A5032430447- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intensive Care Unit Cognitive Disorders
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Cardiac Arrest and Resuscitation
- Mesenchymal stem cell research
- Sarcoidosis and Beryllium Toxicity Research
- Sepsis Diagnosis and Treatment
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Hematological disorders and diagnostics
- Infectious Diseases and Tuberculosis
- Lipid metabolism and disorders
- Pleural and Pulmonary Diseases
- Immune responses and vaccinations
- Inflammation biomarkers and pathways
- Parvovirus B19 Infection Studies
- Leptospirosis research and findings
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
University Hospital of Heraklion
2013-2024
University of Crete
2010-2024
Royal Brompton Hospital
2023
Asthma in older adults affects quality of life and results a higher hospitalization rate mortality. In common clinical practice, asthma the elderly is underdiagnosed undertreated or overdiagnosed mistreated. The age-related reduction perception shortness breath high incidence comorbidities make diagnosis management more difficult challenging for physicians. Chronic obstructive pulmonary disease (COPD) usually easy to distinguish from asthma, but sometimes distinction late-onset patients,...
Mesenchymal stem (stromal) cells (MSCs) are multipotent stromal that have the ability to modulate immune response tissue injury and promote repair in vivo. The therapeutic potential of ex vivo expanded MSCs currently under investigation for a variety chronic acute lung diseases. This review summarizes encouraging results regarding safety administration from recent current clinical trials idiopathic pulmonary fibrosis, respiratory distress syndrome, obstructive disease. It also reviews early...
During passive mechanical ventilation, the driving pressure of respiratory system is an important mediator ventilator-induced lung injury. Monitoring during assisted similar to controlled could be a tool identify patients at risk The aim this study was describe over time and whether when high occurs in critically ill ventilation.Sixty-two fulfilling criteria for ventilation were prospectively studied. Patients included treating physician selected proportional assist (PAV+), mode that...
Idiopathic Pulmonary Fibrosis and Rheumatoid Arthritis associated usual interstitial pneumonia seem to have the same poor outcome as there is not an effective treatment. The aim of study explore reparative ability bone marrow mesenchymal stem cells by evaluating system telomerase/telomeres propose a novel therapeutic approach. BM-MSCs were studied in 6 IPF patients, 7 patients with RA-UIP healthy controls. We evaluated telomere length well mRNA expression both components telomerase (human...
We have previously shown a different local and systemic angiogenic profile of CXC chemokines in Idiopathic Pulmonary Fibrosis (IPF) patients compared to sarcoidosis. In particular, sarcoidosis showed an angiostatic microenvironment, as with the cytokine milieu seen IPF. Purpose Study. Our aim was further investigate aforementioned finding by measuring expression granulomatous fibrotic diseases. estimated levels vascular endothelial growth factor (VEGF) its high-affinity receptor, Flt-1...
Defective tissue repair and remodeling are main aspects of Chronic Obstructive Pulmonary Disease (COPD) pathophysiology. Bone marrow mesenchymal stem cells (BM-MSCs) have been implicated in this direction, as their functional impairment recruitment could possibly contribute to disease development progression. The present study characterizes for the first time expression migration related chemokine receptors ligands BM-MSCs from COPD patients. CXCR4/SDF1a CCR7/CCL19-CCL21 mRNA levels were...
Background Overnight desaturation predicts poor prognosis across interstitial lung diseases (ILDs). The aim of the present study was to investigate whether nocturnal is associated with pulmonary vasculopathy and mortality. Methods A retrospective single centre 397 new ILD patients carried out including idiopathic fibrosis (IPF) (n=107) non-IPF fibrotic (n=290). This largest date effect significant (SND) (≥10% total sleep time oxygen saturation ≤90% measured by pulse oximetry). Results...
Abstract Introduction and objectives Thoracic ultrasound (TUS) has been established as a powerful diagnostic monitoring tool in the Intensive Care Unit (ICU). However, studies outside critical care setting are scarce. The aim of this study was to investigate value TUS for hospitalized or ambulatory community patients. Materials methods This retrospective conducted from 2016 2020 clinic at Heraklion University Hospital. examination performed using standard machine (EUB HITACHI 8500),...
Leptospirosis is a reemerging zooanthroponosis with worldwide distribution, though it has higher incidence in areas tropical climate. A characteristic finding of the disease its wide spectrum symptoms and organ involvement, as can appear either very mild flu-like manifestations or multiorgan failure, affecting central nervous system (CNS) concomitant hepatorenal dysfunction (Weil’s syndrome) significant high mortality rate. We report herein fatal case 25 years old female, previously healthy,...
Sarcoidosis is a multi-systemic disorder of unknown origin and most commonly affects the lungs. Diagnosis relies on presence non-caseating granulomas histologic specimens. In high-resolution computed tomography, characteristic findings are peribronchovascular thickening, perilymphatic nodular distribution, bilateral hilar adenopathy. Confluent opacities or large masses rare manifestations disease. It well recognized that sarcoidosis can mimic infectious, malignant, granulomatous conditions....
It has been suggested that stromal cell-derived factor-1alpha ((SDF-1alpha) or CXCL12, both transcripts, TR1 and TR2) its cognate receptor CXCR4 may regulate cancer metastasis. We have investigated the role of vascular endothelial growth factor (VEGF), angiopoietins (Ang-1 Ang-2) biological axis CXCL12-CXCR4, in patients with malignant pleural effusions (PEs).Twenty five patients, seven transudative PEs due to heart failure 18 exudative (7 small cell lung (SCLC) 11 nonsmall (NSCLC)) were...
Percutaneous central venous catheterization, although a widely used technique in ICU patients worldwide, is not devoid of complications even under real-time ultrasound guidance. Arterial puncture well-recognized complication, while unintended subclavian or carotid artery cannulations during attempted catheterization are infrequent, but documented with potentially deleterious consequences. Recently, endovascular balloon tamponade has emerged as the preferred initial approach to repair...
Intravesical Bacillus Calmette-Guérin (BCG) instillation is the most effective adjuvant therapy for superficial urinary bladder carcinoma, prolonging disease-free survival. Although it usually well tolerated, moderate to severe local or systemic infectious complications, including sepsis involving multiple organs, may occur.We report unusual case of a man in his mid '70s who presented with septic shock and acute respiratory failure requiring intubation. Lack response antibiotics, history...
The ventilatory ratio (VR) is a simple index of efficiency and dead space. Because increased space high demands impose limitation to unassisted ventilation, may predispose patients injurious strong efforts during assisted evaluation the VR could provide helpful information weaning. We hypothesize that there threshold associated with tolerance breathing.In retrospective analysis, we included subjects ventilated in control mode for at least 24 h, who were successfully liberated from mechanical...
Post-traumatic cerebral venous sinus thrombosis (ptCVST) often remains underdiagnosed due to the non-specific nature of clinical signs, commonly mimicking severe traumatic brain injury (TBI) manifestations. Early recognition this rare and potentially life-threatening complication is crucial for effective management TBI patients in Intensive Care. The present study reports case a 66-year-old male who was transferred emergency department moderate TBI. Initial computed tomography (CT) scans...
<h3>BACKGROUND:</h3> The present study aimed to validate a recently proposed algorithm for assistance titration during proportional assist ventilation with load-adjustable gain factors, based on noninvasive estimation of maximum inspiratory pressure (peak P<sub>mus</sub>) and effort (pressure-time product [PTP] peak P<sub>mus</sub>). <h3>METHODS:</h3> Retrospective analysis the recordings obtained from 26 subjects ventilated factors under different conditions, each considered as an...