitut B.P. 220, L. Lochouarn, Lochouarn D. Fontenille ∗ ∗Address correspondence: Didier Fontenille, orstom-Institut...
The in vitro activities of doxycycline, chloroquine, quinine, amodiaquine, artemether, pyrimethamine, and cycloguanil were evaluated against Plasmodium falciparum isolates from Senegal (Dielmo Ndiop), using an isotopic, micro, drug susceptibility test. 71-50% inhibitory concentration (IC50) values for doxycycline ranged 0.7 to 108.0 microM the geometric mean IC50 71 was 11.3 (95% confidence interval = 9.5-13.4 microM). activity did not differ significantly (P 0.0858) between...
The in vitro activities of ferrochloroquine, chloroquine, quinine, mefloquine, halofantrine, amodiaquine, artesunate, atovaquone, cycloguanil and pyrimethamine were evaluated against Plasmodium falciparum isolates from Senegal (Dielmo, Ndiop), using an isotopic micro-drug susceptibility test. IC50 values for ferrochloroquine ranged 0.55 to 28.2 nM the geometric mean 55 was 7.9 (95% CI, 6.5-9.7 nM). Ferrochloroquine 35 times more active than chloroquine (35-fold greater chloroquine-resistant...
ABSTRACT Reverse transcriptase PCR (RT-PCR) for diagnosis of Rift Valley fever (RVF) was evaluated by using 293 human and animal sera sampled during an RVF outbreak in Mauritania 1998. Results the RT-PCR diagnostic method were compared with those virus isolation (VI) detection immunoglobulin M (IgM) antibodies. Our results showed that is a specific, sensitive tool early phase disease its do not differ significantly from obtained VI. Moreover, combined IgM antibody 100% concordance
In April 1991 supervised mass prophylaxis of lymphatic filariasis with a single dose ivermectin, 100 μg/kg, was carried out in Polynesian village high infection rate Wuchereria bancrofti humans and active transmission by the vector mosquito, Aedes polynesiensis. Of 876 inhabitants aged 3 years or more (pregnant women excluded), 864 (98·6%) were treated. Simultaneously, venous blood samples collected from 577 (97·5%) 595 15 more, whom 122 (21·4%) found to be microfilaria (mf) carriers (86...
Pregnancy is associated with a greater susceptibility to Plasmodium falciparum infections, which may result in serious complications affecting both the mother and fetus. To compare allelic diversity multiplicity of infection same women during outside pregnancy, we conducted retrospective analysis monthly fingerprick blood samples collected longitudinal survey Ndiop, Senegalese village mesoendemic malaria. Merozoite surface protein-1 (msp1) block 2 merozoite protein-2 (msp2) genotypes were...
Abstract Purpose In many countries, outpatient and inpatient care are separated. During hospitalization, therefore, switching the medication to of hospital formulary is required. Methods We newly designed a algorithm in six steps (S0–S5) conducted study at Bundeswehr Hospital Hamburg (300 beds, 80% civilians). performed (i) reconciliation obtain information on medications (ii) review solve drug-related-problems, e.g., drug-drug interactions. applied (iii) switch formulary. Results identified...
French military personnel are subject to a compulsory vaccination schedule. The aim of this study was describe vaccine adverse events (VAE) reported from 2002 2010 in armed forces. VAE routinely surveyed by the Centre for epidemiology and public health. For each case, practitioners fill notification form, providing patient characteristics, clinical information vaccines administered. study, following influenza A(H1N1)pdm09 were excluded. Among 473 cases retained, 442 (93%) corresponded...
The recombinant R23, PfEB200, and GST-5 antigens derive from conserved associated with the Plasmodium falciparum-infected erythrocyte membrane. They were identified as targets of protective antibodies in Saimiri sciureus model. We have assessed here humoral response to these humans. Cross-sectional surveys conducted two Senegalese villages different levels endemicity. prevalence specific IgG IgM was similar influenced by age both localities. anti-R23 decreased after rainy season,...
Journal Article Wuchereria bancrofti infection in human and mosquito populations of a Polynesian village ten years after interruption mass chemoprophylaxis with diethylcarbamazine Get access J.-L. Cartel, Cartel Institut Territorial de Recherches Medicales Louis Malardé, B.P. 30, Papeete, Tahiti, Polynésie Française French Polynesia Search for other works by this author on: Oxford Academic PubMed Google Scholar N.L. Nguyen, Nguyen A. Spiegel, Spiegel J.-P. Moulia-Pelat, Moulia-Pelat R....
Abstract: Many genes have been implicated in the risk of severe malaria, generally based on candidate gene studies case/control populations. Among these genes, there has conflicting reports for implication a variant intercellular adhesion molecule 1 (ICAM1), ICAM1 Kilifi , while vitro provided independent support functional role this variant. In order to explore possible susceptibility/resistance malaria and try understand its clinical relevance disease process, we conducted linkage...
To investigate the relationship between entomologic inoculation rate (EIR) and time to reappearance of malaria parasites after radical treatment under moderate seasonal transmission conditions, a study was undertaken in mesoendemic area Senegal where is concentrated over an annual three-month period averages 12 infective bites per person year. A three-day course quinine administered 48 asymptomatic adults 19 66 years age. Malaria parasitemia were monitored every week for two months cases...
In the Armed Forces, knowledge about causes of deaths is required in order to develop prevention strategies. This study presents main characteristics among male active-duty personnel French Forces during 2006–10 period and compares them with general population. The data are provided by military public health surveillance. Comparisons specific mortality rates (MR) were performed using a Poisson regression. Standardized ratios (SMRs) calculated compare There 1455 [MR: 100.9 per 100 000...