A5063470346- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- Allergic Rhinitis and Sensitization
- Tracheal and airway disorders
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Immune Response and Inflammation
- Inhalation and Respiratory Drug Delivery
- Immune cells in cancer
- Pneumonia and Respiratory Infections
- Pleural and Pulmonary Diseases
- Climate Change and Health Impacts
- Pediatric health and respiratory diseases
- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
- Lung Cancer Treatments and Mutations
- IL-33, ST2, and ILC Pathways
- Lung Cancer Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroscience of respiration and sleep
Taipei Medical University
2020-2024
Taipei Medical University Hospital
2020-2024
Tzu Chi Foundation
2023
Chang Gung Memorial Hospital
2007-2019
Chang Gung University
2008-2019
Memorial Hospital of South Bend
2007-2016
Linkou Chang Gung Memorial Hospital
2011-2012
Taoyuan Chang Gung Memorial Hospital
2007-2012
Taipei Medical University-Shuang Ho Hospital
2011
In-Q-Tel
2011
The self-management of asthma can improve clinical outcomes. Recently, mobile telephones have been widely used as an efficient, instant personal communication tool. This study investigated whether a self-care system will achieve better control through telephone-based interactive programme. was prospective, controlled in outpatient clinics. From 120 consecutive patients with moderate-to-severe persistent asthma, 89 were eventually recruited for the study, 43 telephone group (with system). In...
A proportion of patients with asthma present chronic airflow obstruction (CAO). We hypothesized that this effect may result from increased activity circulating fibroblast-like progenitor cells (fibrocytes) could home to the airway mucosal wall.To compare proportion, proliferation, and differentiation fibrocytes CAO or no (NOA) control subjects.We investigated in 11 a rapid decline FEV(1), 9 NOA, 10 nonasthmatic subjects. Blood nonadherent non-T (NANT) were incubated fetal calf serum each...
1. We studied the effect of capsaicin and sensory neuropeptides on tracheal goblet cell secretion in anaesthetized guinea‐pigs using a semi‐quantitative morphometric technique whereby magnitude discharge stained intracellular mucus, expressed as mucus score (MS), was related inversely to discharge. 2. Capsaicin (i.v.) induced secretion: decrease 50% MS below control (indicative increased secretion) maximal at 3.3 x 10(‐9) mol/kg. 3. Capsaicin‐induced unaffected either by prior vagus nerve...
Our study investigated whether tumor-associated macrophages (TAMs) in advanced non-small cell lung cancer (NSCLC) are related to treatment response epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and may be a predictor of survival. Of 206 NSCLC patients treated (first-line) with an EGFR-TKI at the hospital from 2006 2009, 107 adequate specimens for assessing CD68 immunohistochemistry as marker TAMs were assessed. After treatment, was observed 55 (51%) patients, median...
We studied the neural control of goblet cell secretion in lower airways anesthetized guinea pigs using a semiquantitative morphometric technique. The magnitude discharge intracellular mucus was determined histological sections trachea and main bronchi stained for glycoproteins. Bilateral electrical stimulation cervical vagus nerves induced secretion. effect dependent on frequency, voltage, pulse width stimulus, duration stimulation. At 10 Hz, 5 V, ms 3 min, there 62% decrease amount below...
Journal Article A biologically inspired lung-on-a-chip device for the study of protein-induced lung inflammation Get access Tushar H. Punde, Punde Institute NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu, Taiwan, Republic China Search other works by this author on: Oxford Academic Google Scholar Wen-Hao Wu, Wu Department Power Mechanical Engineering, China. Tel: +886-3-5742496 Pei-Chun Lien, Lien Molecular Cellular Biology, Medical Science, Ya-Ling Chang, Chang...
Studies in respiratory diseases other than chronic obstructive pulmonary disease suggest potentially differing responses to medications among patients from different regions. We report a subgroup analysis of recruited Asian centres previously reported 4-year COPD trial.Subgroup randomized, double-blinded, placebo-controlled trial tiotropium 18 µg daily COPD. Primary end-point was rate decline FEV(1) . Secondary end-points included spirometry at individual time points, health-related quality...
Background and objectives: Chronic obstructive pulmonary disease (COPD) is responsible for significant morbidity mortality worldwide. We evaluated the characteristics of stable COPD patients in pulmonology clinics seven Asian cities also whether exposure to biomass fuels dusty jobs were related respiratory symptoms, airflow limitation, quality life patients. Methods: This cross-sectional observational study recruited 922 from Asia. The underwent spirometry administered questionnaires about...
Aspiration of the lower airways due to foreign body is rare in adults. This study aimed determine outcome patients who received flexible bronchoscopy with different modalities for removal airways.Between January 2003 and 2014, 94 diagnosed underwent modalities, which included forceps, loop, basket, knife, electromagnet, cryotherapy. The clinical presentation, location characteristics, applications were analyzed.Forty (43%) had acute aspiration, developed within one week entry 54 (57%)...
Cancer immunotherapy has been regarded as a promising strategy for cancer therapy by blocking immune checkpoints and evoking immunity to fight cancer, but its efficacy seems be heterogeneous among patients. Manipulating the gut microbiota is potential enhancing of immunotherapy. Here, we report that MS-20, also known "Symbiota®", postbiotic comprises abundant microbial metabolites generated from soybean-based medium fermented with multiple strains probiotics yeast, inhibited colon lung...
This study investigated the role of protein kinase C (PKC) and transcription factor nuclear factor‐κB (NF‐κB) in cyclooxygenase‐2 (COX‐2) expression caused by lipoteichoic acid (LTA), a cell wall component gram‐positive bacterium Staphylococcus aureus , human pulmonary epithelial line (A549). LTA dose‐ time‐dependent increases COX‐2 COX activity, dose‐dependent increase PGE 2 release A549 cells. The LTA‐induced activity were markedly inhibited dexamethasone, actinomycin D or cyclohexamide,...
ABSTRACT Background and objective: Roflumilast, an oral, selective phosphodiesterase 4 inhibitor, has been shown to reduce exacerbations improve pulmonary function in patients with COPD. This study examined the efficacy, safety tolerability of roflumilast Asian Methods: Patients COPD were randomized 1:1 enter a 12‐week treatment period receive either oral roflumilast, 500 µg once daily, or placebo, following single‐blind, 4‐week baseline which all received placebo. The primary end point was...
Abstract Background Reduction of histone deacetylase (HDAC) 2 expression and activity may contribute to amplified inflammation in patients with severe asthma. Connective tissue growth factor (CTGF) is a key mediator airway fibrosis However, the role HDAC2/Sin3A/methyl-CpG-binding protein (MeCP) corepressor complex regulation CTGF lung fibroblasts remains unclear. Methods The HDAC2/Sin3A/MeCP2 endothelin (ET)-1-stimulated production human (WI-38) was investigated. We also evaluated HDAC2,...
To determine plasma concentrations of angiopoietin (Ang)-1, Ang-2, Tie-2, and vascular endothelial growth factor (VEGF) in patients with sepsis-induced multiple organ dysfunction syndrome (MODS) their association mortality. The study prospectively recruited 96 consecutive severe sepsis a l intensive care unit tertiary hospital. Plasma Ang-1, VEGF levels MODS were determined on days 1, 3, 7 sepsis. Univariate Cox proportional hazards analysis performed to develop prognostic model. Days Ang-1...
Abstract Background and objective Circulating fibrocytes act as precursors of myofibroblasts, contribute to airway remodelling in chronic asthma migrate injured tissues by expressing CXCR4 CCR7. Anti‐IgE therapy improves severe allergic (SAA) control T2‐high SAA. The effects anti‐IgE on fibrocyte activities were investigated this study. Methods expression CCR7, CXCR4, ST2 α‐SMA (α‐smooth muscle actin) both circulating cultured from all patients with was measured, repeated after omalizumab...
Although high-affinity immunoglobulin (Ig)E receptor (FcεRI) expression is upregulated in type 2 (T2)-high asthmatic airway epithelium, its functional role epithelial dysfunction has not been elucidated. Here we report the of FcεRI and p-EGFR (Epidermal Growth Factor Receptor), associated with decreased E-cadherin claudin-18 bronchial biopsies severe T2-high asthmatics compared to mild allergic non-T2 asthmatics. Monomeric IgE (mIgE) junction proteins, E-cadherin, claudin-18, ZO-1, increased...
OBJECTIVESThe diagnosis of peripheral pulmonary lesions (PPLs) often involves endobronchial ultrasound (EBUS)-guided transbronchial biopsy (TBB), washing and brushing. Certain echoic features PPL have been associated with yield. This study compared yields TBB bronchial (TBBW) those TBBW plus brushing analysed the associations between clinical
Airway hyperresponsiveness (AHR) is associated with airway inflammation and a rapid decline in lung function predictor of future risk COPD among smokers. Alveolar macrophages (AMs) from patients release greater amount matrix metalloproteinase (MMP)-9. We hypothesized that the imbalance between MMP-9 tissue inhibitor metalloproteinase-1 (TIMP-1) related to AHR smokers.Healthy smokers (AHR + S) or without - S; divided according methacholine challenge test) nonsmokers NS) were enrolled....
Introduction Angiotensin-converting enzyme 2 (ACE2) provides an adhesion site for severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. Patients with COPD could have outcomes after SARS-CoV-2 The objective of this study was to investigate ACE2 regulation by air pollution during the development COPD. Methods Sprague Dawley rats were exposed unconcentrated traffic-related 3 and 6 months. We examined lung injury markers, oxidative stress, inflammation, emphysema, angiotensin II...