Wen‐Hsin Chen

ORCID: 0000-0001-7845-5951
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About
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Research Areas
  • Advanced Polymer Synthesis and Characterization
  • Dendrimers and Hyperbranched Polymers
  • Uterine Myomas and Treatments
  • RNA modifications and cancer
  • Ovarian cancer diagnosis and treatment
  • Circular RNAs in diseases
  • Cytokine Signaling Pathways and Interactions
  • Anorectal Disease Treatments and Outcomes
  • Cardiac Fibrosis and Remodeling
  • Venous Thromboembolism Diagnosis and Management
  • Intraperitoneal and Appendiceal Malignancies
  • Pelvic floor disorders treatments
  • Endometriosis Research and Treatment
  • Hydrogels: synthesis, properties, applications
  • Cancer-related molecular mechanisms research
  • Satellite Communication Systems
  • Preterm Birth and Chorioamnionitis
  • Endometrial and Cervical Cancer Treatments
  • Polydiacetylene-based materials and applications
  • Urinary Bladder and Prostate Research
  • Human Pose and Action Recognition
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Platelet Disorders and Treatments
  • Renal cell carcinoma treatment
  • Gynecological conditions and treatments

Chiayi Chang Gung Memorial Hospital
2022-2025

National Taipei University of Technology
2025

Chang Gung University
2010-2025

Chang Gung Memorial Hospital
2020-2024

Keelung Chang Gung Memorial Hospital
2020-2022

Kaohsiung Chang Gung Memorial Hospital
2020-2021

Abstract Aims Previous studies found a relationship between elevated phenylalanine levels and poor cardiovascular outcomes. Potential strategies are available to manipulate metabolism. This study investigated whether increased predicted mortality in critical patients with either acute heart failure (HF) or on chronic HF, its correlation inflammation immune cytokines. Methods results recruited 152 subjects, including 115 HF admitted for conditions 37 normal controls. We measured left...

10.1002/ehf2.12896 article EN cc-by-nc ESC Heart Failure 2020-07-02

As the LEO satellite industry rapidly expands, demand for remote sensing and telecommunications in marine suburban areas is increasing. Developing higher bandwidth communication interfaces has b ecome a crucial focus space industry. Free optical (FSO) offers bandwidths hundreds of times greater than traditional microwave links, enabling efficient transmission large volumes data. However, current commercial sate llite tracking systems lack high precision needed space-ground laser...

10.1117/12.3042796 article EN 2025-01-10

Vaccination plays an important role during the COVID-19 pandemic. Vaccine-induced thrombotic thrombocytopenia (VITT) is a major adverse effect that could be lethal. For cancer patients, cancer-related thromboembolism another lethal complication. When patients receive their vaccines, following thromboembolic events will more complicated. We presented case recently diagnosed with pancreatic cancer, who had received mRNA-1273 (Moderna) vaccination 12 days prior. Ischemic stroke and VITT were...

10.3389/fmed.2021.772424 article EN cc-by Frontiers in Medicine 2021-11-01

Patients in the intensive care unit (ICU) are at high risk of mortality which is not well predicted. Previous studies noted that leucine has prognostic value a variety diseases. This study investigated whether concentration was useful biomarker metabolic and nutritional status 6-month ICU. We recruited 454 subjects admitted to ICU (348 106 initiation validation cohorts, respectively) with an acute physiology chronic health evaluation (APACHE II) score ≥ 15. measured plasma concentrations,...

10.1155/2022/7389258 article EN cc-by Disease Markers 2022-01-07

Hyperphenylalaninemia predicts poor outcomes in patients with cardiovascular disease. However, the prognostic value and factors associated stress hyperphenylalaninemia (SHP) were unknown critical cardiac ICU.

10.1097/ccm.0000000000005640 article EN cc-by-nc-nd Critical Care Medicine 2022-08-01

Abstract This study synthesizes thermally sensitive block copolymers poly( N ‐isopropylacrylamide)‐ b ‐poly(4‐methyl‐ε‐caprolactone) (PNIPA‐ ‐PMCL) and ‐poly(4‐phenyl‐ε‐caprolactone) ‐PBCL) by ring‐opening polymerization of 4‐methyl‐ε‐caprolactone (MCL) or 4‐phenyl‐ε‐caprolactone (BCL) initiated from hydroxy‐terminated ‐isopropylacrylamide) (PNIPA) as the macroinitiator in presence SnOct 2 catalyst. research prepares a PNIPA bearing single terminal hydroxyl group telomerization using...

10.1002/app.32546 article EN Journal of Applied Polymer Science 2010-06-03

Abstract Aim To evaluate the influence of uterine artery occlusion at myomectomy (UAO + M) on ovarian reserve based serum sex hormone levels, ultrasound and color Doppler examinations. Methods In this cohort study, nine women with symptomatic myomas underwent UAO M were recruited. Each woman was assessed preoperatively 3, 6 months postoperatively, through a serial hormonal, parameters examination for stromal blood flow. The data analyzed using generalized estimating equations. Results There...

10.1111/jog.14236 article EN cc-by-nc Journal of Obstetrics and Gynaecology Research 2020-03-09

Abstract Objectives To evaluate and compare the long‐term clinical outcomes of four different transvaginal mesh systems. Methods This retrospective study included 695 patients classified into groups (Prolift, n = 132; Perigee‐Apogee, 186; Prosima, 60; Elevate; 317), with a median follow‐up time 5.8 years (range 0.5‐12.2 years). The were objective anatomic success (Pelvic Organ Prolapse [POP] Quantification system stage ≤1), exposure, urologic functional assessments. Results For outcomes, we...

10.1111/luts.12408 article EN LUTS Lower Urinary Tract Symptoms 2021-08-18

Abstract Amphiphilic thermally sensitive poly( N ‐isopropylacrylamide)‐ block ‐poly(tetramethylene carbonate) copolymers were synthesized by ring‐opening polymerization of tetramethylene carbonate with hydroxyl‐terminated ‐isopropylacrylamide) (PNiPAAm) as macro‐initiator in the presence stannous octoate catalyst. The synthesis involved PNiPAAm bearing a single terminal hydroxyl group prepared telomerization using 2‐hydroxyethanethiol chain‐transfer agent. characterized 1 H NMR and Fourier...

10.1002/pi.2937 article EN Polymer International 2010-10-15

Abstract This study reports the successful synthesis of amphiphilic MPEG‐ b ‐PCL based‐block copolymers bearing benzyloxy and hydroxyl side groups on PCL block by ring‐opening polymerization 4‐benzyloxy‐ε‐caprolactone (4‐BOCL) ε‐caprolactone (ε‐CL) with methoxy PEG (550 g mol −1 ) as initiator Tin(II) 2‐ethylhexanoate (SnOct 2 catalyst. These were characterized differential scanning calorimetry (DSC), 1 H NMR, gel permeation chromatography. The thermal properties ( T m s) depend polymer...

10.1002/app.36225 article EN Journal of Applied Polymer Science 2012-01-31

To investigate whether the time interval between primary debulking surgery (PDS) and initiating adjuvant chemotherapy affects survival in patients with epithelial ovarian cancer (EOC).We retrospectively reviewed FIGO stage IIB to IV EOC who received PDS followed by our hospital January 2008 December 2016. The optimal cut-off related was determined using Contal O'Quigley method Cox hazard models. regression analysis used identify independent effect of on survival.A total 152 were identified...

10.2147/cmar.s313013 article EN Cancer Management and Research 2021-07-01

Abstract Objective This study aimed to compare the efficacy of anticoagulation therapy and thrombolytic for pulmonary embolism (PE) in patients complicated with shock. Methods retrospective cohort used administrative data from Taiwan's National Health Insurance Research Database. Patients admitted due PE who received inotropic support between January 1, 1997, December 31, 2011, were included. To closely mimic a randomized experiment, thrombolysis plus groups subjected propensity score...

10.1055/s-0040-1713095 article EN Thrombosis and Haemostasis 2020-07-17

<div>Abstract<p>Mesenchymal stem cells (MSC) are strongly associated with tumor progression and have been used as novel cell-based agents to deliver anticancer drugs tumors. However, controversies about the direct involvement of MSCs in suggest that mediate a cancer type-dependent manner. In this report, we analyzed functional interactions between human lung adenocarcinoma (LAC) determine therapeutic potential cancer. We showed effectively inhibited migration, invasion,...

10.1158/0008-5472.c.6504120 preprint EN 2023-03-30

<p>PDF file - 451K, Suppl. Fig. 1 Characterization of BM-MSC surface markers. 2 MSC derived from different donors inhibited LAC cell migration. 3 expresses and secretes OSM. 4 OSM the proliferation CL1-5 A549 cells. 5 migratory capability lung squamous carcinoma. 6 STAT3 did not mediate OSM-dependent inhibition EMT 7 mediated MSC-CM-dependent suppression tumor in vivo. Table List antibodies used report</p>

10.1158/0008-5472.22394775 preprint EN cc-by 2023-03-30
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