A5025073323- Cancer, Hypoxia, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Lipid metabolism and disorders
- Chemokine receptors and signaling
- Herpesvirus Infections and Treatments
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Systemic Lupus Erythematosus Research
- NF-κB Signaling Pathways
- Selenium in Biological Systems
- Cell Adhesion Molecules Research
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Medical and Biological Ozone Research
- Biomarkers in Disease Mechanisms
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Hydrogen's biological and therapeutic effects
The University of Sydney
2011-2019
The Heart Research Institute
2017-2019
Millennium Institute
2011
Atherosclerosis is a chronic inflammatory disease of the vasculature characterised by infiltration activated neutrophils and macrophages at sites damage within vessel wall, which contributes to lesion formation plaque progression. Selenomethionine (SeMet) an organic form selenium (Se), essential trace element that functions in regulation immune response both bolstering endogenous thioredoxin glutathione antioxidant defence systems directly scavenging damaging oxidant species. This study...
ABSTRACT Dendritic cells (DC) are antigen-presenting essential for initiating primary immune responses and therefore an ideal target viral evasion. Varicella-zoster virus (VZV) can productively infect immature human DCs impair their function as effectors by inhibiting maturation, evidenced the expression modulation of functionally important cell surface molecules CD80, CD86, CD83, major histocompatibility complex I. The NF-κB pathway largely regulates these molecules, we sought to determine...
Diabetic vascular complications are associated with impaired ischaemia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired microRNAs (miRNAs) regulate angiogenesis and transported within HDL to sites of injury/repair. The role miRNAs in the by rHDL is unknown. Using a miRNA array, we inhibits hsa-miR-181c-5p expression vitro using mimic antimiR identify novel anti-angiogenic for miR-181c-5p. was tracked over time post-hindlimb...
Chemokines are important in macrophage recruitment and the progression of atherosclerosis. The 'M3' chemokine binding protein inactivates key chemokines involved atherosclerosis (e.g. CCL2, CCL5 CX3CL1). We aimed to determine effect M3 on plaque development composition. In vitro chemotaxis studies confirmed that inhibited activity CX3CL1 as primary human monocyte migration well CCR2-, CCR5- CX3CR1-directed was attenuated by M3. vivo, adenoviruses encoding (AdM3) or green fluorescence (AdGFP;...
High-density lipoproteins augment hypoxia-induced angiogenesis by inducing the key angiogenic vascular endothelial growth factor A (VEGFA) and total protein levels of its receptor 2 (VEGFR2). The activation/ phosphorylation VEGFR2 is critical for mediating downstream, signaling events. This study aimed to determine whether reconstituted high-density lipoprotein (rHDL) activates downstream events importance in proangiogenic effects rHDL hypoxia. In vitro, increased activation enhanced...