A5043941946- Bone and Joint Diseases
- Bone health and treatments
- Autopsy Techniques and Outcomes
- Hip disorders and treatments
- Injury Epidemiology and Prevention
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Autoimmune and Inflammatory Disorders Research
- Forensic Entomology and Diptera Studies
- Forensic Anthropology and Bioarchaeology Studies
- Biochemical effects in animals
- Traumatic Ocular and Foreign Body Injuries
- Alcohol Consumption and Health Effects
- Ion Transport and Channel Regulation
- Pain Mechanisms and Treatments
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Automotive and Human Injury Biomechanics
- Traumatic Brain Injury and Neurovascular Disturbances
- Restraint-Related Deaths
- Renal function and acid-base balance
- Paleopathology and ancient diseases
- Radiation Dose and Imaging
- Lower Extremity Biomechanics and Pathologies
Sapporo Medical University
2010-2020
Cardiovascular Center Hokkaido Ohno Hospital
2020
Sapporo University
2011
Ministry of Law and Justice
2011
Objectives. Osteonecrosis of the femoral head is observed in patients treated with steroids. However, pathogenesis osteonecrosis remains unclear. We established a rat model by injecting lipopolysaccharide (LPS) and steroid, assessed consequences this on histology, systemic immune response lipid synthesis.
Summary Alcohol‐induced osteonecrosis of the femoral head ( ONFH ) is observed in alcohol abusers and patients with alcoholic fatty liver disease. It has been reported that Toll‐like receptor 4 TLR 4) signalling plays a crucial role pathogenesis We previously corticosteroid‐induced rat model, suggested contributes to . Thus, it thought alcohol‐induced probably similar The aim this study was develop new animal model for evaluate relationship between pro‐inflammatory response via TLRs...
Postmortem CT (PMCT) is increasingly used in forensic practice, and knowledge classification of typical postmortem imaging findings would facilitate the interpretation PMCT. The goal this study was to define time-related course chest findings. Twelve cadavers (eight male, four female, 27-81 [mean, 60.0]years) were examined twice by PMCT within an interval time (4-164 h 30.8; median, 17.5]). pleural-space-fluid volume, pulmonary parenchyma decreased aerated lung volume (DLV), %DLV...
ABSTRACT We have recently demonstrated that pathological changes leading to increased bone resorption by osteoclast activation are related the induction of pain‐like behavior in ovariectomized (OVX) mice. In addition, bisphosphonate and antagonist transient receptor potential vanilloid type 1 (TRPV1), an acid‐sensing nociceptor, improved threshold value behaviors accompanying improvement acidic environment tissue based on inactivation. The aim this study was evaluate effect (i) inhibitor...
Summary The hip joint is one of the major structures in human body and resultant force acting through 300% weight. Therefore, weight bearing, as a cause ischaemia, may contribute to development non‐traumatic osteonecrosis femoral head ( ONFH ). However, it remains unclear whether bearing related . Therefore aim this study was clarify role Non‐weight‐bearing NWB ) rats were tail suspended prevent any coming bear on hindlimbs from day 1 time sacrifice. weight‐bearing WB group also housed...
Non-traumatic osteonecrosis of the femoral head (ONFH) often occurs after corticosteroid therapy in patients with inflammatory diseases. Recent studies suggest that toll-like receptor (TLR) signaling may contribute to pathogenesis diseases, and reason for diseases is related anti-inflammatory activities corticosteroids through reduction NF-κB. We hypothesized administration TLR ligands combination causes ONFH transcription factors ONFH. The aim study was evaluate (1) incidence rats TLR7 or...
We previously reported that a toll-like receptor 4 signaling contributes to the development of osteonecrosis femoral head. Also, oxidative stress is suggested be one possible pathogenesis A recent study showed leads stress. The aim present was evaluate whether stimulation and subsequent corticosteroid treatment lead head in rat, associated with it. Male Wistar rats were randomly divided into four groups: Saline + Saline, Methylprednisolone, Lipopolysaccharide Methylprednisolone....
Alcohol consumption prior to traumatic brain injury (TBI) promotes morbidity and mortality although the mechanisms involved remain unclear. The caused by TBI, especially contusion, are known be closely associated with edema. Here we examined effects of ethanol pretreatment on edema, inflammatory responses, oxidative stress after contusion. Male Wistar rats were given 3 g/kg intraperitoneally 1 h later subjected ethanol-pretreated group had a significantly decreased survival rate. Magnetic...
Pathological conditions with refractory skeletal pain are often characterized by regional osteoporotic changes such as transient osteoporosis of the hip, migratory osteoporosis, or complex syndrome (CRPS). Our previous study demonstrated that acidic microenvironment created osteoclast activation under high bone turnover induced pain-like behaviors in ovariectomized mice through stimulation acid-sensing nociceptors. The aim present was to examine whether related hind limb using tail-suspended...