Astrocytes are the most abundant glial cell in retinal nerve fiber layer (NFL) and optic head (ONH), perform essential roles maintaining ganglion (RGC) detoxification homeostasis. Mature astrocytes relatively quiescent, but rapidly undergo a phenotypic switch response to insult, characterized by upregulation of intermediate filament proteins, loss glutamate buffering, secretion pro-inflammatory cytokines, increased antioxidant production. These changes result both positive negative...

Recently, ShiftViT and its variants have attracted much attention for their simple efficient shift operation, showing excellent efficacy in several tasks on natural images, surpassing Swin Transformer. However, considering the complexity of 3D multimodal which higher dimensions than relative stability human tissue structure medical applicability operation data has yet to be determined. This paper demonstrates that enormous potential image analysis. Using segmentation as a representative...

Abstract Reactive gliosis is an early pathological feature common to most neurodegenerative diseases, yet its regulation and impact remain poorly understood. Normally astrocytes maintain a critical homeostatic balance. After stress or injury they undergo rapid parainflammatory activation, characterized by hypertrophy, increased polymerization of type III intermediate filaments (IFs), particularly glial fibrillary acidic protein vimentin. However, the consequences IF dynamics in adult CNS...

Today, iris recognition, fingerprint face voice recognition and other biometric technology are experiencing rapid development. This paper addresses a new - skeleton for blood vessel of optic fundus. The green grayscale ocular fundus image is utilized. feature extracted at first. After filtering treatment extracting feature, vector curve vessels obtained. Shape matching later carried out by means reference point matching. has been demonstrated in this to possess high rate, low rejection rate...

Localization is a vital service in underwater acoustic sensor networks (UASNs). Autonomous vehicles (AUVs), with their mobility and collaborations can provide accurate, extensive, efficient localization for large-scale UASNs. During localization, AUVs travel along the predefined paths broadcast reference messages to aid nodes estimating locations. However, AUVs-aided faces following two challenges: 1) complex path planning multiple AUVs, which requires consideration of accuracy optimization...

Fourier-Mellin transform (FMT) is frequently used in content-based image retrieval and digital watermarking. This paper extends the application of FMT into registration proposes an improved algorithm based on for alignment images differing translation, rotation angle, uniform scale factor. The proposed can eliminate conversion from Cartesian to log-polar coordinates, avoid process interpolation required conversion, obtain a more signi?cant improvement than conventional method using...

Abstract Impaired endothelial repair is a key contributor to microvascular rarefaction and consequent end-organ dysfunction in diabetes. Recent studies suggest an important role for bone marrow-derived early outgrowth cells (EOCs) mediating repair, but the function of these impaired diabetes, as advanced age. We sought determine whether diabetes-associated EOC might be attenuated by pharmacological activation silent information regulator protein 1 (SIRT1), lysine deacetylase implicated...

Hard exudates are the main symptom of diabetic retinopathy. Early detection hard can help reduce risk blinding. However, exudate is a challenging task due to their various sizes and intensities, which cause misdetection. Aiming at problem low accuracy efficiency for most existing methods, we propose an Enhanced Multi-feature Fusion Network (EMFN) lessen burden ophthalmologists detect more accurately efficiently. Our network belongs category Convolutional Neural (CNN), adopts fuses multiple...

Automatic fovea localization is a challenging issue. In this article, we focus on the study of and propose robust method. We concentric circular sectional symmetry measure (CCSSM) for axis detection, region interest (ROI) determination, which global feature descriptor against local changes, to solve lesion interference issue, i.e., visibility from lesions, using both structure features morphological features. index convexity concavity (ICC) as convexity-concavity surface provide quantitative...

Abstract Glaucoma is a common neurodegenerative blinding disease that closely associated with chronic biomechanical strain at the optic nerve head (ONH). Yet, cellular injury and mechanosensing mechanisms underlying resulting damage have remained critically unclear. We previously identified Annexin A4 (ANXA4) from proteomic analyses of human ONH astrocytes undergoing pathological mimics glaucomatous conditions. Annexins are family calcium‐dependent phospholipid binding proteins key functions...

Recently traditional Chinese medicine (TCM)-induced liver injury has been an unresolved critical issue which impacts TCM clinical safety. The premise and key step to reduce or avoid drug-induced (DILI) is identify the drug source of in early stage. Then timely withdrawal treatment can be done. However, current diagnosis DILI primarily governed by exclusive method relying on administering history supplied patients experience judgment from doctors, lacks objective reliable diagnostic indices....

Localization is vital and fundamental for underwater acoustic sensor networks (UASNs), as it provides location information UASNs to achieve various practical tasks. Most existing localization methods assume small-scale scenarios without battery energy constraints, making inapplicable large-scale UASNs. In UASNs, suffers from the challenges of excessive consumption large error because harsh conditions like node mobility huge ranging errors. To this end, we propose an efficient scheme with...