A5091233760- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Animal Behavior and Reproduction
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Nicotinic Acetylcholine Receptors Study
- IL-33, ST2, and ILC Pathways
- Viral Infectious Diseases and Gene Expression in Insects
- Biofuel production and bioconversion
- Metabolomics and Mass Spectrometry Studies
- Stress Responses and Cortisol
- Genetic diversity and population structure
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Microbial Metabolic Engineering and Bioproduction
- Neonatal Respiratory Health Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neurogenesis and neuroplasticity mechanisms
- Insect and Arachnid Ecology and Behavior
- Carcinogens and Genotoxicity Assessment
- Extracellular vesicles in disease
- Physiological and biochemical adaptations
- Circular RNAs in diseases
- MicroRNA in disease regulation
Translational Genomics Research Institute
2023-2025
Arizona State University
2015-2024
Bhabha Atomic Research Centre
2012
Reptiles exhibit a variety of modes sex determination, including both temperature-dependent and genetic mechanisms. Among those species with chromosomes varying heterogamety (XX/XY ZZ/ZW) have been observed different degrees differentiation. Karyotype studies demonstrated that Gila monsters (Heloderma suspectum) ZZ/ZW determination this system is likely homologous to the in Komodo dragon (Varanus komodoensis), but little else known about their chromosomes. Here, we report assembly analysis...
Abstract Large-scale changes in the structure and cellular makeup of distal lung are a hallmark pulmonary fibrosis (PF), but spatial contexts that contribute to disease pathogenesis have remained uncertain. Using image-based transcriptomics, we analyzed gene expression 1.6 million cells from 35 unique lungs. Through complementary cell-based innovative cell-agnostic analyses, characterized localization PF-emergent cell types, established molecular basis classical PF histopathologic features...
Image-based spatial transcriptomics deliver gene expression measurements of RNA transcripts in tissue slices with single-molecule resolution and context preserved. Modern Graph Neural Network (GNN) models are promising methods for capturing the complex molecular cellular phenotypes tissues at single-transcript single-cell levels. A key application GNNs is detection domains or niches, that is, groups molecules and/or cells collaboratively work together to produce phenotypes. Due vast number...
Abstract Environmental enrichment (EE) is a robust intervention for reducing cocaine-seeking behaviors in animals when given during forced abstinence. However, the mechanisms that underlie these effects are not well-established. We investigated adult male rat transcriptome using RNA-sequencing (RNA-seq) following differential housing abstinence from cocaine self-administration either 1 or 21 days. Enriched, 21-day rats displayed significant reduction behavior compared to housed isolation....
Abstract The human lung is structurally complex, with a diversity of specialized epithelial, stromal and immune cells playing specific functional roles in anatomically distinct locations, large-scale changes the structure cellular makeup this distal hallmark pulmonary fibrosis (PF) other progressive chronic diseases. Single-cell transcriptomic studies have revealed numerous disease-emergent/enriched cell types/states PF lungs, but spatial contexts wherein these contribute to disease...
Abstract Individual behavioral variation is ubiquitous across taxa and important to understand if we wish fully use data the ecology evolution of organisms. Only recently have studies individual in dispersal behavior become a focus research. A better understanding likely improve our population dynamics. In particular, dynamics critically small populations (endangered species) large (pest may be driven by unique variants. Here documented ballooning Western black widow spiderlings Latrodectus...
The dopamine D3 receptor is a prime target for developing treatments cocaine use disorders (CUDs). In this study, we conducted pre-clinical investigation of the therapeutic potential long-acting, partial agonist, MC-25-41. Male rats were pre-treated with MC-25-41 (vehicle, 1.0, 3.0, 5.6, or 10 mg/kg, intraperitoneal (IP)) five minutes prior to tests sucrose intake on either progressive ratio schedule reinforcement variable interval 60 s multiple consisting 4, 15-min components available in...
The RNA-binding protein HuD (a.k.a., ELAVL4) is involved in neuronal development and synaptic plasticity mechanisms, including addiction-related processes such as cocaine conditioned-place preference (CPP) food reward. most studied function of this mRNA stabilization; however, we have recently shown that also regulates the levels circular RNAs (circRNAs) neurons. To examine role control coding non-coding RNA networks associated with substance use, identified sets differentially expressed...
Reptiles exhibit a variety of modes sex determination, including both temperature-dependent and genetic mechanisms. Among those species with chromosomes varying heterogamety (XX/XY ZZ/ZW) have been observed different degrees differentiation. Karyotype studies demonstrated that Gila monsters (
Abstract RNA-sequencing (RNA-seq) technology has led to a surge of neuroscience research using animal models probe the complex molecular mechanisms underlying brain function and behavior, including substance use disorders (SUDs). However, findings from rodent studies often fail be translated into clinical treatments. Here, we developed novel pipeline for narrowing candidate genes preclinical by translational potential demonstrated utility this model in three RNA-seq self-administration. This...
RNA-sequencing (RNA-seq) technology has led to a surge of neuroscience research using animal models probe the complex molecular mechanisms underlying brain function and behavior, including substance use disorders. However, findings from rodent studies often fail be translated into clinical treatments. Here, we developed novel pipeline for narrowing candidate genes preclinical by translational potential demonstrated its utility in 2 RNA-seq self-administration. This uses evolutionary...
Abstract The addiction field relies heavily on rodent models to probe the complex molecular mechanisms underlying drug motivation and reward. However, findings in animal research often fail be reproduced or translated into clinical treatments. Here, we developed applied standardized workflows three RNA-sequencing (RNA-seq) studies self-administration assess reproducibility translational viability of potential gene targets. Generally, found low overlap differentially-expressed genes (DEGs)...