A5114375195- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Congenital heart defects research
- Mesenchymal stem cell research
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Muscle Physiology and Disorders
- Ion channel regulation and function
- Neonatal and fetal brain pathology
- Cell Adhesion Molecules Research
- Electrospun Nanofibers in Biomedical Applications
- Ion Channels and Receptors
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- AI in cancer detection
- Advanced Neuroimaging Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Pancreatic function and diabetes
- Osteoarthritis Treatment and Mechanisms
- Apelin-related biomedical research
- Xenotransplantation and immune response
- Telomeres, Telomerase, and Senescence
- Signaling Pathways in Disease
- Cancer Immunotherapy and Biomarkers
- Cellular Mechanics and Interactions
Virbac (France)
2023
Inserm
2014-2021
Centre National de la Recherche Scientifique
2015-2021
Université de Montpellier
2015-2021
Physiologie et Médecine Expérimentale du Coeur et des Muscles
2014-2019
Northeast Ohio Medical University
2012-2013
Cleveland Clinic
2006-2012
Case Western Reserve University
2009-2012
University School
2012
Summa Health System
2012
Abstract MSCs have received attention for their therapeutic potential in a number of disease states, including bone formation, diabetes, stem cell engraftment after marrow transplantation, graft-versus-host disease, and heart failure. Despite this diverse interest, the molecular signals regulating MSC trafficking to sites injury are unclear. known transiently home freshly infarcted myocardium. To identify homing factors, we determined chemokine expression pattern as function time myocardial...
Background— Overexpression of stromal cell-derived factor-1 in injured tissue leads to improved end-organ function. In this study, we quantify the local trophic effects mesenchymal stem cell (MSC) release on MSC engraftment myocardium after acute myocardial infarction. Methods and Results— Conditional cardiac myocyte CXCR4 (CM-CXCR4) null mice were generated by use tamoxifen-inducible cardiac-specific cre crossing floxed with MCM-cre mouse. Studies performed littermates (CM-CXCR4 null) or...
Rationale TRPM4 is a non-selective Ca2+-activated cation channel expressed in the heart, particularly atria or conduction tissue. Mutations Trpm4 gene were recently associated with several human disorders such as Brugada syndrome. has also been implicated at ventricular level, inotropism arrhythmia genesis due to stresses ß-adrenergic stimulation, ischemia-reperfusion, and hypoxia re-oxygenation. However, physiological role of healthy heart remains unclear. Objectives We aimed investigate on...
Background Hepatocyte Growth Factor (HGF) is a pleiotropic cytokine of mesenchymal origin that mediates characteristic array biological activities including cell proliferation, survival, motility and morphogenesis. Its high affinity receptor, the tyrosine kinase Met, expressed by wide range tissues can be activated either paracrine or autocrine stimulation. Adult myogenic precursor cells, so called satellite express both HGF Met. Following muscle injury, HGF-Met stimulation plays key role in...
Myocardial remodeling is a major contributor in the development of heart failure (HF) after myocardial infarction (MI). Integrin-linked kinase (ILK), LIM-only adaptor PINCH-1, and α-parvin are essential components focal adhesions (FAs), which highly expressed heart. ILK binds tightly to PINCH-1 α-parvin, regulates FA assembly promotes cell survival via activation Akt. Mice lacking ILK, PINCH or have been shown develop severe defects heart, suggesting that these proteins play critical role...
Methaemo- globinaemia is an unusual but readily treatable cause of unexpected cyanosis and collapse Oxidation the iron in haemoglobin from ferrous to ferric state yields methaemoglobin, which does not carry oxygen imparts a chocolate hue blood. The diagnosis should be suspected when blood sample brown coloured redden on exposure air. Blood concentrations methaemoglobin do normally exceed 2%. aetiology methaemoglobinaemia may congenital due deficiency cytochrome b 5 reductase structural...
Stage specific embryonic antigen 1+ (SSEA1+) cells have been described as the most primitive mesenchymal progenitor cell in bone marrow. Cardiac injury mobilizes SSEA1+ into peripheral blood but their vivo function has not characterized.We generated animals with chimeric marrow to determine fate and of response acute cardiac pressure overload.Lethally irradiated mice were transplanted normal where wild-type replaced green fluorescent protein (GFP) cells. was induced by trans-aortic...
Endogenous progenitor cells may participate in cardiac repair after a myocardial infarction (MI). The beta 2 adrenergic receptor (ß2-AR) pathway induces proliferation of c-kit+ (CPC) vitro. We investigated if ß2-AR pharmacological stimulation could ameliorate endogenous CPC-mediated regeneration MI. C-kit+ CPC ß1-AR and expression was evaluated vivo A significant increase the percentage CPCs expressing measured 7 days post-MI. Accordingly, 24 hrs low serum hypoxia vitro significantly...
Abstract Previous work has demonstrated both that there are substantial individual differences in the rate of physiological development, and infants with risk factors for Sudden Infant Death Syndrome (SIDS) develop more slowly, suggesting their increased vulnerability may be due to delayed neuronal development associated compromised fetal or early neonatal life. This project aims test hypothesis correlate measurable brain as assessed by magnetic resonance imaging (MRI). Sixty were recruited...
Introduction: Adult stem cell based repair of the heart is due to paracrine factor release. SDF-1 has been shown affect multiple pathways involved in tissue and secreted by mesenchymal cells (MSC). In this study we directly tested importance MSC release on myocardial response engraftment after infarction (MI). Methods: Cardiac myocyte (CM)-CXCR4 null mice were generated using tamoxifen inducible cardiac specific cre crossing CXCR4 floxed with MCM-cre mouse. Studies performed littermates who...
Duchenne muscular dystrophy (DMD) is a devastating condition shortening the lifespan of young men. DMD patients suffer from age-related dilated cardiomyopathy (DCM) that leads to heart failure. Several molecular mechanisms leading cardiomyocyte death in have been described. However, pathological progression DMD-associated DCM remains unclear. In skeletal muscle, dramatic decrease stem cells, so-called satellite has shown patients. Whether similar dysfunction occurs with cardiac muscle...
Abstract Immune checkpoint proteins are important regulators in self-tolerance. However, these same molecules also allow cancer cells to evade immune destruction. Checkpoint inhibitor (CKI) blockade therapies that aim at restoring antitumoral immunity have resulted long-lasting remission patients with cancers were previously seen as incurable. only a fraction of the respond treatments. Research is currently focusing on identifying biomarkers can predict response CKI and stratify patient...