A5077394728- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Diabetes Treatment and Management
- Angiogenesis and VEGF in Cancer
- Metabolomics and Mass Spectrometry Studies
- Heart Rate Variability and Autonomic Control
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Diet and metabolism studies
- Acute Myocardial Infarction Research
- Artificial Intelligence in Healthcare
- Pancreatic function and diabetes
- Metabolism and Genetic Disorders
- Metabolism, Diabetes, and Cancer
- Atherosclerosis and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Advanced Memory and Neural Computing
- Hemodynamic Monitoring and Therapy
- Coronary Interventions and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Advanced MRI Techniques and Applications
- Nutrition and Health in Aging
Chang Gung University
2016-2025
Keelung Chang Gung Memorial Hospital
2016-2025
Chang Gung Memorial Hospital
2015-2024
National Cheng Kung University
2010-2023
Memorial Hospital of South Bend
1999-2023
Mackay Memorial Hospital
2007-2022
Macronix International (Taiwan)
2016-2020
GTx (United States)
2020
National Taiwan University
2017
Tao Yuan General Hospital
2014
Background— Given the central importance of nitric oxide (NO) in development and clinical course cardiovascular diseases, we sought to determine whether powerful predictive value C-reactive protein (CRP) might be explained through an effect on NO production. Methods Results— Endothelial cells (ECs) were incubated with recombinant CRP (0 100 μg/mL, 24 hours), cyclic guanosine monophosphate (cGMP) production was assessed. The effects endothelial synthase (eNOS) protein, mRNA expression,...
Adipocyte-derived hormones may represent a mechanism linking insulin resistance to cardiovascular disease. In the present study, we evaluated direct effects of resistin, novel adipocyte-derived hormone, on endothelial activation.Endothelial cells (ECs) were incubated with human recombinant resistin (10 100 ng/ML, 24 hours), and endothelin-1 (ET-1) release, ET-1 mRNA expression, nitric oxide (NO) production assessed. Transient transfection assays used evaluate transcription gene promoter....
Background— Accumulating evidence suggests that C-reactive protein (CRP), in addition to predicting vascular disease, may actively facilitate lesion formation by inciting endothelial cell activation. Given the central importance of angiotensin type 1 receptor (AT -R) pathogenesis atherosclerosis, we examined effects CRP on AT -R expression and kinetics smooth muscle (VSM) cells. In addition, VSM migration, proliferation, reactive oxygen species (ROS) production were evaluated presence...
Carrier concentration in a piezoelectric semiconductor greatly affects alternating current (AC) nanogenerators (NGs) because of the carrier screening effect on potential. The output performance series NGs is investigated by tuning Si dopant GaN nanowires. results show strong that degrades for high doping concentrations but power low concentrations. As service to our authors and readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may be...
This investigation explored how aerobic interval training influences central or peripheral hemodynamic response(s) to exercise in patients with heart failure (HF) preserved ejection fraction (HFpEF) those HF reduced (HFrEF).One hundred twenty were divided into four groups: HFpEF and HFrEF (3-min intervals at 40% 80% VO2peak for 30 mins/day, 3 days/wk 12 wks) general health care groups. Exercise hemodynamics the heart, frontal cerebral lobe, vastus lateralis muscle, oxygenation lobe muscle...
Abstract Aims Fluid accumulation is associated with poor outcomes in patients heart failure (HF). After acute HF, HF nurses provide home care suggestions based on oedema status assessed at outpatient clinics. However, the pattern of serial changes and their associations patient are unknown. We investigated trajectories bioimpedance analysis (BIA)–derived index (EI) following prognostic value. Methods results This was a retrospective cohort study. recruited 761 hospitalized for HF....
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists inhibit vascular smooth muscle proliferation and migration improve endothelial function. It is unknown whether PPAR-gamma favorably modulate bone marrow (BM)-derived angiogenic progenitor cells (APCs) to promote lineage differentiation early reendothelialization after intervention.C57/BL6 mice, treated with or without rosiglitazone (8 mg/kg per day), a agonist, underwent femoral angioplasty. Rosiglitazone treatment...
Mesenchymal stem cells (MSCs) are one of a number cell types undergoing extensive investigation for cardiac regeneration therapy. It has not yet been determined whether this therapy also substantially contributes to vascular remodeling diseased vessels.Human MSCs and variety progenitor were used in vitro vivo experiments. Wire-induced injury mobilized into the circulation. Compared with human aortic smooth muscle cells, exhibited 2.8-fold increase adhesion capacity (P<0.001) 6.3-fold...
Resistive random access memory (ReRAM) is often considered as a strong candidate for storing the weights in non-von Neumann neuromorphic computing systems. This paper studies how nonideal characteristics, which include programing error, read fluctuation, and retention, affect inference accuracy of analog ReRAM neural networks by incorporating characteristics extracted from 1-Mb into simulated inference-only network. also shows that different layer network can tolerate amount such imperfects....
Abstract Aims Previous studies found a relationship between elevated phenylalanine levels and poor cardiovascular outcomes. Potential strategies are available to manipulate metabolism. This study investigated whether increased predicted mortality in critical patients with either acute heart failure (HF) or on chronic HF, its correlation inflammation immune cytokines. Methods results recruited 152 subjects, including 115 HF admitted for conditions 37 normal controls. We measured left...
Article1 October 1948A NOTE ON CORONARY OCCLUSION AND MYOCARDIAL INFARCTION FOUND POST MORTEM AT THE MASSACHUSETTS GENERAL HOSPITAL DURING TWENTY YEAR PERIOD FROM 1926 TO 1945 INCLUSIVEC. H. WANG, EDWARD F. BLAND, PAUL D. WHITE, F.A.C.P.C. F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-4-601 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHeart disease as a cause of...
Sepsis is a multifactorial, and often fatal, disorder typically characterized by widespread inflammation immune activation with resultant endothelial activation. In the present study, we postulated that adipokine adiponectin serves as critical modulator of survival in sepsis. To this aim, evaluated both loss-of-function (adiponectin gene-deficient mice) subsequent gain-of-function (recombinant reconstitution) strategies two well-established inflammatory models, cecal ligation perforation...
Patients with heart failure experience adverse physical symptoms that affect quality of life. The number patients in Taiwan has been growing recent years.This article examines correlations among illness knowledge, self-care behaviors, and life elderly failure.A cross-sectional research design using three questionnaires was adopted. study undertaken an outpatient department a teaching hospital from January to June 2008. Potential participants aged 65 years or older were selected by physician...
To investigate the prognostic value of phenylalanine and leucine in patients with severe infection.Ninety-three infection who had a quick Sequential Organ Failure Assessment (qSOFA) score ≥2 were enrolled. Plasma phenylalanine, leucine, albumin, C-reactive protein, pre-albumin, transferrin measured SOFA at enrollment was calculated after hospitalization.During 3-month follow-up, 30 (32.3%) died. Death associated higher scores, incidence bacteremia admission to intensive care unit, protein...
Lipids play an important role in the pathogenesis of cardiovascular disease. Changes lipids erythrocytes are indicative outcome pathophysiological processes. In present study, we assessed whether lipid profiles from heart failure (HF) patients informative their disease risk. The lipidomes 10 control subjects and 29 at different HF stages were analyzed using liquid chromatography time-of-flight mass spectrometry. composition obtained was significantly that normal controls. levels...