A unique spatial arrangement of amide groups for CO2 adsorption is found in the open-ended channels a zinc(II)-organic framework {[Zn4(BDC)4(BPDA)4]·5DMF·3H2O}n (1, BDC = 1,4-benzyl dicarboxylate, BPDA N,N'-bis(4-pyridinyl)-1,4-benzenedicarboxamide). Compound 1 consists 4(4)-sql [Zn4(BDC)4] sheets that are further pillared by long linker and forms 3D porous with an α-Po 4(12)·6(3) topology. Remarkably, unsheltered provide positive cooperative effect on molecules, as shown significant...

Abstract Background Bronchiectasis is a chronic infectious respiratory disease with diverse causes and ethnic or geographic differences. However, few large-scale studies of its etiology have been conducted in Asia. This study aimed to determine the clinical features bronchiectasis Taiwan. Methods longitudinal cohort investigated newly diagnosed non-cystic fibrosis patients from January 2002 December 2016. The clinical, functional microbiological data were retrieved Chang Gung Research...

Obstructive sleep apnea (OSA) has been associated with increased cancer incidence and mortality. The aim of this study was to investigate cancer-related mortality, overall survival progression free in patients suspected OSA lung cancer.

Abstract Purpose Multidrug-resistant (MDR) bacteria impose a considerable health-care burden and are associated with bronchiectasis exacerbation. This study investigated the clinical outcomes of adult patients following MDR bacterial infection. Methods From Chang Gung Research Database, we identified infection from 2008 to 2017. The control group comprised who did not have were propensity-score matched at 1:2 ratio. main in-hospital 3-year mortality. Results In total, 554 both identified....

Background: Non-pharmaceutical interventions (NPIs) were widely used during the coronavirus disease 2019 (COVID-19) pandemic, however their impact on acute asthma exacerbations (AEs) is not well studied.Methods: We had retrospectively collected patients with AEs between and 2020 retrieved data from Chang Gung Research Database, including clinical manifestations, medications, pulmonary function, clinic emergency department visits hospitalizations.Results: A total of 39,108 adult enrolled,...

Bronchiectasis is characterized by systemic inflammation and multiple comorbidities. This study aimed to investigate the clinical outcomes based on bronchiectasis etiology comorbidity index (BACI) score in patients hospitalized for severe exacerbations. We included non-cystic fibrosis exacerbations between January 2008 December 2016 from Chang Gung Research Database (CGRD) cohort. The main outcome was 1-year mortality rate after used Cox regression model assess risk factors of mortality. Of...

Chronic asthma is associated with progressive airway remodeling, which may contribute to declining lung function. An increase in matrix metalloproteinases-9 (MMP-9)/tissue inhibitor metalloproteinase-1 (TIMP-1) indicate inflammation and bronchial injury. Bronchial biopsy specimens alveolar macrophages (AMs) were obtained from patients under regular treatment inhaled corticosteroids or combination therapy normal subjects (n = 10). Asthmatics included those a slow forced expiratory volume one...

Influenza infection is a cause of exacerbations in patients with chronic pulmonary diseases. The aim this study was to investigate the clinical outcomes and identify risk factors associated hospitalization mortality following influenza adult bronchiectasis. Using Chang Gung Research Database, we identified bronchiectasis influenza-related (ICD-9-CM 487 anti-viral medicine) between 2008 2017. main were in-hospital rate. Eight hundred sixty-five identified. Five thirty-six (62%) hospitalized...

Summary Vitamin D receptor (VDR) mediates various biochemical activities between the cytoplasm and nucleus in cell. The nucleotide-binding, oligomerization domain (NOD)-like family, pyrin containing 3 (NLRP3) protein is involved T helper type 2 (Th2) response. This study tests a hypothesis that VDR interacts with NLRP3 to restrict Th2-biased In this study, VDR−/− mice WT (WT) were used. Th2 cell differentiation was observed. We observed CD4+ activation higher mice. VDR−/−CD4+ cells prone...

A flexible metal-organic framework, {[Mn2(2,6-ndc)2(bpda)2]⋅5DMF}n (1, 2,6-ndc=2,6-naphthalene dicarboxylate, bpda=N,N′-bis(4-pyridinyl)-1,4-benzene dicarboxamide) was successfully synthesized under solvothermal conditons. structural analysis showed that compound 1 is comprised of a 2-fold interpenetrating network with amide groups exposed in the channels. The flexibility framework verified by in-situ temperature-dependent PXRD studies. regular arrangement provided significant amide-CO2 and...

Previous research revealed a positive correlation between endothelial cell injury (indicated by albuminuria) and obstructive sleep apnea (OSA). However, little else has been about acute kidney (AKI) in patients with OSA.This prospective study recruited consecutive undergoing overnight polysomnography for evaluation of apnea. Patients whom any major disease or recent infection had previously diagnosed were excluded. Ultimately, data from 75 apnea-hypopnea indices 5 more analyzed. Baseline...

The prevalence of nontuberculous mycobacteria (NTM) in patients with chronic respiratory disease has increased. implication NTM non-CF bronchiectasis remained controversial. This study investigated the impact Taiwan. Clinical manifestation, imaging, and microbiological data were retrieved from Chang Gung Research Database, largest electronic medical record-based database Patients during 2001-2016 included. Cox proportional hazard model was employed to compare outcomes between negative...

Airway hyperresponsiveness (AHR) is associated with airway inflammation and a rapid decline in lung function predictor of future risk COPD among smokers. Alveolar macrophages (AMs) from patients release greater amount matrix metalloproteinase (MMP)-9. We hypothesized that the imbalance between MMP-9 tissue inhibitor metalloproteinase-1 (TIMP-1) related to AHR smokers.Healthy smokers (AHR + S) or without - S; divided according methacholine challenge test) nonsmokers NS) were enrolled....

Invasive pulmonary mold infection usually has devastating outcomes. Timely differentiation between invasive aspergillosis (IPA) from mucormycosis (PM) is critical for treatment decision-making. However, information on IPA and PM limited.We conducted a retrospective, multicenter, observational study, with proven probable patients January 2004 to December 2017. Demographics, clinical manifestations, image reports, histopathological findings, outcomes were analyzed.A total of 46 (33 13...

Mechanical ventilation (MV) is required to maintain life for patients with sepsis-related acute lung injury but can cause diaphragmatic myotrauma muscle damage and weakness, known as ventilator-induced diaphragm dysfunction (VIDD). Hypoxia-inducible factor 1α (HIF-1α) plays a crucial role in inducing inflammation apoptosis. Low-molecular-weight heparin (LMWH) was proven have anti-inflammatory properties. However, HIF-1α LMWH affect has not been investigated. We hypothesized that would reduce...

Neurological dysfunction is a common condition necessitating prolonged mechanical ventilation (PMV). We investigated the clinical features and outcomes of patients with acute neurological diseases requiring PMV.This retrospective observational study was conducted at Respiratory Care Center (RCC) Chang Gung Memorial Hospital, Taiwan, between January 2011 2014. The main outcome weaning success, defined as successful withdrawal from ventilator support for more than 5 days.The included 103...

Treatment responsiveness to corticosteroids is excellent for cryptogenic organizing pneumonia (COP) and sarcoidosis, but suboptimal idiopathic pulmonary fibrosis (IPF)/usual interstitial (UIP). We hypothesise that the differential expression of IL-17 contributes variable corticosteroid sensitivity in different lung diseases.To determine associations among IL-17, glucocorticoid receptor-β treatment diseases.Immunohistochemical (IHC) staining was performed on formalin-fixed paraffin-embedded...

Background: Lung cancers are common worldwide. First-line targeted therapy and chemotherapy both standard treatments in the current guidelines. With development of new anticancer therapy, lifespan patients with late-stage lung cancer has increased. Cardiovascular events can occur during treatment. This observational study aimed to report incidence major adverse cardiovascular (MACE) after treatment using real-world data. Objectives: Patients diagnosed advanced-stage between January 2011...

Osteoporosis is a common comorbidity in non-cystic fibrosis (non-CF) bronchiectasis patients. We determined whether desaturation during 6-min walk test (6MWT) can be predictor for osteoporosis risk.This was retrospective cross-sectional study. Sixty-six non-CF patients were enrolled. Lung function, walking distance, the lowest oxygen saturation (SpO2), fall SpO2 (ΔSpO2), and distance-saturation product (DSP) 6MWT. Desaturators (n = 45) defined as those with ΔSpO2 > 10% or < 88%. Bone mineral...

Prolonged mechanical ventilation (PMV) is associated with poor outcomes and a high economic cost. The association between protein intake PMV has rarely been investigated in previous studies. This study aimed to investigate the impact of on weaning from ventilation. Patients (mechanical ≥6 h/day for ≥21 days) at our hospital December 2020 April 2022 were included this study. Demographic data, nutrition records, laboratory conditions, survival data retrieved patient’s electronic medical...

Type 1 CD4+ T helper (Th1) cells mediate resistance to Mycobacterium tuberculosis (Mtb), and Th2 immunity generates specific immunoglobulin E upon allergen exposure. We investigated the impact of active (TB), atopic status, anti-TB treatment on balance between Th1 (type 2 helper) immunity. CD4+/interferon (IFN)-γ+ (%Th1) CD4+/interleukin-4+ (%Th2) in bronchoalveolar lavage (BAL) fluid peripheral blood mononuclear (PBMCs) were measured by flow cytometry. The BAL %Th1 was higher TB patients at...

To support more efficient parallel processing, Network-on-Chip (NoC) is being increasingly adopted as a new alternative interconnection architecture. With the limited number of processing elements (PEs) on an NoC, to perform application tasks efficiently PEs has become key issue. In this work, we propose hierarchical and dependency-aware (HDA) task mapping that covers concepts spatial inter-task dependency (temporal) enhance elasticity mapping. Experiments also show that, compared existing...