A5057426929- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Photochromic and Fluorescence Chemistry
- Click Chemistry and Applications
- Land Use and Ecosystem Services
- Carbohydrate Chemistry and Synthesis
- Natural product bioactivities and synthesis
- Immune Response and Inflammation
- Effects of Radiation Exposure
- Soil erosion and sediment transport
- Genomics, phytochemicals, and oxidative stress
- Sleep and Wakefulness Research
- Synthesis and Biological Evaluation
- Metallic Glasses and Amorphous Alloys
- Obstructive Sleep Apnea Research
- DNA Repair Mechanisms
- Polydiacetylene-based materials and applications
- Synthetic Organic Chemistry Methods
- Bioactive Compounds and Antitumor Agents
- Liver physiology and pathology
- Free Radicals and Antioxidants
- Radical Photochemical Reactions
- Microbial Natural Products and Biosynthesis
- Circadian rhythm and melatonin
- Enzyme function and inhibition
Beijing Radiation Center
2015-2024
China University of Geosciences (Beijing)
2022-2024
Peking University
2023-2024
Academy of Military Medical Sciences
2017-2018
Beijing Proteome Research Center
2015
Northeastern University
1991-1995
Shenyang University of Technology
1988
Shenyang Institute of Engineering
1986
Toll-like receptor (TLR) 2 is a transmembrane that participates in the innate immune response by forming heterodimer with TLR1 or TLR6. TLR2 agonists play an important role tumor therapy. Herein, we synthesized series of 3-(2H-chromen-3-yl)-5-aryl-1,2,4-oxadiazole derivatives and identified WYJ-2 as potent small selective molecule agonist TLR2/1, EC50 18.57 ± 0.98 nM human transient-cotransfected HEK 293T cells. promoted formation TLR2/1 heterodimers activated nuclear factor kappa B (NF-κB)...
Human hepatocellular carcinoma (HCC) lacks effective curative therapy and there is an urgent need to develop a novel molecular-targeted for HCC. Selective tyrosine kinase inhibitors have shown promise in treating cancers including Tyrosine kinases c-Met Trks are potential therapeutic targets of HCC strategies interrupt cross-signaling may result increased effects on inhibition. The Indo5 activity were determined with vitro assay, cell-based signaling pathway activation, kinases-driven cell...
In this work, a series of benzylsulfone coumarin derivatives 5a-5o were synthesized and characterized. Kinase inhibitory activity assay indicated that most the compounds showed considerable against PI3K. Anti-tumor studies active also carried out in vitro on Hela, HepG2, H1299, HCT-116, MCF-7 tumor cell lines by MTS assay. The structure-activity relationships (SARs) these analyzed detail. Compound 5h exhibited potent activities mentioned with IC50 values ranging from 18.12 to 32.60 μM,...
Coumarin moiety has garnered momentous attention especially in the design of compounds with significant biological activities. In this work, a series 3-substituted coumarin derivatives 6a–6l were synthesized and fully characterized. Most could obviously inhibit activity cyclooxygenase-1 (COX-1) at concentration 10 µM. Besides, 6h 6l exhibited highest inhibitory effects against COX-2 inhibition rates 33.48 35.71%, respectively. Detailed structure–activity relationships (SARs) also discussed....
In this work, a series of novel benzyl naphthyl sulfoxides (sulfones) derived from Ex-RAD were designed and synthesized as potential radioprotective agents.
Nrf2 is the key transcription factor regulating antioxidant response which crucial for cytoprotection against extracellular stresses. Numerous in vivo studies indicate that plays a protective role anti-inflammatory response. 3-(3-Pyridylmethylidene)-2-indolinone (PMID) synthesized derivative of 2-indolinone compounds. Our previous study suggested PMID induces activation Nrf2/ARE pathway, then protecting oxidative stress-mediated cell death. However, little known regarding properties severe...
KFL displays a protective effect against HPM-induced cognitive impairment and histopathological changes by ameliorating oxidative stress <italic>via</italic> the Nrf2-ARE signaling pathway.
In this work, a series of novel benzyl sulfoxide 2-indolinone derivatives was designed and synthesized as potent anticancer agents. Tyrosine kinase inhibitory activity assay indicated that most the compounds showed significant activity. The in vitro antiproliferative these further investigated against five human cancer cell lines (HeLa, HepG2, MCF-7, SCC-15, A549). Several exhibited evident activities. Among them, (Z)-3-(((4-bromobenzyl)sulfinyl)methylene)indolin-2-one (6j)...
Abstract Three new types of heterogeneous catalysts were prepared using a facile approach by the immobilization Grubbs on PEGylated Merrifield resin. One immobilized was more efficient than free catalyst for metathesis leaf alcohols in conversion and selectivity reused repeatedly (up to 5 cycles) with only slight loss activity (10.5 %). The long‐chain linker provided an appropriate distance between resin catalytic center so that ruthenium acted as catalyst.
A series of benzofuran derivatives were designed and synthesized, their inhibitory activites measured against the SIRT1–3. The enzymatic assay showed that all compounds certain anti-SIRT2 activity selective over SIRT1 SIRT3 with IC50 (half maximal concentration) values at micromolar level. preliminary structure–activity relationships analyzed binding features compound 7e (IC50 3.81 µM) was predicted using CDOCKER program. results this research could provide informative guidance for further...