A5016742736- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Heat shock proteins research
- Cell death mechanisms and regulation
- Cardiovascular Issues in Pregnancy
- Neonatal Respiratory Health Research
- Reproductive Health and Contraception
- Atrial Fibrillation Management and Outcomes
- Hemoglobinopathies and Related Disorders
- Melanoma and MAPK Pathways
- Eosinophilic Disorders and Syndromes
- Maternal and fetal healthcare
- Protein Kinase Regulation and GTPase Signaling
- Microbial Metabolism and Applications
- Nutritional Studies and Diet
- Antioxidant Activity and Oxidative Stress
- Central Venous Catheters and Hemodialysis
- Bone health and osteoporosis research
- Pancreatic function and diabetes
- Fatty Acid Research and Health
- Blood properties and coagulation
- Acute Myeloid Leukemia Research
- Kruppel-like factors research
University Hospital of Heraklion
2024
University of Crete
1999-2024
Papageorgiou General Hospital
2008-2022
Southampton General Hospital
2013-2017
University of Southampton
2012-2017
Cancer Research UK
2013-2017
Athens State University
2014
Senologic Hellenic Society
2014
Innsbruck Medical University
2013
Universität Innsbruck
2013
To elucidate the physiological significance of MEK5 in vivo, we have examined effect mek5 gene elimination mice. Heterozygous mice appear to be healthy and were fertile. However, mek5−/− embryos die at approximately embryonic day 10.5 (E10.5). The phenotype includes abnormal cardiac development as well a marked decrease proliferation an increase apoptosis heart, head, dorsal regions mutant embryos. absence does not affect cell cycle progression but sensitizes mouse fibroblasts (MEFs) ability...
The signaling mechanism by which JNK affects mitochondria is critical to initiate apoptosis. Here we show that the absence of provides a partial resistance toxic effect heavy metal cadmium. Both wild type and jnk −/− fibroblasts undergoing death exhibit cytosolic cytochrome c but, unlike cells, JNK‐deficient do not display increased caspase activity DNA fragmentation. apoptotic correlates with specific defect in activation Bax. We conclude JNK‐dependent regulation Bax essential mediate...
Protein-protein interactions mediated through the C-terminal Bcl-2-associated athanogene (BAG) domain of BAG-1 are critical for cell survival and proliferation. Thioflavin S (NSC71948)-a mixture compounds resulting from methylation sulfonation primulin base-has been shown to dose-dependently inhibit interaction between Hsc70 in vitro. In human breast cancer lines, with high expression levels, reduces binding Hsc70, Hsp70, or CRAF decreases proliferation viability. Here, we report development...
Primary eosinophlia associated with the FIP1L1-PDGFRA rearrangement represents a subset of chronic eosinophilic leukaemia (CEL) and affected patients are very sensitive to imatinib treatment. This study was undertaken in order examine prevalence clinicopathologic genetic features cohort 15 adult presenting profound eosinophilia (> 1.5 x 109/L).Reverse transcriptase-polymerase chain reaction (RT-PCR) used for detection results confirmed by direct sequencing. C-KIT-D816V mutation analysed...
// Emmanouil Papadakis 1 , Natalia Robson Alison Yeomans Sarah Bailey Stephanie Laversin Stephen Beers A. Emre Sayan Margaret Ashton-Key 1, 2 Stefan Schwaiger 3 Hermann Stuppner Jakob Troppmair 4 Graham Packham Ramsey Cutress Cancer Research UK Centre Sciences Unit, Southampton General Hospital, Southampton, United Kingdom University Hospital of Faculty Medicine, Institute Pharmacy/Pharmacognosy, Center Molecular Biosciences, Innsbruck, Austria Daniel Swarovski Laboratory, Department...
Abstract Introduction and objectives Thoracic ultrasound (TUS) has been established as a powerful diagnostic monitoring tool in the Intensive Care Unit (ICU). However, studies outside critical care setting are scarce. The aim of this study was to investigate value TUS for hospitalized or ambulatory community patients. Materials methods This retrospective conducted from 2016 2020 clinic at Heraklion University Hospital. examination performed using standard machine (EUB HITACHI 8500),...
Abstract Background During pregnancy and puerperium women are at high VTE risk. Current guidelines recommend dynamic VTE-risk assessment during pregnancy. Based on related RCOG-guidelines we constructed a digital tool: PATrisks ( www.PATrisks.com ). Using this tool, retrospectively evaluated the thrombotic risk in 742 from our previous work, who received thromboprophylaxis based clinical experience for A) complications, B) IVF treatment C) prothrombotic tendency, order to investigate whether...
Abstract BCL-2-associated athanogene-1 (BAG-1) is expressed by osteoblast-lineage cells; early embryonic lethality in Bag-1 null mice, however, has limited the investigation of BAG-1 function osteoblast development. In present study, bone morphogenetic protein-2/BMP-2-directed osteogenic differentiation marrow stromal cells (BMSCs) +/− (heterozygous) female mice was decreased significantly. Genes crucial for differentiation, matrix formation and mineralisation were at significantly lower...
Objective: To estimate markers of prothrombotic state and endothelial dysfunction in youths with type 1 diabetes mellitus (T1DM) investigate possible associations anthropometric/demographic data, glycaemic control lipid profile. Methods: In a cross-sectional design, we recruited 155 T1DM determined levels plasminogen activator inhibitor-1-antigen (PAI-1-Ag), von Willebrand factor-antigen (vWF-Ag), fibrinogen (FB), lipids glycosylated haemoglobin (HbA 1c ). Results: Of all the participants,...
Abstract Introduction The aim of our study was to establish reference ranges for neonatal coagulation and fibrinolysis parameters investigate their relationship with gestational age (GA) birth weight (BW). Methods A single‐centre prospective conducted in all healthy neonates born hospital during the period, excluding those maternal or disorders diseases that affect haemostasis. following were measured: fibrinogen, prothrombin time (PT), international normalized ratio (INR), activated partial...