A5059739822- Synthesis and Catalytic Reactions
- MicroRNA in disease regulation
- Immune cells in cancer
- Chemical Synthesis and Analysis
- Catalytic Processes in Materials Science
- RNA modifications and cancer
- Catalysts for Methane Reforming
- Autophagy in Disease and Therapy
- Catalysis and Oxidation Reactions
- Oral and Maxillofacial Pathology
- Asymmetric Synthesis and Catalysis
- Cancer-related molecular mechanisms research
- Temporomandibular Joint Disorders
- Oxidative Organic Chemistry Reactions
- Ubiquitin and proteasome pathways
- Bone health and treatments
- Erythrocyte Function and Pathophysiology
- Facial Nerve Paralysis Treatment and Research
- Salivary Gland Tumors Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Synthesis and Reactions of Organic Compounds
- Dental Radiography and Imaging
- Orthodontics and Dentofacial Orthopedics
- Phagocytosis and Immune Regulation
- Click Chemistry and Applications
Nanjing Medical University
2015-2025
Jiangsu Province Hospital
2025
Stomatology Hospital
2021
Taiyuan University of Technology
2016-2019
Sichuan University
2014-2018
Shenyang Pharmaceutical University
2006-2008
China University of Petroleum, Beijing
2007
Rationale: Diabetes exacerbates the prevalence and severity of periodontitis, leading to severe periodontal destruction ultimately tooth loss. Delayed resolution inflammation is a major contributor diabetic periodontitis (DP) pathogenesis, but underlying mechanisms this imbalanced immune homeostasis remain unclear. Methods: We collected periodontium from with or without diabetes confirm dysfunctional neutrophils macrophages in aggravated inflammatory damage impaired resolution. Our vitro...
A highly enantioselective 1,3-dipolar cycloaddition of nitrile oxides with 3-arylidene-oxindoles was realized by a chiral N,N'-dioxide-nickel(II) complex catalyst under mild reaction conditions. series spiro-isoxazoline-oxindole derivatives were obtained in moderate yields (up to 65%) good regioselectivities 99:1), excellent enantioselectivities 99% ee), and exclusive diastereoselectivity as well.
We report the development of a chiral guanidine-based copper(I) catalyst for asymmetric azide-alkyne cycloaddition/[2+2] cascade reaction. Optically active spiroazetidinimine oxindoles were constructed by trapping ketenimine species under mild reaction conditions. High level enantioinduction and excellent isolated yields achieved in three-component various isatin-derived ketimines, sulfonyl azides, terminal alkynes. Control experiments X-ray crystallography used to probe into interaction...
Abstract Plp1-lineage Schwann cells (SCs) of peripheral nerve play a critical role in vascular remodeling and osteogenic differentiation during the early stage bone healing, abnormal plasticity SCs would jeopardize regeneration. However, how respond to injury initiate vascularized osteogenesis remains incompletely understood. Here, by employing single-cell transcriptional profiling combined with lineage-specific tracing models, we uncover that undergoing injury-induced glia-to-MSCs...
The present study was aimed to comprehensively evaluate changes in the masseter muscle patients with Class III facial asymmetry after bimaxillary orthognathic surgery and explore potential correlations between morphology or postoperative mandibular stability. Fifty-two eligible who underwent Le Fort I osteotomy bilateral sagittal split (BSSO) without genioplasty January 2019 June 2023 were included. Cone-beam computed tomography (CBCT) collected for each patient at 3 stages: 1 week...
Abstract Dysregulated abundance, location and transcriptional output of Hippo signaling effector TAZ have been increasingly linked to human cancers including head neck squamous cell carcinoma (HNSCC). is subjected ubiquitination degradation mediated by E3 ligase β-TRCP. However, the deubiquitinating enzymes mechanisms responsible for its protein stability remain underexplored. Here, we exploited customized deubiquitinases siRNA cDNA library screen strategies identified USP7 as a bona fide...
Abstract A highly efficient N , ′‐dioxide–Ni II catalyst system for the catalytic [3+2] cycloaddition of indoles with epoxides through CC cleavage oxiranes was accomplished under mild conditions. It provided a promising approach chiral furo[3,4‐ b ]indoles in up to 98 % yield 91 enantiomeric excess ( ee ) and >95:5 diastereomeric ratio (d.r.).
The highly efficient enantioselective [4 + 2] cycloaddition of o-QMs with ortho-hydroxyphenyl-substituted α,β-unsaturated compounds was realized by using a chiral N, N'-dioxide-Sc(III) complex as catalyst. A variety chromane derivatives three continuous stereocenters were obtained in excellent results (up to 99% yield, >19:1 dr, and ee) under low 0.005-1 mol % catalyst loading. Besides, catalytic cycle possible transition state model proposed elucidate the origin chirality.
Macrophage efferocytosis of apoptotic osteoblasts (apoOBs) is a key osteoimmune process for bone homeostasis. However, apoOBs frequently accumulate in aged marrow, where they may mount proinflammatory responses and progressive loss. The reason why are not cleared during aging remains unclear. In this study, it demonstrated that upregulate the immune checkpoint molecule CD47, which controlled by SIRT6-regulated transcriptional pausing, to evade clearance macrophages. Using osteoblast-...
An efficient enantioselective formal [3 + 2]-cycloaddition of azomethine imines with azlactones has been realized by using a chiral bifunctional bisguanidinium hemisalt as the catalyst. Optically active bicyclic pyrazolidinone compounds were generated under mild reaction conditions in high yields (up to 99%) good dr 88:12) and excellent ee values 99%). This simple strategy provides method construct biologically important tetrahydropyrazolo[1,2-a]pyrazole-1,7-dione derivatives bearing vicinal...
The development of a new bisguanidinium salt as multifunctional organocatalyst for asymmetric cascade esterification/aza-Michael reaction between 2-hydroxyphenyl-substituted enones and isocyanates is reported. A high level enantioinduction excellent isolated yields were achieved under mild conditions. Enantiomerically enriched 1,3-benzoxazin-2-ones constructed, possible catalytic model was suggested based on the mechanism-driven experiments.
In various kinds of carcinomas, the special AT-rich sequence-binding protein 2 (SATB2) with its atypical expression promotes metastasis and progression tumor, though in oral squamous cell carcinoma (OSCC) inherent mechanism status SATB2 remain unclear. The role played by OSCC lines tissue samples target miR-34a downstream is intended endeavor this study. te OSCCs was determined quantitative real-time polymerase chain reaction (q-PCR), while analyzed q-PCR western blot. Studies both vitro...
Autophagy-related genes (ARGs) have been significantly implicated in tumorigenesis and served as promising prognostic biomarkers for human cancer. Hence, this study was aimed to develop an ARGs-based signature Head neck squamous cell carcinoma (HNSCC).Prognostic ARG candidates were identified by univariate multivariate Cox regression analysis the training dataset (TCGA-HNSC) incorporated into a 3-ARGs (EGFR, FADD, PARK2) which further verified two independent validation cohorts (GSE41613...
This study aimed to comprehensively and quantitatively characterize 3-dimensional (3D) positional morphological changes of the condyle glenoid fossa in patients with skeletal Class II malocclusion treated bimaxillary orthognathic surgery. Twenty eligible at our institution from January 2016 December 2021 more than 12 months postoperative follow-up were retrospectively enrolled. Radiographic data cone-beam computed tomography (CBCT) for each patient collected 3 stages: 1 week preoperatively...
Age-related dysfunction of salivary glands (SGs) leading to xerostomia or dry mouth is typically associated with increased dental caries and difficulties in mastication, deglutition speech. Inflammaging-induced hyposalivation plays a significant role aged SGs; however, the mechanisms by which ageing shapes inflammatory microenvironment SGs remain unclear. Here, we show that reduced secretion flow rate human mice impaired autophagy M1 polarization macrophages. Our study reveals crucial roles...