A5019880256- Selenium in Biological Systems
- Medical and Biological Ozone Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Trace Elements in Health
- Nitric Oxide and Endothelin Effects
- Organoselenium and organotellurium chemistry
- Hydrogen's biological and therapeutic effects
- Vanadium and Halogenation Chemistry
- Redox biology and oxidative stress
- Heavy Metal Exposure and Toxicity
- Powder Metallurgy Techniques and Materials
- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Traditional and Medicinal Uses of Annonaceae
- Medicinal Plants and Neuroprotection
- Phytochemical compounds biological activities
University of Copenhagen
2014-2021
Atherosclerosis is a chronic inflammatory disease of the vasculature characterised by infiltration activated neutrophils and macrophages at sites damage within vessel wall, which contributes to lesion formation plaque progression. Selenomethionine (SeMet) an organic form selenium (Se), essential trace element that functions in regulation immune response both bolstering endogenous thioredoxin glutathione antioxidant defence systems directly scavenging damaging oxidant species. This study...
The production of hypochlorous acid (HOCl) by myeloperoxidase (MPO) plays a key role in immune defense, but also induces host tissue damage, particularly chronic inflammatory pathologies, including atherosclerosis. This has sparked interest the development therapeutic approaches that decrease HOCl formation during inflammation, use alternative MPO substrates. Thiocyanate (SCN−) supplementation decreases favouring hypothiocyanous (HOSCN), which is more selectively toxic to bacterial cells....
New drug candidates increasingly tend to be poorly water soluble. One approach increase their solubility is convert the crystalline form of a into amorphous form. Intrinsic dissolution testing an efficient standard method determine intrinsic rate (IDR) and test potential advantage However, neither United States Pharmacopeia (USP) nor European (Ph.Eur) state specific limitations for compression pressure in order obtain compacts IDR determination. In this study, influence different pressures...
Myeloperoxidase (MPO) is released by activated immune cells and forms the oxidants hypochlorous acid (HOCl) hypothiocyanous (HOSCN) from competing substrates chloride thiocyanate. MPO overproduction of HOCl are strongly linked with vascular cell dysfunction inflammation in atherosclerosis. highly reactive causes marked death, whereas data HOSCN conflicting, dependent on nature type. In this study we have examined reactivity human coronary artery smooth muscle (HCASMC), given key role type...