A5101779335- Sulfur Compounds in Biology
- Nutrition, Genetics, and Disease
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Amino Acid Enzymes and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Clinical Nutrition and Gastroenterology
Hebei Medical University
2023
Abstract The present study aimed to investigate the effects of lipopolysaccharide (LPS) stimulation on oxidative damage, apoptosis, and glutamine (Gln) transporter Alanine-Serine-Cysteine 2 (ASCT2) expression in porcine small intestinal epithelial cells (IPEC-J2), preliminarily elucidated relationship between ASCT2 level damage apoptosis IPEC-J2 cells. were treated without (control group, CON, N = 6) or with 1 μg/mL LPS (LPS LPS, 6). Cell viability, lactate dehydrogenase (LDH) content,...
Parthenolide (PA) shows promising therapeutic effect on ulcerative colitis and colorectal cancer, can ameliorate colon inflammation in a gut microbiota-dependent manner. In the present study, an effective UHPLC-QTOF-MS method aided by rat intestinal microbiota biotransformation was applied to characterize 34 metabolites (including series of characteristic R-Sn-R type organosulfur compounds) PA for first time. Noteworthy, PA-S2-PA PA-S3-PA could react with cysteine generate H2S via...