A5100677807- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Hemoglobinopathies and Related Disorders
- Retinal Diseases and Treatments
- Cancer Diagnosis and Treatment
- Epilepsy research and treatment
- Cardiac Arrest and Resuscitation
- Pediatric Pain Management Techniques
- Iron Metabolism and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Glaucoma and retinal disorders
- Galectins and Cancer Biology
- Retinal Imaging and Analysis
- Alzheimer's disease research and treatments
- Fetal and Pediatric Neurological Disorders
- Testicular diseases and treatments
- Macrophage Migration Inhibitory Factor
- Signaling Pathways in Disease
- Teratomas and Epidermoid Cysts
- Head and Neck Anomalies
- Pancreatitis Pathology and Treatment
- Genetic and Kidney Cyst Diseases
- Parathyroid Disorders and Treatments
Centro Hospitalar de Lisboa Ocidental
2024
Universidade do Porto
2017-2024
Rede de Química e Tecnologia
2024
Hospitais da Universidade de Coimbra
2024
Centro Hospitalar de Lisboa Central
2010-2024
Universidade Nova de Lisboa
2023
King's College London
2021-2023
Instituto Português de Oncologia Francisco Gentil
2023
Unidade Hospitalar de Bragança
2020-2022
Hospital de São Bernardo
2021
Pain is a persistent symptom of Rheumatoid Arthritis, and the K/BxN serum transfer model recapitulates both association dissociation between pain joint inflammation in RA. Furthermore, this features monocyte/macrophage infiltration joints lumbar dorsal root ganglia (DRG), where these immune cells are close to nociceptive neurons. We focussed on CX3CR1-monocyte/macrophage trafficking show that at peak paw swelling associated with nociception, CX3CR1 deletion altered neither nor macrophage...
Neuropathic pain remains poorly managed by current therapies, highlighting the need to improve our knowledge of chronic mechanisms. In neuropathic models, dorsal root ganglia (DRG) nociceptive neurons transfer miR-21 packaged in extracellular vesicles macrophages that promote a proinflammatory phenotype and contribute allodynia. Here we show conditional deletion DRG was coupled with lack upregulation chemokine CCL2 after nerve injury reduced accumulation CCR2-expressing macrophages, which...
Effective reepithelialization after injury is essential for correct wound healing. The upregulation of keratinocyte α3β1 integrin during suggests that this adhesion molecule involved in healing; however, its precise role process unknown. We have shown here retarded Itga3–/– mouse skin wounds due predominantly to repressed TGF-β1–mediated responses. Specifically, expression the inhibitor TGF-β1–signaling Smad7 was elevated keratinocytes. Indeed, vivo blockade increased rate and WT similar...
We report a female patient with situs inversus, dextrocardia, complex heart malformation, hydrocephalus due to aqueductal stenosis, and abnormal ultrastructure of the respiratory epithelium cilia. Several animal models this disorder implicate ciliary function in genesis hydrocephalus, 11 patients were previously reported syndrome primary dyskinesia. Primary dyskinesia–associated stenosis should be considered as possible cause for fetal or neonatal if heterotaxy, malformations, and/or...
Musculoskeletal chronic pain is prevalent in individuals with Alzheimer's disease (AD); however, it remains largely untreated these patients, raising the possibility that mechanisms are perturbed. Here, we utilise TASTPM transgenic mouse model of AD K/BxN serum transfer inflammatory arthritis. We show male and female WT mice, allodynia associated a distinct spinal cord microglial response characterised by TLR4-driven transcriptional profile upregulation P2Y12. Dorsal horn nociceptive...
Abstract Laminins are expressed highly in blood vessel basement membranes and have been implicated angiogenesis. α6β1‐ α6β4‐integrins major receptors for laminins endothelial cells, but the precise role of α6‐integrin tumour angiogenesis is not clear. We show that vessels human invasive ductal carcinoma breast decreased expression α6‐integrin‐subunit when compared with normal tissue. These data suggest a decrease cells associated To test whether loss subunit affects growth angiogenesis, we...
Introduction: The best route of delivery for the term breech fetus is still controversial. We aim to compare maternal and neonatal outcomes between vaginal cesarean deliveries.Material Methods: Multicentric retrospective cohort study singleton fetuses delivered vaginally or by elective section from January 2012 - October 2014. Primary were morbidity mortality.Results: Sixty five compared 1262 cesarean. Nulliparous women more common in group (69.3% vs 24.6%; p < 0.0001). Gestational age at...
Parathyroid cysts are rare lesions of the cervical region and less frequently mediastinum. They occur mostly in women usually asymptomatic. generally fourth fifth decades life mainly non-functioning. commonly present as a neck mass that is found incidentally during surgery or imaging test. Its importance lies difficulty diagnosis, often confusing itself with thyroid pathology. The diagnosis made intraoperatively, confirmed by histopathological examination. aim this paper to report case...
Paraovarian/paratubal cysts constitute about 10% of adnexal masses and are usually small asymptomatic. A huge paratubal cyst complicated by torsion is a rare cause acute low abdominal pain.We report the case an obese 31-year-old nulliparous woman who presented with large pelvic causing ovarian torsion. The size mass (~25 cm) caused pain, obesity led to explorative laparotomy, which showed central abdominal-pelvic arising from right adnexa. Cystectomy was technically impossible, so all adnexa...
To the editor The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has rapidly become one of biggest health threats world faced. importance controlling disease and its worldwide spread cannot be understated. Vaccination arises as cornerstone this fight against 2019 (COVID-19), though new challenges have emerged with it. Anaphylactic reactions to vaccines are very rare, occurring at a rate 1.31 per million doses administered [1]. Reports on mRNA Pfizer-BioNTech SARS-CoV-2...
Chronic pain is undertreated in people with Alzheimer's disease (AD) and better understanding of the underlying mechanisms chronic this neurodegenerative essential. Neuropathic AD share a significant involvement peripheral immune system. Therefore, we examined development nerve injury-induced allodynia TASTPM (APPsweXPS1.M146V) mice assessed monocytes/macrophages at injury site. developed partial compared to WT days 7, 14 21 after injury, showed complete only treatment naloxone methiodide,...

 Introduction: Rasmussen’s syndrome (RS) is a rare immunomediated disease of childhood-predominant onset, presenting with refractory epilepsy and neurological deficits associated to progressive brain hemiatrophy. Its pathophysiological mechanisms are not well understood, the effect immunotherapy ascertained. Hemispheric surgery an efficacious therapy for epilepsy, despite focal cognitive sequelae. Curative treatment ideal timing still defined. Our study aim describe pediatric...
Invasive lobular carcinoma (ILC) is the second most prevalent form of invasive breast cancer. Characterized by its insidious growth and distinctive histopathological features, ILC often presents with a less predictable metastatic pattern, including potential invasion gastrointestinal tract. This report case patient who developed ileocecal valve metastasis leading to cecal volvulus, rare but critical complication. The slow dissemination delayed diagnosis allowed for significant tumor burden...
Age-related changes in the mitochondrial status of human cumulus cells (hCCs) impact oocyte quality; however, relationship between hCC (dys)function and reproductive aging remains poorly understood. This study aimed to establish interplay dysfunction women’s potential. In this investigation, 266 women were enrolled categorized into two groups based on their age: a young group (<35 years old) an advanced maternal age (AMA) (≥35 old). Comprehensive analysis outcomes was conducted our...
Pleural endometriosis is a rare condition characterized by the presence of endometrial tissue outside uterus, involving pleura. This atypical can be asymptomatic or cause respiratory symptoms such as chest pain, dyspnea, and hemothorax. We present clinical case 32-year-old woman who presented to emergency room with hemothorax due pleural endometriosis.
Objetivos: Comparar mudanças na dor basal do paciente entre os grupos com e sem uso da realidade virtual, antes após a punção venosa avaliar número de tentativas, tempo satisfação virtual. Metodologia: Estudo prospectivo randomizado intervencionista pacientes atendidos em pronto atendimento pediátrico indicação venosa: grupo-intervenção (utilizou virtual no procedimento) grupo- -controle (protocolo hospital, outro método distrativo/analgésico). Comparou-se escala Faces o procedimento,...
Fecal microbiota transplantation (FMT) is indicated in many countries for patients with multiple recurrences of Clostridioides difficile infection (CDI) whom appropriate antibiotic treatments have failed. Donor selection a demanding and rigorous process view the implementation FMT programs worldwide. One most noteworthy factors that has been shown to affect outcomes microbial diversity stool donor. A detailed assessment donor’s crucial, as complex, dynamic, resilient, healthy several...
Abstract Objectives This study assesses the clinical relevance of dipeptidyl peptidase 4 (DPP4) membrane exopeptidase as a biomarker inflammatory bowel disease (IBD). A spike-and-recovery approach DPP4 in fecal samples was used to compare two different methods for protein extraction, followed by stability assessment. Methods Fecal healthy volunteers spiked with known concentrations recombinant were processed using standard manual extraction protocol and CALEX ® protocol. The compared...