Abstract Background Optimal anti-bacterial activity of meropenem requires maintenance its plasma concentration (Cp) above the minimum inhibitory (MIC) pathogen for at least 40% dosing interval (fT > MIC 40). We aimed to determine whether a 3-h extended infusion (EI) achieves fT 40 on first and third days therapy in patients with severe sepsis or septic shock. also simulated performance EI respect other pharmacokinetic (PK) targets such as 4 × 40, = 100, 100. Methods Arterial blood samples...

Withaferin-A (WA) is the principle component of Withania somnifera (Ashwagandha). It has several biological activities including anti-cancer, anti-diabetic, neuroprotective, hepatoprotective and immune-modulatory properties. The acute sub-acute toxicity oral WA was investigated in mice. In study, up to 2000 mg/kg well tolerated without any signs or death. mice were orally administered 10, 70 500 respectively, daily for 28 days. Upon physiological, serum chemistry, hematology histopathogical...

Background: Thyroid diseases and Diabetes Mellitus are the two most common endocrine disorders encountered in clinical practice. have been shown to mutually influence each other an association between both conditions has reported literature. This study aims estimate prevalence of dysfunction among patients with TYPE-II correlation HbA1C levels TSH levels. Methods: 55 Patients coming history type 2 or without hypothyroidism more than 3 years duration on treatment for diabetes mellitus...

The applications and scope of digitization technology in dentistry are becoming increasingly valuable right from clinical to research, student training, teaching, laboratory techniques. Mastering 3D printing its usage essential for dental practitioners technicians as it allows them choose necessarily know what is offered, well how implement everyday practices thereby contributing the betterment profession. study aims assess practitioners' technicians' knowledge, understanding, related use...

ABSTRACT Pulp stones are nodular, calcified masses commonly appearing in the coronal pulp and occasionally extending radicular pulp. Retrieval of remains a challenge for endodontist as complete cleaning shaping root canal system is bases successful endodontic therapy. The aim this case report to show retrieval long measuring 14 9.5 mm by utilizing synergistic effect ultrasonics sodium hypochlorite from palatal roots maxillary molars. Such has not been reported literature so far. How cite...

The current work was aimed to develop Medium Chain Triglyceride (MCT) rich self nanoemulsifying preconcentrate of paclitaxel (PTX) for parenteral delivery. Very high concentrations Cremophor EL and ethanol in Taxol have rendered patients severe side effects. Years extensive research on development cost effective safer vehicle PTX, failed provide a promising replacement Taxol. MCT selected as oil owing its acceptability, solubilization capacity multiple therapeutic benefits cancer cachexia....

Aim: To evaluate the potential of iron nanoparticles (FeNPs) in conjunction with magnetic fields (MFs) to enhance osteoblast cytomechanics, promote cell homing, bone development activity, and antibacterial capabilities, assess their vivo angiogenic viability using chicken egg chorioallantoic membrane (CAM) model. Settings Design: Experimental study conducted a laboratory setting investigate effects FeNPs MFs on cells angiogenesis custom titanium (Ti) substrate coated FeNPs. Materials...

Stenson's duct of parotid gland is a major which drains saliva into the oral cavity. Deep penetrating wound in form cut or crush injury to buccal area carries risk injury. It ductal exposure, laceration, total severing, crushing duct. These conditions are difficult diagnose because complex anatomy and variable nature Successful management depends on early diagnosis appropriate intervention, failing may lead complications like sialocele salivary fistula. Many techniques have been proposed for...

Chikungunya fever occurred in an epidemic form the state of Maharashtra after a gap about 32 years. Many cases with symptoms which were suggestive reported from village Kasegaon, Dist Sangli, Maharashtra, India. Hence, this study was done to assess magnitude outbreak and identify possible socio-environmental factors are responsible for fever.This cross sectional carried out at Kasegaon by team Krishna Institute Medical Sciences, Karad, collaboration Primary Health Centre, Distt. Sangli.The...

Intrinsic discoloration of a non-vital permanent incisor tooth due to trauma may have significant esthetic and social impact on children adolescents. Treatment options for discolored Non-vital teeth are bleaching, crowns or veneers. However, this restorative crown veneer approach has drawback being an invasive technique. Intervention should be minimal destruction structure not compromise future options. The advantage bleaching over is that it offers simple conservative in removal stain...

Introduction: Currently, digital dentistry is an umbrella topic that predominantly includes the areas of intraoral scanning, 3D printing and Computer Aided Designing/Computer Manufacturing (CAD/CAM). It allows transfer information between physical data, with significant advantage easing transition process increasing efficiency. Digital technology a crucial component modern which has influence on our present future dental practice. Aim: To assess knowledge, awareness practices use its...

ABSTRACT Background Wearing a dental prosthesis is known to increase oral candidal colonization and predispose the wearer candidosis. Denture wearers frequently use fingers take out of their mouth. Oral Candida , if present may contaminate wearer's finger. The objective this study was investigate simultaneous cavity fingertips complete denture wearers. Materials methods A total 25 apparently healthy male subjects who had worn dentures for at least 1 year were selected. Information about each...

With the use of CAD/CAM technology and rapid prototyping, opportunities for digitisation are unlimited. 3D printing is going to revolutionise traditional teaching laboratory methods with progress new materials, machines. Given large number options available, one must keep up current emerging in order make benefit same. The aim study assess dental technicians' knowledge, understanding practices related dentistry India.From November 2021 January 2022, a cross-sectional questionnaire-based was...

Aim: To develop a sensitive HPLC method for the quantitation of sunitinib (SU) and its active metabolite N-desethyl-sunitinib (SU12662) in human plasma. Materials & methods: The analytes were extracted from 500 μl plasma using liquid-liquid extraction followed by protein precipitation. Chromatographic separation two internal standard, vandetenib, was achieved on hydrophilic interaction liquid chromatography analytical column gradient program. Calibration curves linear over range 10-250 ng/ml...

Gemination and fusion are morphological dental anomalies, characterized by the formation of a clinically wide tooth. occurs when one tooth bud tries to divide, while if two buds unite. The terms double teeth, formation, conjoined geminifusion, vicinifusion twinning often used describe gemination. Double teeth associated with clinical problems such as poor esthetics, spacing caries susceptibility. Management cases requires comprehensive knowledge entity well it. This report presents case...