A5040216288- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Occupational Health and Performance
- Heavy metals in environment
- Injury Epidemiology and Prevention
- Radioactivity and Radon Measurements
- Mercury impact and mitigation studies
- Radiation Dose and Imaging
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced X-ray and CT Imaging
- Noise Effects and Management
- Occupational and environmental lung diseases
- Effects and risks of endocrine disrupting chemicals
- Traffic and Road Safety
- Posttraumatic Stress Disorder Research
- Disaster Response and Management
- Air Quality and Health Impacts
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Body Composition Measurement Techniques
- Orthopaedic implants and arthroplasty
- Radiation Shielding Materials Analysis
- Trauma and Emergency Care Studies
- Toxic Organic Pollutants Impact
- Forensic Anthropology and Bioarchaeology Studies
Icahn School of Medicine at Mount Sinai
2016-2025
Stanford University
2025
Mayo Clinic Hospital
2024
Texas Christian University
2022-2024
South African Medical Research Council
1998-2021
Middle Tennessee State University
2020
Mount Sinai Hospital
2001-2019
Mount Sinai Hospital
2018
Parsons (United States)
2004-2013
New York State Department of Health
2005-2013
BackgroundApproximately 40,000 rescue and recovery workers were exposed to caustic dust toxic pollutants following the 11 September 2001 attacks on World Trade Center (WTC). These included traditional first responders, such as firefighters police, a diverse population of construction, utility, public sector workers.MethodsTo characterize WTC-related health effects, WTC Worker Volunteer Medical Screening Program was established. This multicenter clinical program provides free standardized...
<b><i>Objective:</i></b> To determine whether adults with past exposure to neurotoxicants have progressive declines in cognitive function years after has ceased, and tibia lead is a predictor of the magnitude change. <b><i>Methods:</i></b> A total 535 former organolead manufacturing workers mean age 55.6 years, duration 16 since last occupational exposure, low blood levels at first study visit 118 controls were evaluated neurobehavioral tests two four times over 4 years. “Peak” levels,...
<b>Objective: </b> To determine whether cumulative lead dose in former organolead workers was associated with MRI measures of white matter lesions (WML) and global structure-specific brain volumes. <b>Methods: MRIs, tibia lead, other were obtained from 532 a mean age 56 years 18 since last occupational exposure to lead. Cumulative measured by X-ray fluorescence, expressed as μg per gram bone mineral (μg Pb/g). WML evaluated using the Cardiovascular Health Study grading scale. A total 21...
<b>Objective: </b> To determine if long-term exposure to high levels of lead in the environment is associated with decrements cognitive ability older Americans. <b>Methods: We completed a cross-sectional analysis using multiple linear regression evaluate associations recent (in blood) and cumulative tibia) dose function 991 sociodemographically diverse, community-dwelling adults, aged 50 70 years, randomly selected from 65 contiguous neighborhoods Baltimore, MD. Tibia was measured...
Abstract In-vivo measurements of lead concentrations in calcaneus (mainly trabecular bone) and tibia cortical were performed by x-ray fluorescence (XRF) 70 active 30 retired smelter workers who had long-term exposure to lead. Comparison was made with 31 10 truck assembly no known occupational After physical examination, all participants provided blood urine samples answered a computerized questionnaire. Since 1950, has been determined repeatedly at the smelter, which it possible calculate...
Background. Several investigators have reported an association of blood lead or bone with increased pressure and hypertension, but questions remain concerning whether these effects are acute chronic in nature. Methods. In this longitudinal study, we evaluated the relation lead, measured tibia, to changes between 1994 1998. We studied 496 current former employees a chemical-manufacturing facility eastern United States who had previous occupational exposure inorganic organic lead. Cohort...
Few studies have compared associations of blood lead and tibia with pressure hypertension, differed in samples occupational exposure those mainly environmental exposure. African Americans been underrepresented prior studies. The authors performed a cross-sectional analysis 2001–2002 data from community-based cohort Baltimore, Maryland, 964 men women aged 50–70 years (40% American, 55% White, 5% other race/ethnicity) to evaluate systolic diastolic hypertension while adjusting for large set...
Our objective in this study was to determine if the known relation between tibia bone lead levels and neurobehavioral test scores are influenced by apolipoprotein E (ApoE) genotype. We collected data on 20 tests 529 former organolead workers who had an average of 16 years since last occupational exposure lead. used linear regression model relations each lead, a binary variable for ApoE genotype (i.e., at least one Epsilon4 allele vs. none), interaction term At time testing, were 57.6 age;...
A cross-sectional study was performed to evaluate the influence of polymorphisms in [delta]-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes on blood lead, tibia dimercaptosuccinic (DMSA)-chelatable lead levels 798 workers 135 controls without occupational exposure Republic Korea. Tibia assessed with a 30-min measurement by (109)Cd-induced K-shell X-ray fluorescence, DMSA-chelatable estimated as 4-hr urinary excretion after oral administration 10 mg/kg DMSA. The...
<b><i>Objective:</i></b> To evaluate the associations between tibial lead, dimercaptosuccinic acid (DMSA)-chelatable and neurobehavioral function in former organolead manufacturing workers with past exposure to organic inorganic lead. <b><i>Methods:</i></b> Data were collected from 543 subjects a mean age of 58 years an average 17.8 since last lead exposure. Years was used estimate levels year occupational exposure, termed "peak lead." Current levels, measured by x-ray fluorescence,...
Abstract The authors performed a cross-sectional study to evaluate associations between blood lead, tibia and dimercaptosuccinic acid (DMSA)-chelatable lead measures of neurobehavioral peripheral nervous system function among 803 lead-exposed workers 135 unexposed controls in South Korea. were enrolled the October 1997 August 1999. Central was assessed with modified version World Health Organization Neurobehavioral Core Test Battery. Peripheral by measuring pinch grip strength vibration...
No previous longitudinal studies have compared and contrasted associations of blood lead tibia with declines in cognitive function over the course time a large sample subjects current past occupational exposure to inorganic lead.From 1997 through 2001, we conducted study 803 former workers South Korea evaluate effects on central peripheral nervous systems. Three visits occurred during mean follow-up duration 2.20 years. Neurobehavioral test scores, system function, were measured at each 3...
Occupational exposure to lead may cause kidney damage. This study was carried out on a cohort of 70 active and 30 retired long term exposed smelter workers. Their function compared with 31 10 truck assembly workers who had no occupational lead. The been regularly followed up measurements concentration in blood since 1950. Previous calculated as time integrated index for each worker. Blood urine samples were obtained from all subjects. (B-Pb) (U-Pb) analysed. urinary concentrations several...
Before the 1970s, today's older Americans were exposed to high levels of lead in environment. The authors previously reported that lifetime cumulative dose was associated with lower cognitive test performance adults. Experiments suggest environmental stress may intensify detrimental influence lead. No large, population-based studies this question have been done. evaluated whether cross-sectional associations tibia function modified by neighborhood psychosocial hazards Baltimore Memory Study...
Background: The current population of older Americans has accumulated substantial lifetime lead doses, which raises concern about the possibility adverse cognitive outcomes. We evaluated whether cumulative dose from environmental exposures is associated with function and decline, such effects are persistent, reversible, or progressive. Methods: used longitudinal linear modeling to evaluate associations tibia concentration decline in sociodemographically diverse, community-dwelling adults...
Following the September 11, 2001, attacks on World Trade Center (WTC), thousands of workers were exposed to an array toxins known cause adverse health effects, including cancer. This study evaluates cancer incidence in WTC Health Program General Responder Cohort occurring within 12 years post exposure.The population consisted 28 729 members enrolled from cohort inception, July 2002 December 31, 2013. Standardized ratios (SIRs) calculated with case inclusion and follow-up starting 2001...