A5100367476- Asymmetric Hydrogenation and Catalysis
- Catalytic C–H Functionalization Methods
- Synthetic Organic Chemistry Methods
- Synthesis and Catalytic Reactions
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Synthesis and biological activity
- Cyclopropane Reaction Mechanisms
- Zeolite Catalysis and Synthesis
- Catalysis and Oxidation Reactions
- Oxidative Organic Chemistry Reactions
- Carbon dioxide utilization in catalysis
- Synthesis and Biological Evaluation
- Microbial Natural Products and Biosynthesis
- Catalytic Processes in Materials Science
- Chemical Synthesis and Reactions
- Catalytic Alkyne Reactions
- Organometallic Complex Synthesis and Catalysis
- Chemical Synthesis and Characterization
- Natural product bioactivities and synthesis
- Biochemical and Molecular Research
- Catalysis and Hydrodesulfurization Studies
- Free Radicals and Antioxidants
- Chemical synthesis and alkaloids
Institute of Process Engineering
2018-2025
University of Chinese Academy of Sciences
2018-2025
Sichuan University
2011-2025
Yichun University
2024
Henan Normal University
2024
Beijing Institute of Fashion Technology
2024
Anhui Agricultural University
2024
Revolution Medicines (United States)
2022
Henan Provincial Eye Hospital
2022
Henan Provincial People's Hospital
2022
The one-step synthesis of methyl acrylate (MA) via the aldol condensation acetate (Ma) and formaldehyde (FA) has garnered considerable attention recently. Nevertheless, expensive Cs-based catalysts dominate this field, challenges exist with alternative alkali metal-based catalysts. Herein, K/Beta catalyst was tailored for catalytic transformation into acrylate. A series bifunctional varied acid–base characteristics were prepared through introduction metal K on acidic Beta zeolite support....
Sc takes action: The highly enantioselective hydroxyamination reaction of N-unprotected 2-oxindoles with nitrosoarenes has been realized using the Sc(OTf)3/L1 complex. catalyst system exhibited remarkably broad substrate scope and high efficiency. This transformation is first example a chiral ScIII/enolate activating nitrosoarene, can be conducted on gram scale without loss in ee values. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents...
Harzianone (2), a new harziane diterpene, was isolated from an alga-endophytic isolate of Trichoderma longibrachiatum. The structure and absolute configuration 2 were unambiguously identified by NMR mass spectrometric methods as well quantum chemical calculations. harziandione (1) supported calculation optical rotation, the isoharziandione revised to 1 on basis 13C data comparison calculation.
A highly enantioselective 1,3-dipolar cycloaddition of nitrile oxides with 3-arylidene-oxindoles was realized by a chiral N,N'-dioxide-nickel(II) complex catalyst under mild reaction conditions. series spiro-isoxazoline-oxindole derivatives were obtained in moderate yields (up to 65%) good regioselectivities 99:1), excellent enantioselectivities 99% ee), and exclusive diastereoselectivity as well.
Hyperactivation of mTOR kinase by mutations in the PI3K/mTOR pathway or crosstalk with other mutant cancer drivers, such as RAS, is a feature many tumors. Multiple allosteric inhibitors mTORC1 and orthosteric dual mTORC2 have been developed anticancer drugs, but their clinical utility has limited. To address these limitations, we novel class "bi-steric inhibitors" that interact both binding sites order to deepen inhibition while also preserving selectivity for over mTORC2. In this report,...
Abstract The iridium‐catalyzed, protecting group‐free synthesis of 4‐hydroxy‐2,6‐ cis ‐ or trans ‐pyrans through successive nucleophilic and electrophilic allylations chiral 1,3‐diols occurs with complete levels catalyst‐directed diastereoselectivity in the absence groups, premetallated reagents, discrete alcohol‐to‐aldehyde redox reactions.
Au/γ-AOOH shows outstanding activity for low-temperature oxidation of aromatic alcohols. Au/γ-Al 2 O 3 exhibits high CO.
The chiral cyclometalated π-allyliridium ortho-C,O-benzoate complex (R)-Ir-VIb derived from [Ir(cod)Cl]2, allyl acetate, 4-cyano-3-nitro-benzoic acid, and (R)-MeO-BIPHEP catalyzes the coupling of N-(p-nitrophenylsulfonyl) protected vinyl aziridine 3a with primary alcohols 1a–1l to furnish branched products C–C bond formation 4a–4l good levels anti-diastereo- enantioselectivity. In presence 2-propanol, but under otherwise identical conditions, aldehydes 2a–2l engage in reductive an equivalent...
Abstract Catalytic kinetic resolution of amines represents a longstanding challenge in chemical synthesis. Here, we described secondary through oxygenation to produce enantiopure hydroxylamines involving N–O bond formation. The economic and practical titanium-catalyzed asymmetric with environmentally benign hydrogen peroxide as oxidant is applicable range racemic indolines multiple stereocenters diverse substituent patterns high efficiency efficient chemoselectivity enantio-discrimination....
Supported Cs-based catalysts are considered as potential candidates for methyl methacrylate (MMA) synthesis via one-step aldol condensation, but they suffer from low activity. In this paper, the acid–base properties of Cs/SiO2 catalyst were modulated by loading different amounts Al element. The changes in structural and physicochemical following introduction revealed a series characterizations. In-depth investigation catalytic mechanism through situ DRIFT combined with DFT calculations...
The increased plasma free fatty acid levels due to the deregulated lipolysis in adipocytes are considered as one of major risk factors for developing type II diabetes. Vanadium compounds well-known their antidiabetic effects both on glucose and lipid metabolism, but mechanisms still not completely understood. present study suggests a mechanism how vanadium exert antilipolytic effects. It demonstrates that all three compounds, bis(acetylacetonato)-oxovanadium(iv) (VO(acac)2),...
Transfer hydrogenative coupling of styrene with primary alcohols using the precatalyst HClRu(CO)(PCy3 )2 modified by AgOTf or HBF4 delivers branched linear adducts from benzylic aliphatic alcohols, respectively. Related 2-propanol mediated reductive couplings also are described.
Cycloheptenones are widespread in natural products and bioactive molecules. An efficient convenient NaH-mediated Cope Rearrangement of doubly activated vinylcyclopropanes is reported for the synthesis cyclohepten-4-ones. These flexible intramolecular reactions were applicable to a wide range substrates could be performed on gram scale. The derivatization product leads short highly some useful functional
The polyketide natural product (+)-SCH 351448, a macrodiolide ionophore bearing 14 stereogenic centers, is prepared in steps (LLS). In eight prior syntheses, 22–32 were required. Multiple chemoselective and redox-economic functional group interconversions collectively contribute to step-change efficiency.
In this work, a series of novel benzyl naphthyl sulfoxides (sulfones) derived from Ex-RAD were designed and synthesized as potential radioprotective agents.
Abstract Transfer hydrogenative coupling of styrene with primary alcohols using the precatalyst HClRu(CO)(PCy 3 ) 2 modified by AgOTf or HBF 4 delivers branched linear adducts from benzylic aliphatic alcohols, respectively. Related 2‐propanol mediated reductive couplings also are described.
N-Galactosyl aziridines were synthesized via BF3·OEt2 promoted addition of carbenes generated from diazocarbonyl compounds with O-pivaloylated β-D-galactosylimines in good yields and high diastereoselectivity. The ring-opening reactions p-toluenethiol the provided enantiometrically pure β-S-substituted phenylalanine derivatives a highly regioselective manner.
In this work, a series of novel benzyl sulfoxide 2-indolinone derivatives was designed and synthesized as potent anticancer agents. Tyrosine kinase inhibitory activity assay indicated that most the compounds showed significant activity. The in vitro antiproliferative these further investigated against five human cancer cell lines (HeLa, HepG2, MCF-7, SCC-15, A549). Several exhibited evident activities. Among them, (Z)-3-(((4-bromobenzyl)sulfinyl)methylene)indolin-2-one (6j)...
Abstract Three new types of heterogeneous catalysts were prepared using a facile approach by the immobilization Grubbs on PEGylated Merrifield resin. One immobilized was more efficient than free catalyst for metathesis leaf alcohols in conversion and selectivity reused repeatedly (up to 5 cycles) with only slight loss activity (10.5 %). The long‐chain linker provided an appropriate distance between resin catalytic center so that ruthenium acted as catalyst.
1,2-Bis(diphenylphosphino)ethanes (DPPEs) are versatile and immensely important ligands in transition metal catalysts. Here we report the dithiophosphinylation of readily available allenyl acetates to give DPPEs high yields regioselectivity. This protocol features a broad substrate scope mild conditions, avoiding use metals air-sensitive sources phosphorus. Mechanism studies indicate that reaction was accomplished via an SN2′-type addition–elimination followed by 1,4-addition step.