A5101981664- Laser Design and Applications
- Advancements in Photolithography Techniques
- Ubiquitin and proteasome pathways
- Solid State Laser Technologies
- Optical Systems and Laser Technology
- Electron and X-Ray Spectroscopy Techniques
- Advanced optical system design
- Laser Material Processing Techniques
- Water Treatment and Disinfection
- Birth, Development, and Health
- Advanced Sensor and Control Systems
- Industrial Automation and Control Systems
- Geochemistry and Elemental Analysis
- Robotic Mechanisms and Dynamics
- MicroRNA in disease regulation
- Geological and Geochemical Analysis
- Industrial Technology and Control Systems
- Epigenetics and DNA Methylation
- Connective tissue disorders research
- Microfluidic and Capillary Electrophoresis Applications
- RNA modifications and cancer
- Bone and Dental Protein Studies
- 3D IC and TSV technologies
- Laser-Matter Interactions and Applications
- Ocular and Laser Science Research
Sichuan University
2005-2024
State Key Laboratory of Biotherapy
2021-2024
ITMO University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2021
Suzhou Institute of Biomedical Engineering and Technology
2020
Chinese Academy of Sciences
2020
Aarhus University
2015-2017
Nankai University
2016
State Key Laboratory of Medicinal Chemical Biology
2016
Central South University
2015
PEGylation of cationic polyplexes is a promising approach to enhance the stability and reduce unspecific interaction with biological components. Herein, we systematically investigate impact on physical properties chitosan/siRNA polyplexes. A series chitosan-PEG copolymers (CS-PEG2k, CS-PEG5k CS-PEG10k) were synthesized similar PEG mass content but different molecular weight. higher weight less grafting degree resulted in smaller more compacted nanoparticles relatively surface charge....
Central precocious puberty (CPP) refers to a human syndrome of early initiation with characteristic increase in hypothalamic production and release gonadotropin-releasing hormone (GnRH). Previously, loss-of-function mutations MKRN3, encoding putative E3 ubiquitin ligase, were found contribute about 30% cases familial CPP. MKRN3 was thereby suggested serve as 'brake' mammalian onset, but the underlying mechanisms remain yet unknown. Here, we report that genetic ablation Mkrn3 did accelerate...
One of the hallmarks placental dysfunction is increase oxidative stress. This process, along with overexpression inflammasome, creates a downward spiral that can lead to series severe pregnancy complications. Ferroptosis form iron-mediated cell death involving accumulation reactive oxygen species, lipid peroxides. In this study, rats’ model stress abortion was established, and hydrogen peroxide (H 2 O ) used establish cellular RNAi, western blot, immunofluorescence were evaluate expression...
Vascular endothelial cell growth factor (VEGF) plays a pivotal role in promoting neovascularization. VEGF gene expression vascular cells normal tissues is maintained at low levels but becomes highly up-regulated variety of disease settings including cancers. Tumor necrosis superfamily 15 (TNFSF15; VEGI; TL1A) an anti-angiogenic cytokine prominently produced by vasculature. We report here that production mouse line bEnd.3 can be inhibited TNFSF15 via microRNA-29b (miR-29b) targets the 3'-UTR...
Chemoresistance is a main cause of chemotherapy failure and tumor recurrence. The effects global protein SUMOylation on chemoresistance in colorectal cancer (CRC) remains to be investigated. Herein, we have proposed that the elevated SUMO2/3-modified proteins confer 5-fluorouracil (5-FU) acquisition CRC. levels CRC cell lines were compared with normal colon line NCM460. 5-FU treatment obviously reduced 5-FU-sensitive cells including HT29, HCT116 HCT-8. However, 5-FU-resistant HCT-8/5-FU...
Although many studies have attempted to associate specific gene mutations with dentin phenotypic severity, it remains unknown how the in COL1A1 influence mechanical behavior of collagen and matrix. Here, we reported one osteogenesis imperfecta (OI) pedigree caused by two new inserting exon 5 (NM_000088.3:c.440_441insT;c.441_442insA), which resulted unstable expression mRNA half quantity procollagen production. We investigated morphological features proband's using atomic force microscope...
The composition and structure of the lower continental crust are great interest in understanding dynamic processes Earth interior. In this study, we examined relationships between magnetic properties opaque mineralogy a set mafic granulite xenoliths (derived from ∼24–41 km) collected Hannuoba region, north China (a region well known for its exposures crustal rocks). These weakly with an average susceptibility ( χ , mass specific) saturation isothermal remanent magnetization (SIRM) 5.87 × 10...
The measurement range of ceilometer depends both on its optical system characteristics and the properties electronic scheme, including detector. is required to have lowest possible number elements small size. Thus, it appears be promising optimize device by selecting detector laser characteristics. Signals received in scheme were compared for two types photodetector: first option was conventional APD detector, second one HD-SiPM objective study analog signals these detectors a that registers...
Illuminator is one of the important components extreme ultraviolet lithography system. Industrial illuminator uses two compound eyes and relay system, which can realize variety illumination modes. But manufacture assembly are difficult. Therefore, we would like to design illuminators, use such as Offner-relay quad elliptical mirrors, or other mirror systems. These systems do not have more complex surfaces, easier assembly. Analyze advantages disadvantages these systems, then discuss...
The significance of researching and developing thermal stabilization systems for end-pumped amplifiers in high-power lasers is evident modern optical laser technology. There are several key factors driving this importance. Firstly, have pivotal applications across diverse fields, including science, medicine, industry, defense. Secondly, generate substantial heat, resulting effects that impact their stability efficiency. Thirdly, the implementation enhances performance durability lasers. In...