A5032666171- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Immune Response and Inflammation
- Pneumonia and Respiratory Infections
- Advanced Glycation End Products research
- Obstructive Sleep Apnea Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nosocomial Infections in ICU
- Neuroscience of respiration and sleep
- Cancer, Hypoxia, and Metabolism
- Congenital Diaphragmatic Hernia Studies
- Palliative Care and End-of-Life Issues
- Glutathione Transferases and Polymorphisms
- Sleep and related disorders
- Metabolomics and Mass Spectrometry Studies
- Antimicrobial Resistance in Staphylococcus
- Pleural and Pulmonary Diseases
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Natural product bioactivities and synthesis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pharmacological Effects of Natural Compounds
- Family and Patient Care in Intensive Care Units
- Genomics, phytochemicals, and oxidative stress
Chang Gung Memorial Hospital
2014-2024
Chang Gung University
2009-2024
Keelung Chang Gung Memorial Hospital
2020-2024
National Taipei University of Technology
2022
Memorial Hospital of South Bend
2020-2022
Mackay Memorial Hospital
2021
Weatherford College
2020
Pulmonary Associates
2016
Abstract Aims Previous studies found a relationship between elevated phenylalanine levels and poor cardiovascular outcomes. Potential strategies are available to manipulate metabolism. This study investigated whether increased predicted mortality in critical patients with either acute heart failure (HF) or on chronic HF, its correlation inflammation immune cytokines. Methods results recruited 152 subjects, including 115 HF admitted for conditions 37 normal controls. We measured left...
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) protects against oxidative stress which is important in the pathogenesis of chronic obstructive pulmonary disease (COPD). Three single nucleotide polymorphisms and 1 triplet repeat polymorphism are found promoter region Nrf2 gene. Molecular haplotyping was performed using DNA obtained from peripheral blood 69 COPD patients. The luciferase activities constructs containing all possible combinations 4 were determined to differ among 16...
Background and objectives: Acute kidney injury (AKI) is common in critically ill patients, especially those with sepsis. Persistently low human leukocyte antigen (HLA)-DR expression monocytes reflects the decreased function of antigen-presenting cells, contributing to poor outcomes This study aimed establish an association between AKI HLA-DR patients Materials Methods: We detected measured plasma levels S100A12, high-mobility group box 1 (HMGB1), advanced glycation end products (AGE),...
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) protects against oxidative stress which is important in the pathogenesis of chronic obstructive pulmonary disease (COPD). Three single nucleotide polymorphisms and 1 triplet repeat polymorphism are found promoter region Nrf2 gene. Molecular haplotyping was performed using DNA obtained from peripheral blood 69 COPD patients. The luciferase activities constructs containing all possible combinations 4 were determined to differ among 16...
Background. The risk factors for Staphylococcus aureus ( S. ) pneumonia are not fully identified. aim of this work was to find out the clinical characteristics associated with infection in patients healthcare-associated (HCAP) and hospital-acquired (HAP), which may be applicable more appropriate selection empiric antibiotic therapy. Methods. From July 2007 June 2010, who were admitted intensive care unit severe HCAP/HAP sepsis enrolled study. Lower respiratory tract sample semiquantitatively...
The BODE index is a multidimensional grading system for predicting the prognoses of patients with chronic obstructive pulmonary disease (COPD). This study investigated whether an amino acids-based metabolic profile developed heart failure (including histidine, ornithine, phenylalanine, and leucine) could identify COPD further discriminates in advanced stages.Ultra-performance liquid chromatography was performed on 119 participants, including 75 at different stages 44 normal controls....
Mechanical ventilation (MV) is required to maintain life for patients with sepsis-related acute lung injury but can cause diaphragmatic myotrauma muscle damage and weakness, known as ventilator-induced diaphragm dysfunction (VIDD). Hypoxia-inducible factor 1α (HIF-1α) plays a crucial role in inducing inflammation apoptosis. Low-molecular-weight heparin (LMWH) was proven have anti-inflammatory properties. However, HIF-1α LMWH affect has not been investigated. We hypothesized that would reduce...
Recent studies have reported that mechanical power (MP) is associated with increased mortality in patients acute respiratory distress syndrome (ARDS). We aimed to investigate the association between 28-day and MP severe pneumonia. In total, data of 313 pneumonia were used for analysis. Serial was calculated daily either 21 days or until ventilator support no longer required. Compared non-ARDS group, ARDS group (106 patients) demonstrated lower age, a higher Acute Physiology Chronic Health...
Patients in the intensive care unit (ICU) are at high risk of mortality which is not well predicted. Previous studies noted that leucine has prognostic value a variety diseases. This study investigated whether concentration was useful biomarker metabolic and nutritional status 6-month ICU. We recruited 454 subjects admitted to ICU (348 106 initiation validation cohorts, respectively) with an acute physiology chronic health evaluation (APACHE II) score ≥ 15. measured plasma concentrations,...
Mechanical ventilation (MV), used in patients with acute lung injury (ALI), induces diaphragmatic myofiber atrophy and contractile inactivity, termed ventilator-induced diaphragm dysfunction. Phosphoinositide 3-kinase- (PI3K-) is crucial modulating fibrogenesis during the reparative phase of ALI; however, mechanisms regulating interactions among MV, fibrosis, PI3K- remain unclear. We hypothesized MV or without bleomycin treatment would increase muscle fibrosis through pathway. Five days...
This prospective randomized trial evaluated the clinical efficacy of inhaled colistin administered through two distinct nebulizer types, a vibrating mesh (VMN) and jet (JN), in treatment ventilator-associated pneumonia caused by multidrug-resistant bacteria. In addition, an vitro model was used to determine optimal delivery colistin.
Background and objective: Cancer cells are larger in size more rigid than blood cells. As the rigidity of contribute to viscosity, an association may exist between high pleural fluid viscosity cancer effusions. The aim this study was determine correlation cell constituents or laboratory data diseases with different aetiologies. Methods: Fluid viscosities were determined effusions obtained via thoracocentesis. Pleural correlated percentages cellular as assessed by cytological examination....
The relationship between serum selenium levels and mortality was investigated in septic patients with severe deficiency (baseline ≤ 80 ng/mL). Eligible of sepsis or shock were randomized to receive Placebo High-Dose Selenium (1,000 μg/day) via intravenous injection. Safety, selenium, mortality, SOFA, Glasgow Coma Scale (GCS) scores monitored. Among all 330 subjects, 27.9% subjects (n=92) had (mean = 66.5 Mortality 27.2%, significantly higher than 17.9% subjects. In group (n=45), 62% showed...
Mechanical ventilation (MV), used in patients with acute lung injury (ALI), induces diaphragmatic myofiber atrophy and contractile inactivity, termed ventilator-induced diaphragm dysfunction. Phosphoinositide 3-kinase-γ (PI3K-γ) is crucial modulating fibrogenesis during the reparative phase of ALI; however, mechanisms regulating interactions among MV, fibrosis, PI3K-γ remain unclear. We hypothesized that MV or without bleomycin treatment would increase muscle fibrosis through pathway. Five...
Mechanical ventilation (MV) is essential for patients with sepsis-related respiratory failure but can cause ventilator-induced diaphragm dysfunction (VIDD), which involves diaphragmatic myofiber atrophy and contractile inactivity. Mitochondrial DNA, oxidative stress, mitochondrial dynamics, biogenesis are associated VIDD. Hypoxia-inducible factor 1α (HIF-1α) crucial in the modulation of immune responses. The mechanism through HIF-1α mitochondria affect injury unknown. We hypothesized that MV...
Hyperphenylalaninemia predicts poor outcomes in patients with cardiovascular disease. However, the prognostic value and factors associated stress hyperphenylalaninemia (SHP) were unknown critical cardiac ICU.
Recent studies reported that driving pressure has been associated with increased mortality in acute respiratory distress syndrome (ARDS) patients. We aimed to explore the association between 28-day and patients severe pneumonia without ARDS. In total, 207 non-ARDS were enrolled. Serial pressures recorded daily for either 21 days or until ventilator support was no longer required. The relationships all variables analyzed using binary logistic regression analyses. Non-survivors (56 patients)...
A ntigen-presenting cells, such as monocytes and macro- phages, are the primary source of interleukin (IL)-12.Importantly, IL-12 induces polarization CD4 + T cells to helper 1 (Th1) phenotype that mediates immunity against intracellular pathogens. [1]Acute hyperglycemia influences innate immune system. [2]IL-12 responses from peripheral blood mononuclear (PBMCs) were influenced by glucose insulin. [3]The production in high-risk insulin-dependent diabetes mellitus (DM) subjects was increased...
Apoptosis is one of the causes immune depression in sepsis. Pyroptosis also occurs The toll-like receptor (TLR) 4 and for advanced glycation end products (RAGE) have been shown to play important roles apoptosis pyroptosis. However, it still unknown whether TLR4 inhibition decreases sepsis.Stimulated peripheral blood mononuclear cells (PBMCs) with or without lipopolysaccharides (LPS) high-mobility group box 1 (HMGB1) were cultured using monoclonal antibodies from 20 patients Caspase-3,...
Mechanical ventilation (MV) used in patients with acute lung injury (ALI) induces inflammation and causes fibroblast proliferation excessive collagen deposition-a process termed epithelial-mesenchymal transition (EMT). Phosphoinositide 3-kinase-γ (PI3K-γ) is crucial modulating EMT during the reparative phase of ALI; however, mechanisms regulating interactions among MV, EMT, PI3K-γ remain unclear. We hypothesized that MV or without bleomycin treatment would increase through pathway. C57BL/6...
Interleukin (IL)-10 response is associated with mortality in patients sepsis. IL-10 primarily produced by monocytes and type 2 T helper (Th2) cells. The aim of this study was to investigate differences production between Th2 cells Forty sepsis 35 healthy controls were enrolled. Cytokine expressions peripheral blood mononuclear (PBMCs) measured flow cytometry. expression the septic higher than controls, but lower controls. After regression analysis, positively sepsis, not or shock. In conclusion,