A5082416983- Sperm and Testicular Function
- Reproductive System and Pregnancy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pregnancy and preeclampsia studies
- Nitric Oxide and Endothelin Effects
- Reproductive Biology and Fertility
- Healthcare Regulation
- Phytochemistry Medicinal Plant Applications
- Ovarian function and disorders
- Antioxidant Activity and Oxidative Stress
- Reproductive Physiology in Livestock
- Public Health in Brazil
- Diabetic Foot Ulcer Assessment and Management
- Maternal and Neonatal Healthcare
- Immunotherapy and Immune Responses
- Reproductive biology and impacts on aquatic species
- Wound Healing and Treatments
- Eicosanoids and Hypertension Pharmacology
- Anesthesia and Neurotoxicity Research
- Protease and Inhibitor Mechanisms
- Birth, Development, and Health
- Diagnosis and Treatment of Venous Diseases
- T-cell and B-cell Immunology
Universidade Estadual Paulista (Unesp)
2020-2024
Universidade Federal do Espírito Santo
2017
EPPIN is a sperm-surface drug target for male contraception. Here we investigated EPPIN-interacting proteins in mouse spermatozoa. We showed that an androgen-dependent gene, expressed the testis and epididymis, but also present vas deferens, seminal vesicle adrenal gland. Mature spermatozoa presented staining on head flagellum. Immunoprecipitation of from pre-incubated with fluid (SVF) followed by LC-MS/MS or Western blot revealed co-immunoprecipitation SVS2, SVS3A, SVS5 SVS6. In silico...
Abstract Whey-acidic protein four-disulfide core domain (WFDC) genes display putative roles in innate immunity and fertility. In mice, a locus on chromosome 2 contains 5 11 Wfdc its centromeric telomeric subloci, respectively. Although are highly expressed the epididymis, their contributions to epididymal function remain elusive. Here, we investigated whether regulated response lipopolysaccharide (LPS)-induced epididymitis, an inflammatory condition that impairs male We induced epididymitis...
Region-specific immune environments in the epididymis influence responses to uropathogenic Escherichia coli (UPEC) infection, a relevant cause of epididymitis men. Toll-like receptors (TLRs) are essential orchestrate against bacterial infections. The displays region-specific inflammatory bacterial-derived TLR agonists, such as lipopolysaccharide (LPS; TLR4 agonist) and lipoteichoic acid (LTA; TLR2/TLR6 agonist), suggesting that TLR-associated signaling pathways could magnitude epididymitis.
Abstract EPPIN (epididymal protease inhibitor) is a mammalian conserved sperm-binding protein displaying an N-terminal WFDC (whey-acidic four-disulfide core) and C-terminal Kunitz inhibitor domains. plays key role in regulating sperm motility after ejaculation via interaction with the seminal plasma SEMG1 (semenogelin-1). ligands targeting binding site domain are under development as male contraceptive drugs. Nevertheless, relative contributions of domains to function remain obscure. Here,...
A automedicação é um problema universal, portanto, gestantes também estão sujeitas a utilizarem medicamentos constantemente. Assim, o objetivo desse trabalho foi identificar utilização de e plantas medicinais junto às atendidas na Unidade Saúde da Mulher, no município Alegre, ES. O estudo realizado por meio entrevistas. Foram entrevistadas 115 gestantes, idade variou 14 43 anos. Dessas, 99,1% eram alfabetizadas, 48,69% não realizavam atividade remunerada. maioria das tinha renda familiar...
ABSTRACT Seeking and identifying biomarker molecules in inflammatory exudate of chronic venous ulcers (CVUs) can aid health professionals the healing prognosis. The therapeutic failure or cure is related to quantitative expression determinate proteins. This work aimed identify proteins expressed exudates from CVUs correlate them with reduction increase wound size. For 90 days, 28 participants that received standard treatment for 37 were monitored. collected before initiation (T=0) analyzed...
A Eugenia uniflora é uma planta amplamente encontrada no Brasil, utilizada popularmente para tratar diversos distúrbios. O objetivo deste estudo foi avaliar os efeitos do extrato de suas folhas sobre parâmetros hematológicos e pressão arterial ratos espontaneamente hipertensos (SHR). Os animais foram divididos em grupos controle tratados com nas doses 100mg/kg 200mg/kg. tratamento diário, via gavagem, por 28 dias. sangue dos coletado semanalmente, a contagem global diferencial leucócitos ao...
A Eugenia uniflora é uma planta amplamente distribuída no Brasil, utilizada popularmente para diversas desordens. O objetivo do trabalho foi avaliar os efeitos extrato de suas folhas sobre o perfil lipídico e parâmetros metabólicos Ratos Espontaneamente Hipertensos (SHR). Os animais foram divididos em grupos controle tratados com nas doses 100mg/kg 200mg/kg. tratamento diário, via gavagem, por 28 dias. pesagem dos semanal, ao final, colocados gaiolas metabólicas 24 horas a quantificação...