A5072240801- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Glioma Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactive Compounds
- Synthesis and Biological Activity
- Radiomics and Machine Learning in Medical Imaging
- Natural product bioactivities and synthesis
- Identification and Quantification in Food
- Cancer, Hypoxia, and Metabolism
- Antimicrobial Peptides and Activities
- Insect symbiosis and bacterial influences
- Entomopathogenic Microorganisms in Pest Control
- Medical and Biological Ozone Research
- Bacteriophages and microbial interactions
- Yersinia bacterium, plague, ectoparasites research
- Bacterial Genetics and Biotechnology
- Fungal Biology and Applications
- Brain Metastases and Treatment
- Probiotics and Fermented Foods
- RNA and protein synthesis mechanisms
- Insect and Pesticide Research
- Zoonotic diseases and public health
University of Giessen
2017-2024
German Center for Infection Research
2022
Fraunhofer Institute for Molecular Biology and Applied Ecology
2019-2022
PT Bio Farma (Indonesia)
2020
University of Bonn
2017
Therapeutic options to combat Gram-negative bacterial pathogens are dwindling with increasing antibiotic resistance. This study presents a proof of concept for the heterologous-expression approach expand on novel class darobactins and generate analogs different activities pharmacokinetic properties.
Tunicates (Ascidians, sea squirts) are marine protochordates, which live sedentary or sessile in colonial solitary forms. These invertebrates have to protect themselves against predators and invaders. A most successful strategy, not being eaten by prevent pathogenic microorganisms settle, is the usage of chemical molecules for defence. To accomplish this, tunicates take advantage specialized metabolites produced bacteria associated with them. Therefore, microbiome can be regarded as a...
Sponges are a well-known bioresource for bioactive compounds. In this study, antibacterial activity-guided fractionation of the extract from an Indonesian marine Dactylospongia elegans sponge led to discovery four merosesquiterpenoids, namely, new sesquiterpenoid aminoquinone nakijiquinone V (1), along with illimaquinone (2), smenospongine (3), and dyctioceratine C (4). The structure compound 1 was elucidated by 1D 2D NMR as well LC-HRESIMS data analysis. Compounds 2–4 showed moderate low...
Abstract Increasing numbers of multi-drug resistant pathogens call for new chemical scaffolds, addressing novel targets, that can serve as lead structures the development life-saving drugs. For antibiotics, natural product-inspired molecules represent a most promising resource. Natural products evolved to high complexity and occupy space different than synthetic libraries. However, clinical translation is often impeded by their relative inaccessibility medicinal chemistry optimization, e.g....
Introduction: the objective was to evaluate impact of IDH1 R132H mutation, MGMT methylation and PD-L1 expression in high grade glioma that received standard therapy (surgery, radiation chemotherapy) overall survival (OS).