A5032940870- Intracerebral and Subarachnoid Hemorrhage Research
- Glioma Diagnosis and Treatment
- Stress Responses and Cortisol
- Hormonal and reproductive studies
- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Alzheimer's disease research and treatments
- Cerebrospinal fluid and hydrocephalus
- AI in cancer detection
- Pituitary Gland Disorders and Treatments
- Acute Ischemic Stroke Management
- Global Health and Surgery
- Breast Lesions and Carcinomas
- Vascular Malformations Diagnosis and Treatment
- Menopause: Health Impacts and Treatments
- melanin and skin pigmentation
- Ear Surgery and Otitis Media
- Cancer Genomics and Diagnostics
- Long-Term Effects of COVID-19
- Chemokine receptors and signaling
- Cancer therapeutics and mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Hypothalamic control of reproductive hormones
- Cancer Immunotherapy and Biomarkers
- Bone Tumor Diagnosis and Treatments
Pelita Harapan University
2016-2025
Padjadjaran University
2024
National University of Singapore
2024
Siloam Eye Hospital
2009-2021
Universitas Muhammadiyah Tangerang
2021
Edith Cowan University
2008-2018
The University of Western Australia
2015
Reduction in testosterone levels men during aging is associated with cognitive decline and risk of dementia. Animal studies have shown benefits for supplementation improving cognition reducing Alzheimer's disease pathology. In a randomized, placebo-controlled, crossover study subjective memory complaint low levels, we investigated whether treatment significantly improved performance on various measures functioning. Forty-four were administered battery neuropsychological tests to establish...
Glioblastoma multiforme (GBM) is a very aggressive type of primary brain tumor in adults with poor prognosis. DNA double‑strand breaks are known to be associated the development numerous cancer types due their ability generate genomic instabilities. In GBM, phosphatidylinositol 3‑kinase (PI3K)/Akt pathway common that can activated by exogenous and endogenous factors. Genomic instability may an stimulating factor for activation PI3K/Akt pathway, which inhibit apoptosis GBM cells. Spontaneous...
Severe global shortages in neurosurgery, surgery, and healthcare general have been documented, especially low- middle-income countries (LMICs).In LMICs, how do we expand both neurosurgery overall healthcare?Two different approaches to improving are presented. Author EW convinced a private hospital chain that neurosurgical resources were important throughout Indonesia. TK established consortium (Alliance Healthcare) obtain financial support for Peshawar, Pakistan.The expansion over 20 years...
Testosterone replacement therapy (TRT) has been investigated in older men as a preventative treatment against Alzheimer's disease and dementia. However, previous studies have contradictory. We assessed TRT physiological effects 44 (aged 61 ± 7.7 years) with subjective memory complaints using double blind, randomized, crossover, placebo-controlled study. Participants were randomized into 2 groups, one group received transdermal testosterone (50 mg) daily for 24 weeks, followed by 4 week...
The effect of testosterone on the levels Alzheimer's disease amyloid-β peptide (Aβ) was investigated in guinea pigs. Castrated pigs (GPX) were administered at two different dosages, following which plasma and cerebrospinal
<i>Background/Aims:</i> Luteinizing hormone (LH) has been shown to alter the metabolism of beta amyloid (Aβ), a key protein in Alzheimer’s disease (AD) pathogenesis. While LH and components required for receptor signalling are present brain, their role CNS remains unclear. In vitro, facilitate neurosteroid production Aβ metabolism. However, whether can directly modulate cerebral levels vivo not previously studied. this study, we investigated effect chronic administration guinea...
BackgroundThis study aimed to investigate whether the addition of candesartan standard care regimen improved outcome in patients with coronavirus 2019 (COVID-19).MethodsA prospective non-randomized open-label was undertaken from May August 2020 on 75 subjects (aged 18–70 years) hospitalized Siloam Kelapa Dua Hospital. Uni- and multi-variable Cox regression analyses were performed obtain hazard ratios (HRs). The primary outcomes were: (1) length hospital stay; (2) time negative swab; (3)...
BACKGROUND: In searching for the best source of stem cells, researcher found adipose cells as one ideal due to its easiness in harvesting and potential differentiating into other cell lineage.METHODS: We isolated from tissue, cultured confirmed immunophenotype using polymerase chain reaction.RESULTS: Cluster differentiation (CD)44, CD73, CD90, CD105 were expressed, which represent mesenchymal cells. CONCLUSION: Mesenchymal can be tissue. KEYWORDS: adipose, isolation,
Angiomatoid fibrous histiocytoma (AFH) is an uncommon soft tissue neoplasm that can exhibit diverse morphological features, including myxoid change. Rarely, the tumor occurs intracranially and poses considerable diagnostic challenges to neuropathologists. This compounded by a recently coined entity, referred as intracranial mesenchymal (IMMT). These tumors show significant overlaps with AFH from clinicopathological molecular genetic viewpoints. We described unusual in 30-year-old man. The...
Background There has been increasing number of babies detected with SIH. In regard to find diagnostic clues for the first-rate who really needs CT scan and referral, simple observation look at certain clinical laboratory findings is needed. Objective To identify associated spontaneous intracranial hemorrhage (SIH) in babies. Methods Retrospective was carried out among ba- bies SIH within last two a half years. Patients were excluded if there an obvious cause such as trauma or any underlying...
Ependymomas are glial neoplasms with a wide morphological spectrum. The majority of supratentorial ependymomas known to harbor ZFTA fusions, most commonly RELA. We present an unusual case 9-year-old boy ependymoma harboring noncanonical ZFTA-MAML2 fusion. This had histomorphological features lacking typical findings and bearing resemblance primitive neoplasm focal, previously undescribed myogenic differentiation. discuss the diagnostic pitfalls in this briefly review histological gene...
Background: The intracerebral hemorrhage (ICH) score is the most common prognosticator for ICH patients; nevertheless, specific regional epidemiological characteristics might affect its reliability. This study aims to evaluate original application in Indonesian then, assess possible modifications make it more applicable.Methods: from every patient admitted a tertiary center Indonesia was assessed. Based on mean age of patients and life expectancy, threshold modified 59 years; statistical...
The use of digital online teaching media in improving the surgical skills medical students is indispensable, yet it still not widely explored objectively. first-person-view method may be more effective as provides realism to clerkship achieving basic skills.