A5112876377- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Diabetes Treatment and Management
- Body Composition Measurement Techniques
- Cardiac Arrhythmias and Treatments
- Angiogenesis and VEGF in Cancer
- Cardiovascular Disease and Adiposity
- Hemodynamic Monitoring and Therapy
- Cardiac Structural Anomalies and Repair
- Pancreatic function and diabetes
- Atrial Fibrillation Management and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- ECG Monitoring and Analysis
- Hormonal Regulation and Hypertension
- Mesenchymal stem cell research
- Dialysis and Renal Disease Management
- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- Metabolism, Diabetes, and Cancer
- Cardiovascular and exercise physiology
- Acute Myocardial Infarction Research
- Chronic Kidney Disease and Diabetes
- Takotsubo Cardiomyopathy and Associated Phenomena
Keelung Chang Gung Memorial Hospital
2008-2025
Chang Gung Memorial Hospital
2008-2024
Chang Gung University
2011-2024
Tao Yuan General Hospital
2014
Memorial Hospital of South Bend
2004-2013
Cheng Hsin General Hospital
2012
National Health Research Institutes
2012
Institute of Cardiology
2011
Mackay Memorial Hospital
2007
Taipei Medical University
2007
This investigation explored how aerobic interval training influences central or peripheral hemodynamic response(s) to exercise in patients with heart failure (HF) preserved ejection fraction (HFpEF) those HF reduced (HFrEF).One hundred twenty were divided into four groups: HFpEF and HFrEF (3-min intervals at 40% 80% VO2peak for 30 mins/day, 3 days/wk 12 wks) general health care groups. Exercise hemodynamics the heart, frontal cerebral lobe, vastus lateralis muscle, oxygenation lobe muscle...
Abstract Background To determine whether glucagon-like peptide 1 receptor agonists (GLP-1RAs) have cardiovascular and renal protective effects in patients with advanced diabetic kidney disease (DKD) an estimated glomerular filtration rate (eGFR) < 30 mL/min per 1.73 m 2 . Methods In this cohort study, type diabetes mellitus eGFR a first prescription for GLP-1RAs or dipeptidyl peptidase 4 inhibitors (DPP-4is) from 2012 to 2021 (n = 125,392) were enrolled. A Cox proportional hazard model...
Abstract Aims Fluid accumulation is associated with poor outcomes in patients heart failure (HF). After acute HF, HF nurses provide home care suggestions based on oedema status assessed at outpatient clinics. However, the pattern of serial changes and their associations patient are unknown. We investigated trajectories bioimpedance analysis (BIA)–derived index (EI) following prognostic value. Methods results This was a retrospective cohort study. recruited 761 hospitalized for HF....
Mesenchymal stem cells (MSCs) are one of a number cell types undergoing extensive investigation for cardiac regeneration therapy. It has not yet been determined whether this therapy also substantially contributes to vascular remodeling diseased vessels.Human MSCs and variety progenitor were used in vitro vivo experiments. Wire-induced injury mobilized into the circulation. Compared with human aortic smooth muscle cells, exhibited 2.8-fold increase adhesion capacity (P<0.001) 6.3-fold...
Type 2 diabetes is a global health problem that associated with wide variety of vascular complications and morbidity mortality. Klotho an enzyme transmembrane protein, increasing evidence suggests may contribute to reduced oxidative stress, improved endothelial function, vasoprotection. To date, the physiological role in unclear.We prospectively recruited 252 patients type diabetes, who visited outpatient clinic at our hospital between 2009 2011. Patients top bottom tertiles circulating...
A segmental multifrequency bioelectrical impedance analysis (SMBIA) is a noninvasive and reproducible modality for estimating the fluid state. The aim of this study was to test whether SMBIA-derived edema index provides prognostic value in patients hospitalized due acute heart failure (AHF).To estimate 6-month predischarge AHF, 112 were consecutively enrolled. Both B-type natriuretic peptide (BNP) measured. Outcome follow-up focused on failure-related all-cause re-hospitalizations all...
Multidisciplinary disease management programmes (MDPs) for heart failure have been shown to be effective in Western countries. However, it is not known whether they improve outcomes a high population density country with national health insurance programme.In total, 349 patients hospitalized because of were randomized into control and MDP groups. All-cause death re-hospitalization related analyzed. The median follow-up period was approximately 2 years.Mean patient age 60 years; 31% women;...
Background: Sodium-glucose cotransporter 2 inhibitors have been demonstrated to promote reverse cardiac remodeling in people with diabetes or heart failure. Although it has theorized that sodium-glucose might afford similar benefits without prevalent failure, this not evaluated. We sought determine whether inhibition empagliflozin leads a decrease left ventricular (LV) mass type significant Methods: Between April 2021 and January 2022, 169 individuals, 40 80 years of age, but risk factors...
Cyclosporin A (CsA) improves the success rate of transplantation. The CD26/dipeptidylpeptidase IV (DPP IV) system plays a critical role in mobilizing endothelial progenitor cells (EPCs) from bone marrow. This study investigated whether CsA manipulates CD26/DPP activity and increases EPC mobilization. C57BL/6 mice were divided into control CsA-treated groups. Before after hindlimb ischemia was induced, circulating number serum levels different cytokines measured. Compared with controls,...
Aim: This case-control study aimed to investigate the interrelations of body measurements and selected biomarkers in type 2 diabetes mellitus (T2DM). Methods: We recruited 98 patients with T2DM controls from 2016 2018 Taiwan. Body were obtained using a three-dimensional surface scanning system. Four related insulin resistance, adipokines, inflammation assayed. A multiple logistic regression model was used perform multivariable analyses. Results: measurements, namely waist circumference (odds...
Dual antiplatelet therapy (DAPT) with ticagrelor or adjusted-dose prasugrel has been used for acute coronary syndrome (ACS). However, few studies have directly compared these two drugs. In this study, we the real-world applications and outcomes of drugs in patients ACS who had undergone percutaneous intervention (PCI). This retrospective cohort study was conducted using data eligible PCI at Chang Gung Memorial Hospital System between June 2019 December 2021. The primary efficacy-related...
The efficacy of heart failure (HF) management programs is compromised by the challenge early identification patients at imminent risk. Segmental multifrequency bioelectrical impedance analysis can generate an "edema index" (EI) as a surrogate for body fluid status. In this study, we tested whether integration EI-guided improved 6-month outcomes HF under multidisciplinary care. total, 159 with acute were randomized into control, case (CM), and CM groups (n = 53 in each group). EI group,...
Abstract The quest for rejuvenation and prolonged lifespan through transfusion of young blood has been studied decades with the hope unlocking mystery key substance(s) that exists in circulating juvenile organisms. However, a pivotal mediator yet identified. Here, atypical findings are presented observed knockin mouse model carrying lysine to arginine substitution at residue 74 Krüppel‐like factor 1 (KLF1/EKLF), SUMOylation‐deficient Klf1 K74R/K74R mouse, displayed significant improvement...
An increased serum interleukin-6 (IL-6) level is associated with an risk of cardiovascular events in healthy subjects. However, it unknown whether the IL-6 or genetic polymorphism correlated complexity coronary plaque patients stable artery disease (CAD). Patients CAD (n = 135) were divided into 3 groups: insignificant 77), simple 15), and complex 43). IL-6-174G > C levels C-reactive protein (CRP) investigated. No significant difference distribution genotypes was found among groups. The...
Background: Cardiac remodeling has been demonstrated in patients on hemodialysis and predialysis with chronic kidney disease (CKD). Using functional echocardiographic parameters to study the association of hemodynamic status CKD not yet established. Methods: From November 2007 September 2008, ninety‐six (50 men 46 women) different stages were enrolled consecutively undergo echocardiography. Group 1 consisted 27 mild (CKD 2) group 2 69 moderate/severe 3–5). Results: Higher values observed for...