A5040602441- Computational Drug Discovery Methods
- Synthesis and biological activity
- Heat shock proteins research
- Virus-based gene therapy research
- Synthesis and Characterization of Heterocyclic Compounds
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Advanced Glycation End Products research
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Radiomics and Machine Learning in Medical Imaging
- Melanoma and MAPK Pathways
- RNA Research and Splicing
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Graphene and Nanomaterials Applications
- Cancer-related Molecular Pathways
- Tannin, Tannase and Anticancer Activities
- Mesenchymal stem cell research
- Glycosylation and Glycoproteins Research
- Lung Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Synthesis of Tetrazole Derivatives
- Microbial Natural Products and Biosynthesis
Istanbul Bilim University
2024
Istanbul University
2015-2023
University of Health Sciences Antigua
2023
Sağlık Bilimleri Üniversitesi
2020-2023
Abstract Background Carbazole-based molecules containing thiosemicarbazide functional groups are recognized for their diverse biological activities, particularly in enhancing therapeutic anticancer effects through inhibiting crucial pathways. These derivatives also exhibit noteworthy antioxidant properties. Objectives This study aims to synthesize, characterize, and evaluate the activities of 18 novel carbazole derivatives. Methods The radical scavenging capabilities compounds were assessed...
Intensive studies on hepatocellular carcinoma (HCC), which is spreading rapidly around the world and has a high mortality rate, due to lack of adequate preventive or curative treatment methods. Treating patients with HCC become very challenging because heterogeneity in patient population lead activation different signaling pathways, pathway crosstalk for patients. Therefore, understanding these molecular mechanisms combining drugs therapies overcome drawbacks an area utmost importance. In...
Background/Objectives: Gundelia tournefortii (Kenger) is a traditional medicinal plant and exhibits potential anticancer properties. This study investigates the cytotoxic apoptotic effects of its water extract on human lung carcinoma A549 cells. Methods: A cancer cell line was treated with extract. The metabolic content that plays key roles in detected by high-performance liquid chromatography. Anticancer properties were further flow cytometer apoptosis assay, signaling pathways determined...
Background: Mesenchymal stem cells (MSCs) have gained remarkable attention because of their ability to dualistically regulate tumor growth. The main objective this study was evaluate the apoptotic effects human bone marrow-derived (hBM) MSCs in combination with interferon gamma (IFN-γ) on MCF-7 breast cancer cells, and determine cytokines involved process. Materials Methods: hBM-MSCs were co-cultured either directly indirectly for 72 h in-vitro. Levels necrosis factor-related...
Parkinson's Disease (PD) is a neurodegenerative disorder distinguished from other disorders by the loss of dopaminergic neurons in substantia nigra region brain, and most common disorder, along with Alzheimer's Disease. PD characterized presence Lewy bodies when evaluated pathologically. Recent studies showed that incidence PH development as result genetic mutations alone very low among all cases, environmental effects contribute significantly to disease progression. The molecular mechanisms...
The Wnt pathway alterations have been identified in colorectal and many other cancer types. It has reported that galectin-3 (which is encoded by the LGALS3 gene) alters signaling mechanism Wnt/ β-catenin binding to colon cancers. AXIN1 mainly responsible for assembly of destruction complex pathway. This study investigated relationship rs4644 rs4652 variants gene rs214250 histopathological clinical properties. Our included a total 236 patients, whom 119 had (42 women, 77 men) 117 were healthy...
Abstract The extracellular signal‐regulated kinase (ERK) ‐ mitogen‐activated protein (MAPK) pathway regulates cell proliferation, differentiation, and apoptosis. Heat Shock Protein 90 (HSP90) is required to activate proto‐oncogenic kinases promotes tumor growth through anti‐apoptotic effects on A549‐non‐small lung cancer (NSCLC). Therefore, deregulation of the ERK‐MAPK abnormal expression HSP90 are reasonably frequent events in NSCLC. In this study, novel perimidine‐pyrazole compounds...
Cancer cells restrain apoptotic and senescence pathways through intracellular heat shock protein 70 (Hsp 70). These aid stimulus-independent growth, their higher metabolism rate requires Hsps. Hsps compensate abnormally increased substrate folding of cancer cells.Misfolding proteins especially signaling proteins, may not function properly. Therefore, Hsp70 folds these into native-fully functional states, this mode action helps cell survival.Targeting is promising therapy, in study,...
Abstract Katanin is a microtubule severing protein belonging to the ATPase family and consists of two subunits; p60‐katanin synthesized by KATNA1 gene p80‐katanin KATNB1 gene. Microtubule one mechanisms that allow reorganization microtubules depending on cellular needs. While this associated with mitosis in dividing cells, it primarily takes part formation structures such as axons dendrites nondividing mature neurons. Therefore, extremely important neuronal branching. p60 p80 katanin...