A5008942119- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Synthesis and Catalysis
- Synthesis of heterocyclic compounds
- Synthetic Organic Chemistry Methods
- Crystal structures of chemical compounds
- Vitamin C and Antioxidants Research
- Computational Drug Discovery Methods
- Organic Chemistry Cycloaddition Reactions
- Quinazolinone synthesis and applications
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Biological Evaluation
- Estrogen and related hormone effects
- Chemical Synthesis and Analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Free Radicals and Antioxidants
- Oxidative Organic Chemistry Reactions
- Bioactive Compounds and Antitumor Agents
- Multicomponent Synthesis of Heterocycles
- Enzyme Catalysis and Immobilization
- Synthesis and Reactivity of Heterocycles
- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
Fırat University
2008-2024
Politecnico di Milano
1991
Abstract Background Carbazole-based molecules containing thiosemicarbazide functional groups are recognized for their diverse biological activities, particularly in enhancing therapeutic anticancer effects through inhibiting crucial pathways. These derivatives also exhibit noteworthy antioxidant properties. Objectives This study aims to synthesize, characterize, and evaluate the activities of 18 novel carbazole derivatives. Methods The radical scavenging capabilities compounds were assessed...
Abstract In this research, the new hydrazine‐1‐carbothioamides (IC32 and IC34) having unsubstituted benzimidazole skeleton were converted to 1, 2, 4‐triazole derivatives (IC42 IC44) by N ‐cyclization reaction using microwave‐assisted synthesis method in basic medium with high efficiency a short time. 2‐Amino‐1,3,4‐thiadiazole (IC52 IC54) obtained from carbothioamides acidic S conventional method. The structure of all compounds was confirmed FT‐IR, 1 H NMR, 13 C NMR spectroscopic techniques....
The reaction of 2-hydroxy-1-naphthaldehyde with 1,3-dichloroacetone and potassium carbonate was used to prepare dinaphtho[2,1-b]furan-2-yl-methanone (1) as starting reagents. In order obtain dinaphtho[2,1-b]furan-2-yl-methanole (2), compound 1 reduced NaBH_4. N-oxime derivative this (3) synthesized by the hydroxylamine. Alkyl acyl substituted ethers (4-11) were obtained 3 various halogen containing compounds. Compound 12 reflux 11 hydrazine monohydrate in ethanol. 13 NaOH. compounds tested...
Abstract An efficient synthesis of 2‐arylamino‐2‐imidazolines from dimethyl N ‐aryldithioimidocarbonates and ethylenediamine on solid support under microwave irradiation has been developed. The reaction time reduced hours to minutes with improved yields as compared conventional heating. Their piperidin‐4‐ylmethyl morpholin‐4‐ylmethyl derivatives were synthesized by treatment formaldehyde piperidine or morpholine. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:142–222, 2005; Published...
Polyhydroxy steroids bearing the 3β,5α,6β‐trihydroxy pattern were synthesized from different heterocyclic‐substituted unsaturated steroid by an easy and simple method with high yields. The endocyclic double bond of thiophene‐substituted quinoline‐substituted converted to trans ‐diaxial diol regioselective stereoselective reactions m ‐chloroperoxybenzoic acid in basic medium.
When attempting to synthesize the symmetric aza-heterocyclic-substituted dibenzobarrelene derivatives from 2-aminobenzimidazole (or 2-aminoimidazoline) with diacid chlorides and diester in presence of various organic bases, different products were isolated high yield. NMR spectroscopic analysis proved these be dibenzobarrelene-substituted fused benzimidazodiazepine, imidazolinediazepine, dicarboxamides derivatives. Cyclic or noncyclic skeleton have been synthesized for first time using methods.
ABSTRACT A general and highly convenient procedure for the synthesis of 3-heteroaryl 3-aryl substituted-1H-indazoles has been developed. These compounds (3a–f) were synthesized in good yield by refluxing NaHSO3 adduct heteroaromatic aromatic aldehyde phenyl hydrazine DMF. This is more shorter than earlier methods. Five new 3-hetero-aryl characterized. New Mannich derivatives 3-(1H-pyrrol-2-yl)-1H-indazole (3a) 3-(1H-indol-3-yl)-1H-indazole (3b) prepared from morpholine formaldehyde.
Abstract Two different anhydrides having norbornene and dibenzobarrelene skeletons were synthesized from Diels‐Alder cycloaddition reactions using dienes such as anthracene cyclopentadiene, dienophiles like maleic acid anhydride. New benzimidazole derivatives bearing carboxamide, guanidine, cyclic imide functional groups obtained these anhydrides. The compounds investigated for their effects on MDA‐MB‐231 (Human breast cancer), A549 (Lung Ovcar3 Ovarian Panc1 (human pancreas cancer) cell...
The present study examined the influence of synthetic N-(1,3-benzothiazol-2-yl)-N-(4,5-dihydro-1H-imidazol-2-yl) amine (2-Amdz) on levels vitamins A, E and C malondialdehyde (MDA) in rats. A total 30 rats, divided into two groups, were used study. control group was given only a subcutaneous injection 250 ?L 75% ethanol, every other day. rats administered 2-Amdz (25 mg kg-1, dissolved ethanol). Injections continued for 16 days. After application days, serum determined by HPLC. vitamin E,...
As part of structural studies 1,2,4-triazole derivatives, the crystal structure title compound, C15H13N3S, has been investigated. The shows a V-shape in molecular skeleton, as found for similar compounds. is stabilized by an N—H⋯S and three C—H⋯π intermolecular interactions.
Abstract N-(1H-Imidazoline-2-yl)-1H-benzimidazol-2-amine hydroiodide was synthesized with excellent yields, and it converted to free base by using triethylamine under microwave irradiation (MWI) conditions. Its new Mannich, benzyl, allyl derivatives were synthesized.
Abstract 2-Aminoimidazolines were synthesized by the nucleophilic substitution reaction of 2-methylmercapto-4,5-dihydroimidazole hydroiodide with various amine compounds under neat conditions. Keywords: 2-Aminoimidazolinesmicrowave irradiationneat ACKNOWLEDGMENTS We are indebted to Scientific and Technological Research Council Turkey (TUBITAK, Project Number 105T419) for financial support this work. Notes a Yields refer isolated pure products. b MWI synthesis method. c Cited Ref. 19. d...
Abstract Substituted iminoimidazolines were synthesized from a one‐pot reaction of aromatic or hetero‐aromatic amines with imidazolidine‐2‐thione under solvent‐free conditions using microwave irradiation good to excellent yields.
In the title compound, C(13)H(9)N(3)S(2), thio-phene and phenyl rings are oriented at dihedral angles of 8.00 (7) 6.31 (7)°, respectively, with respect to central thia-diazole ring. No significant C-H⋯S π-π inter-actions exist in crystal structure.
Novel aza-heterocyclic substituted dehydroepiandrosterone derivatives were synthesized through a three-step reaction sequence. Some new O-alkylated 4-hydroxybenzaldehydes from the of benzaldehydes with dihalogen compounds which have different chain lengths. 16-Arylidene steroids base-catalyzed aldol condensation and dehydroepiandrosterone. New indolyl benzimidazolyl steroid as hybrid molecules obtained 16-arylidene indole or benzimidazole.